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Pre-injury Treatment of Methylprednisolone in Experimental Spinal Cord Injury

Yoon DH, Kim YS, Young W

  • KMID: 2018900
  • J Korean Neurosurg Soc.
  • 1996 Aug;25(8):1568-1576.
The purpose of this study was to establish whether pre-injury administration of the methylprednisolone sodium succinate(MP) is effective for the treatment of acute spinal cord injury in rat, as it...
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Therapeutic time window for methylprednisolone in spinal cord injured rat

Yoon DH, Kim YS, Young W

Recent clinical trials have reported that methylprednisolone sodium succinate administered within 8 hours improves neurological recovery in human spinal cord injury (SCI). Methylprednisolone, however, was ineffective and possibly...
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Serotonin 1A Receptor Agonist(8 OH DPAT) Reduces Tissue Lesion Volume in the Rat Middle Cerebral Artery Occlusion Model of Ischemia

Yoon DH, Kim YS, Young W

  • KMID: 2067415
  • J Korean Neurosurg Soc.
  • 1996 Jul;25(7):1352-1363.
We studied the effectiveness of serotonin 1a agonist(8 OH DPAT) on the 24 hour ionic lesion volume produced by permanent occlusion of the middle cerebral artery(MCAo) in rats. A 4-hour...
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Glutamine Synthetase Induced Spinal Seizures in Rats

Shin DW, Yoon YS, Matsumoto , Huang W, Ceraulo P, Young W

Glutamine synthetase (GS) is a key enzyme in the regulation of glutamate neurotransmission in the central nervous system. It is responsible for converting glutamate to glutamine, consuming one ATP and...
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