- Therapeutic effects of stiripentol against ischemia-reperfusion injury in gerbils focusing on cognitive deficit, neuronal death, astrocyte damage and blood brain barrier leakage in the hippocampus
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Shin MC, Lee TK, Lee JC, Kim HI, Park CW, Cho JH, Kim DW, Ahn JH, Won MH, Lee CH
- KMID: 2524530
- Korean J Physiol Pharmacol.
- 2022 Jan;26(1):47-57.
- doi: 10.4196/kjpp.2022.26.1.47
Stiripentol is an anti-epileptic drug for the treating of refractory status epilepticus. It has been reported that stiripentol can attenuate seizure severity and reduce seizure-induced neuronal damage in animal models... -
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- Hypothermic treatment reduces matrix metalloproteinase-9 expression and damage in the liver following asphyxial cardiac arrest in rats
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Kim D, Kim B, Sim H, Lee TK, Tae HJ, Lee JC, Park JH, Cho JH, Won MH, Park Y, Ahn JH
- KMID: 2521033
- Lab Anim Res.
- 2021 Sep;37(3):185-192.
- doi: 10.1186/s42826-021-00095-z
Background: Hypothermic treatment is known to protect organs against cardiac arrest (CA) and improves survival rate. However, few studies have evaluated the effects of hypothermia on CA-induced liver damages. This... -
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- Comparison of age‐dependent alterations in thioredoxin 2 and thioredoxin reductase 2 expressions in hippocampi between mice and rats
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Yoo YH, Kim DW, Chen BH, Sim H, Kim B, Lee JC, Ahn JH, Park Y, Cho JH, Kang IJ, Won MH, Lee TK
- KMID: 2514401
- Lab Anim Res.
- 2021 Mar;37(1):90-97.
- doi: joohee@duksung.ac.kr
Background Aging is one of major causes triggering neurophysiological changes in many brain substructures, including the hippocampus, which has a major role in learning and memory. Thioredoxin (Trx) is a class... -
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- Therapeutic hypothermia reduces inflammation and oxidative stress in the liver after asphyxial cardiac arrest in rats
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Park Y, Ahn JH, Lee TK, Kim B, Tae HJ, Park JH, Shin MC, Cho JH, Won MH
- KMID: 2510548
- Acute Crit Care.
- 2020 Nov;35(4):286-295.
- doi: 10.4266/acc.2020.00304
Background: Few studies have evaluated the effects of hypothermia on cardiac arrest (CA)-induced liver damage. This study aimed to investigate the effects of hypothermic therapy on the liver in a... -
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- High fat diet accelerates and exacerbates microgliosis and neuronal damage/death in the somatosensory cortex after transient forebrain ischemia in gerbils
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Seo WJ, Ahn JH, Lee TK, Kim B, Lee JC, Park JH, Yoo YH, Shin MC, Cho JH, Won MH, Park Y
- KMID: 2507236
- Lab Anim Res.
- 2020 Sep;36(3):229-238.
- doi: 10.1186/s42826-020-00061-1
Obesity has been known as an independent risk factor for stroke. Effects of high-fat diet (HFD)-induced obesity on neuronal damage in the somatosensory cortex of animal models of cerebral ischemia... -
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- Brain Factor-7® improves learning and memory deficits and attenuates ischemic brain damage by reduction of ROS generation in stroke in vivo and in vitro
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Noh Y, Lee JW, Hong J, Kim SS, Ahn JH, Lee TK, Kim B, Won MH
- KMID: 2507227
- Lab Anim Res.
- 2020 Sep;36(3):188-196.
- doi: 10.1186/s42826-020-00057-x
Brain Factor-7® (BF-7), silk fibroin peptide, is known to be effective in improvement of memory and learning ability. In this study, the effects of BF-7 (10 mg/kg, p.o., pre-treatment for 7 days... -
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- Mediating Effect of Physical Activity in the Relationship between Depressive Symptoms and Health-related Quality of Life in Patients with Coronary Artery Disease: The 2016 Nationwide Community Health Survey in Korea
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Won MH
- KMID: 2466234
- Korean J Adult Nurs.
- 2019 Dec;31(6):691-700.
