- Altered GABAergic Signaling in Brain Disease at Various Stages of Life
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Kim YS, Yoon BE
- KMID: 2383781
- Exp Neurobiol.
- 2017 Jun;26(3):122-131.
- doi: 10.5607/en.2017.26.3.122
In the healthy brain, gamma-aminobutyric acid (GABA) is regulated by neurons and glia. This begs the question: what happens in the malfunctioning brain? There are many reasons why diseases occur,... -
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- Generation of Astrocyte-Specific MAOB Conditional Knockout Mouse with Minimal Tonic GABA Inhibition
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Lee JM, Sa M, An H, Kim JMJ, Kwon J, Yoon BE, Lee CJ
- KMID: 2531119
- Exp Neurobiol.
- 2022 Jun;31(3):158-172.
- doi: 10.5607/en22016
Monoamine oxidase B (MAOB) is a key enzyme for GABA production in astrocytes in several brain regions. To date, the role of astrocytic MAOB has been studied in MAOB null... -
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- Decreased Glial GABA and Tonic Inhibition in Cerebellum of Mouse Model for Attention-Deficit/Hyperactivity Disorder (ADHD)
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Kim YS, Woo J, Lee CJ, Yoon BE
- KMID: 2389007
- Exp Neurobiol.
- 2017 Aug;26(4):206-212.
- doi: 10.5607/en.2017.26.4.206
About 5~12% of school-aged children suffer from the Attention-Deficit/Hyperactivity Disorder (ADHD). However, the core mechanism of ADHD remains unclear. G protein-coupled receptor kinase-interacting protein-1 (GIT1) has recently been reported to... -
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- Unaltered Tonic Inhibition in the Arcuate Nucleus of Diet-induced Obese Mice
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Sa M, Lee JM, Park MG, Lim J, Joseph Kim JM, Koh W, Yoon BE, Lee CJ
- KMID: 2531118
- Exp Neurobiol.
- 2022 Jun;31(3):147-157.
- doi: 10.5607/en22014
The principal inhibitory transmitter, γ-aminobutyric acid (GABA), is critical for maintaining hypothalamic homeostasis and released from neurons phasically, as well as from astrocytes tonically. Although astrocytes in the arcuate nucleus... -
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- Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRAC(swell)) in the Brain
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Han YE, Kwon J, Won J, An H, Jang MW, Woo J, Lee JS, Park MG, Yoon BE, Lee SE, Hwang EM, Jung JY, Park H, Oh SJ, Lee CJ
- KMID: 2450213
- Exp Neurobiol.
- 2019 Apr;28(2):183-215.
- doi: 10.5607/en.2019.28.2.183
In the brain, a reduction in extracellular osmolality causes water-influx and swelling, which subsequently triggers Clâ»- and osmolytes-efflux via volume-regulated anion channel (VRAC). Although LRRC8 family has been recently proposed... -
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