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Unveiling the impact of lysosomal ion channels: balancing ion signaling and disease pathogenesis

Jung Y, Kim W, Shin NK, Bae YM, Wie J

Ion homeostasis, which is regulated by ion channels, is crucial for intracellular signaling. These channels are involved in diverse signaling pathways, including cell proliferation, migration, and intracellular calcium dynamics. Consequently,...
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Association between Ultrasonography Findings and Abnormal Karyotypes in Early Pregnancy Loss

Pae J, Park J, Kim S, Kim R, Wie J, Ko HS, Park IY, Shin JC

Objective: Chromosomal abnormality in the fetus is a major cause of early pregnancy loss (EPL). It is considered that maternal age is a risk factor of chromosomal abnormality in the...
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Englerin A-sensing charged residues for transient receptor potential canonical 5 channel activation

Jeong S, Ko J, Kim M, Park KC, Park EY, Kim J, Baik Y, Wie J, Cho AE, Jeon JH, So I

The transient receptor potential canonical (TRPC) 5 channel, known as a nonselective cation channel, has a crucial role in calcium influx. TRPC5 has been reported to be activated by muscarinic...
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