- doi: 10.7475/kjan.2019.31.6.691
PURPOSE: This study aimed to examine the mediating role of physical activity in the relationship between depressive symptoms and health-related quality of life in patients with coronary artery disease. METHODS: A... -
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- Age-dependent changes of p53 and p63 immunoreactivities in the mouse hippocampus
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Lee TK, Park YE, Park CW, Kim B, Lee JC, Park JH, Lee HA, Won MH, Ahn JH
- KMID: 2470010
- Lab Anim Res.
- 2019 Oct;35(3):140-147.
- doi: 10.1186/s42826-019-0022-0
P53 and its family member p63 play important roles in cellular senescence and organismal aging. In this study, p53 and p63 immunoreactivity were examined in the hippocampus of young, adult... -
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- Arg-Leu-Tyr-Glu Suppresses Retinal Endothelial Permeability and Choroidal Neovascularization by Inhibiting the VEGF Receptor 2 Signaling Pathway
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Park W, Baek YY, Kim J, Jo DH, Choi S, Kim JH, Kim T, Kim S, Park M, Kim JY, Won MH, Ha KS, Kim JH, Kwon YG, Kim YM
- KMID: 2456222
- Biomol Ther.
- 2019 Sep;27(5):474-483.
- doi: 10.4062/biomolther.2019.041
Vascular endothelial growth factor (VEGF) plays a pivotal role in pathologic ocular neovascularization and vascular leakage via activation of VEGF receptor 2 (VEGFR2). This study was undertaken to evaluate the... -
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- RbAp48 expression and neuronal damage in the gerbil hippocampus following 5 min of transient ischemia
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Park JH, Lee TK, Kim DW, Park CW, Park YE, Kim B, Lee JC, Lee HA, Won MH, Ahn JH
- KMID: 2470111
- Lab Anim Res.
- 2019 Aug;35(2):78-85.
- doi: 10.1186/s42826-019-0011-3
Histone-binding protein RbAp48 has been known to be involved in histone acetylation, and epigenetic alterations of histone modifications are closely associated with the pathogenesis of ischemic reperfusion injury. In the... -
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- A Prediction Model for Physical Activity Adherence for Secondary Prevention among Patients with Coronary Artery Disease
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Won MH, Kim O
- KMID: 2438763
- Korean J Adult Nurs.
- 2019 Feb;31(1):78-88.
- doi: 10.7475/kjan.2019.31.1.78
PURPOSE: The purpose of this study was to construct and test a predictive model for physical activity adherence for secondary prevention among patients with coronary artery disease. METHODS: Two hundred and... -
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- Preliminary Study of the Antioxidant Effects of Oenanthe javanica Extract on the Skin of Aged Mice
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Her Y, Shin BN, Lee HS, Min JH, Won MH, Lee YL
- KMID: 2433652
- Korean J Dermatol.
- 2019 Jan;57(1):53-56.
No abstract available. -
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- The relationship between low survival and acute increase of tumor necrosis factor α expression in the lung in a rat model of asphyxial cardiac arrest
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Park Y, Tae HJ, Cho JH, Kim IS, Ohk TG, Park CW, Moon JB, Shin MC, Lee TK, Lee JC, Park JH, Ahn JH, Kang SH, Won MH, Cho JH
- KMID: 2421177
- Anat Cell Biol.
- 2018 Jun;51(2):128-135.
- doi: 10.5115/acb.2018.51.2.128
Cardiac arrest (CA) is sudden loss of heart function and abrupt stop in effective blood flow to the body. The patients who initially achieve return of spontaneous circulation (RoSC) after... -
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- Arginase Inhibition Suppresses Native Low-Density Lipoprotein-Stimulated Vascular Smooth Muscle Cell Proliferation by NADPH Oxidase Inactivation
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Koo BH, Yi BG, Wang WK, Ko IY, Hoe KL, Kwon YG, Won MH, Kim YM, Lim HK, Ryoo S
- KMID: 2407859
- Yonsei Med J.
- 2018 May;59(3):366-375.
