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Sex-dependent liver cancer xenograft models for predicting clinical data in the evaluation of anticancer drugs

Oh S, Jung J

Background The incidence and mortality of liver cancer show a great difference between the sexes. We established sex-dependent liver cancer xenograft models and investigated whether such sex-dependent models could be used...
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Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xenograft samples

Barwe SP, Gopalakrisnapillai A, Mahajan N, Druley TE, Kolb EA, Crowgey EL

Acute leukemia represents the most common pediatric malignancy comprising diverse subtypes with varying prognosis and treatment outcomes. New and targeted treatment options are warranted for this disease. Patient-derived xenograft (PDX)...
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Patient-Derived Xenograft Models of Epithelial Ovarian Cancer for Preclinical Studies

Heo EJ, Cho YJ, Cho WC, Hong JE, Jeon HK, Oh DY, Choi YL, Song SY, Choi JJ, Bae DS, Lee YY, Choi CH, Kim TJ, Park WY, Kim BG, Lee JW

PURPOSE: Patient-derived tumor xenografts (PDXs) can provide more reliable information about tumor biology than cell line models. We developed PDXs for epithelial ovarian cancer (EOC) that have histopathologic and genetic...
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Establishing a colorectal cancer liver metastasis patient-derived tumor xenograft model for the evaluation of personalized chemotherapy

Jung J, Kim J, Lim HK, Kim KM, Lee YS, Park JS, Yoon DS

PURPOSE: In order to suggest optimal anticancer drugs for patient-tailored chemotherapy, we developed a colorectal cancer (CRC)-liver metastasis patient-derived tumor xenograft (PDTX) model. METHODS: Tissue obtained from a patient with CRC-liver...
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Retrospective growth kinetics and radiosensitivity analysis of various human xenograft models

Lee JY, Kim MS, Kim EH, Chung N, Jeong YK

The purpose of this study was to delineate the various factors that affect the growth characteristics of human cancer xenografts in nude mice and to reveal the relationship between the...
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Tumor Growth Suppression and Enhanced Radioresponse by an Exogenous Epidermal Growth Factor in Mouse Xenograft Models with A431 Cells

Lim YJ, Jeon SR, Koh JM, Wu HG

PURPOSE: The purpose of this study was to evaluate whether an exogenous epidermal growth factor (EGF) could induce anti-tumor and radiosensitizing effects in vivo. MATERIALS AND METHODS: BALB/c-nu mice that were...
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Preclinical Efficacy Testing for Stomach and Liver Cancers

Park JW, Baek NS, Lee SC, Oh SJ, Jang SH, Kim IH, Kim DY, Kim HK

  • KMID: 2167682
  • Cancer Res Treat.
  • 2014 Apr;46(2):186-193.
PURPOSE: Hollow fiber assays offer an early in vivo method of anticancer drug screening. The assays have been optimized for human cancers originating from the lung, breast, colon, ovary, and...
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Xenografted Tumorigenesis in the oral vestibule of nude mice by Snail transfection: Histological and immunohistochemical study

Kim MK, Lee EH, Kim J, Yook JI, Cha IH

  • KMID: 1474219
  • J Korean Assoc Oral Maxillofac Surg.
  • 2009 Aug;35(4):199-204.
PURPOSE: The purpose of this study is to investigate the epithelial-mesenchymal transition (EMT) induced by Snail transcription factor and Snailtransfected in vivo tumors with histopathological features. MATERIALS AND METHODS: We induced...
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Effect of Paclitaxel on PC-3 Cell Line Xenografted into Athymic Nude Mice

Kang SH, Cheon J, Yoon DK

  • KMID: 1764825
  • Korean J Urol.
  • 2004 Mar;45(3):263-267.
PURPOSE: Hormone-refractory prostate cancer(HRPC) is the terminal step in the natural history of prostate cancer, for which no chemotherapeutic agents have been shown to impact on the clinical outcomes. However,...
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