- doi: 10.3349/ymj.2018.59.3.366
PURPOSE: Vascular smooth muscle cell (VSMC) proliferation induced by native low-density lipoprotein (nLDL) stimulation is dependent on superoxide production from activated NADPH oxidase. The present study aimed to investigate whether... -
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- Arginase II inhibition prevents interleukin-8 production through regulation of p38 MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs
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Koo BH, Yi BG, Jeong MS, Kwon SH, Hoe KL, Kwon YG, Won MH, Kim YM, Ryoo S
- KMID: 2440020
- Exp Mol Med.
- 2018 Feb;50(2):e438.
- doi: 10.1038/emm.2017.254
Arginase inhibition exhibits beneficial effects in vascular endothelial and smooth muscle cells. In human aortic smooth muscle cells (hAoSMCs), native low-density lipoprotein (nLDL) induced the production of interleukin-8 (IL-8) that... -
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- Pre-treated Populus tomentiglandulosa extract inhibits neuronal loss and alleviates gliosis in the gerbil hippocampal CA1 area induced by transient global cerebral ischemia
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Park JH, Lee TK, Ahn JH, Shin BN, Cho JH, Kim IH, Lee JC, Kim JD, Lee YJ, Kang IJ, Hong S, Kim YH, Jeon YH, Lee YL, Won MH
- KMID: 2399897
- Anat Cell Biol.
- 2017 Dec;50(4):284-292.
- doi: 10.5115/acb.2017.50.4.284
The genus Populus (poplar) belonging to the Salicaceae family has been used in traditional medicine, and its several species show various pharmacological properties including antioxidant and anti-inflammatory effects. No study... -
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- Carbon monoxide prevents TNF-α-induced eNOS downregulation by inhibiting NF-κB-responsive miR-155-5p biogenesis
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Choi S, Kim J, Kim JH, Lee DK, Park W, Park M, Kim S, Hwang JY, Won MH, Choi YK, Ryoo S, Ha KS, Kwon YG, Kim YM
- KMID: 2396808
- Exp Mol Med.
- 2017 Nov;49(11):e403.
- doi: 10.1038/emm.2017.193
Heme oxygenase-1-derived carbon monoxide prevents inflammatory vascular disorders. To date, there is no clear evidence that HO-1/CO prevents endothelial dysfunction associated with the downregulation of endothelial NO synthesis in human... -
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- Changes in Histopathology and Tumor Necrosis Factor-αLevels in the Hearts of Rats Following Asphyxial Cardiac Arrest
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Lee JH, Lee TK, Kim IH, Lee JC, Won MH, Park JH, Ahn JH, Shin MC, Ohk TG, Moon JB, Cho JH, Park CW, Tae HJ
- KMID: 2394393
- J Korean Soc Emerg Med.
- 2017 Oct;28(5):449-456.
- doi: 10.0000/jksem.2017.28.5.449
PURPOSE: Post cardiac arrest (CA) syndrome is associated with a low survival rate in patients who initially have a return of spontaneous circulation (ROSC) after the CA. The aim of... -
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- Changes in histopathology and tumor necrosis factor-α levels in the hearts of rats following asphyxial cardiac arrest
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Lee JH, Lee TK, Kim IH, Lee JC, Won MH, Park JH, Ahn JH, Shin MC, Ohk TG, Moon JB, Cho JH, Park CW, Tae HJ
- KMID: 2401245
- Clin Exp Emerg Med.
- 2017 Sep;4(3):160-167.
- doi: 10.15441/ceem.17.220
OBJECTIVE: Post cardiac arrest (CA) syndrome is associated with a low survival rate in patients who initially have return of spontaneous circulation (ROSC) after CA. The aim of this study... -
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- Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils
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Ahn JH, Lee TK, Park JH, Cho JH, Kim IH, Lee JC, Hong S, Jeon YH, Kang IJ, Lee YJ, Won MH, Lee CH
- KMID: 2391097
- Lab Anim Res.
- 2017 Sep;33(3):237-243.
- doi: 10.5625/lar.2017.33.3.237
Myelin degeneration is one of the characteristics of aging and degenerative diseases. This study investigated age-related alterations in expression of myelin basic protein (MBP) in the hippocampal subregions (dentate gyrus,... -
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