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Vagal Transient Receptor Potential Ankyrin 1 Mediates Stress-exacerbated Visceral Mechanonociception After Antral Cold Exposure

Chen X, Luo Q, Yan X, Li W, Chen S

  • KMID: 2454643
  • J Neurogastroenterol Motil.
  • 2019 Jul;25(3):442-460.
  • doi: 10.5056/jnm19014
BACKGROUND/AIMS: Abdominal pain can be evoked or exacerbated after gastrointestinal cold stimulation in some patients with diarrhea-predominant irritable bowel syndrome (IBS-D), indicating a low temperature-induced sensitization of visceral perception. We...
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Analgesic effects of eucalyptus essential oil in mice

Lee G, Park J, Kim MS, Seol GH, Min SS

BACKGROUND: The use of aroma oils dates back to at least 3000 B.C., where it was applied to mummify corpses and treat the wounds of soldiers. Since the 1920s, the...
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Understanding Neurogastroenterology From Neuroimaging Perspective: A Comprehensive Review of Functional and Structural Brain Imaging in Functional Gastrointestinal Disorders

Kano M, Dupont P, Aziz Q, Fukudo S

  • KMID: 2422842
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):512-527.
  • doi: 10.5056/jnm18072
This review provides a comprehensive overview of brain imaging studies of the brain-gut interaction in functional gastrointestinal disorders (FGIDs). Functional neuroimaging studies during gut stimulation have shown enhanced brain responses...
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Regional Brain Activity During Rest and Gastric Water Load in Subtypes of Functional Dyspepsia: A Preliminary Brain Functional Magnetic Resonance Imaging Study

Chen Y, Wang R, Hou B, Feng F, Fang X, Zhu L, Sun X, Wang Z, Ke M

  • KMID: 2413103
  • J Neurogastroenterol Motil.
  • 2018 Apr;24(2):268-279.
  • doi: 10.5056/jnm17076
BACKGROUND/AIMS: Functional dyspepsia (FD) remains a great clinical challenge since the FD subtypes, defined by Rome III classification, still have heterogeneous pathogenesis. Previous studies have shown notable differences in visceral...
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Bifidobacterium longum and Lactobacillus helveticus Synergistically Suppress Stress-related Visceral Hypersensitivity Through Hypothalamic-Pituitary-Adrenal Axis Modulation

Ait-Belgnaoui A, Payard I, Rolland C, Harkat C, Braniste V, Théodorou V, Tompkins T

  • KMID: 2417281
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):138-146.
  • doi: 10.5056/jnm16167
BACKGROUND/AIMS: Visceral pain and hypothalamic-pituitary-adrenal axis (HPA) dysregulation is a common characteristic in irritable bowel syndrome (IBS) patients. Previously, we reported that a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium...
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Mechanisms of Stress-induced Visceral Pain

Greenwood-Van Meerveld B, Johnson AC

  • KMID: 2417268
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):7-18.
  • doi: 10.5056/jnm17137
Evidence suggests that long-term stress facilitates visceral pain through sensitization of pain pathways and promotes chronic visceral pain disorders such as the irritable bowel syndrome (IBS). This review will describe...
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Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root Ganglion Neurons Innervating the Rat Stomach

Li M, Xue L, Zhu HY, Wang H, Xu X, Zhang PA, Wu G, Xu GY

  • KMID: 2387838
  • J Neurogastroenterol Motil.
  • 2017 Jul;23(3):464-476.
  • doi: 10.5056/jnm16161
BACKGROUND/AIMS: Gastric hypersensitivity contributes to abdominal pain in patients with functional dyspepsia. Recent studies showed that hormones induced by stress are correlated with visceral hypersensitivity. However, the precise mechanisms underlying...
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Piezo2: A Candidate Biomarker for Visceral Hypersensitivity in Irritable Bowel Syndrome?

Bai T, Li Y, Xia J, Jiang Y, Zhang L, Wang H, Qian W, Song J, Hou X

  • KMID: 2387837
  • J Neurogastroenterol Motil.
  • 2017 Jul;23(3):453-463.
  • doi: 10.5056/jnm16114
BACKGROUND/AIMS: Currently, there exists no biomarker for visceral hypersensitivity in irritable bowel syndrome (IBS). Piezo proteins have been proven to play an important role in the mechanical stimulation to induce...
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Surgical excision of the breast giant fibroadenoma under regional anesthesia by Pecs II and internal intercostal plane block: a case report and brief technical description: a case report

Kim H, Shim J, Kim I

A 22-years-old female patient at 171 cm and 67 kg visited the Department of Breast Surgery of the hospital with a mass accompanied with pain on the left side breast...
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Effect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Rats

Lee SP, Lee OY, Lee KN, Lee HL, Choi HS, Yoon BC, Jun DW

  • KMID: 2367462
  • J Neurogastroenterol Motil.
  • 2017 Jan;23(1):109-116.
  • doi: 10.5056/jnm16003
BACKGROUND/AIMS: Post-operative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain....
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Dai-Kenchu-To, a Herbal Medicine, Attenuates Colorectal Distention-induced Visceromotor Responses in Rats

Nakaya K, Nagura Y, Hasegawa R, Ito H, Fukudo S

  • KMID: 2433462
  • J Neurogastroenterol Motil.
  • 2016 Oct;22(4):686-693.
  • doi: 10.5056/jnm15190
BACKGROUND/AIMS: Dai-kenchu-to (DKT), a traditional Japanese herbal medicine, is known to increase gastrointestinal motility and improve ileal function. We tested our hypotheses that (1) pretreatment with DKT would block the...
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The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments

Farzaei MH, Bahramsoltani R, Abdollahi , Rahimi R

  • KMID: 2433449
  • J Neurogastroenterol Motil.
  • 2016 Oct;22(4):558-574.
  • doi: 10.5056/jnm16001
Irritable bowel syndrome (IBS) is the most common disorder referred to gastroenterologists and is characterized by altered bowel habits, abdominal pain, and bloating. Visceral hypersensitivity (VH) is a multifactorial process...
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Oxycodone vs. fentanyl in the treatment of early post-operative pain after total knee replacement: randomized controlled trial

Yang SA, Kim KS, Kang HY

BACKGROUND: Total knee replacement is often accompanied by severe post-operative pain. Oxycodone has sufficient analgesic effects and somewhat greater, but tolerable side effects compared to fentanyl. However, most studies on...
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Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside

Zhang L, Song J, Hou X

  • KMID: 2203567
  • J Neurogastroenterol Motil.
  • 2016 Apr;22(2):181-192.
  • doi: 10.5056/jnm15137
Irritable bowel syndrome (IBS) is traditionally defined as a functional disorder since it lacks demonstrable pathological abnormalities. However, in recent years, low grade inflammatory infiltration, often rich in mast cells,...
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Endovascular Stent Placement in a Patient with a Posttraumatic Isolated Superior Mesenteric Artery Dissection with Focally Progressing Dissecting Aneurysms and a Severely Compressed True Lumen

Kim YK, Her KH, Kim SH, Kim K

Reports on a posttraumatic isolated superior mesenteric artery (SMA) dissection are rare. Recently, endovascular stent placement via percutaneous access, instead of vascular surgery, has been widely accepted as the initial...
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The relationship of preoperative anxiety with failure of extension of epidural analgesia for cesarean section

Yoon HJ, Park SI

BACKGROUND: Patients anesthetized by extension of epidural analgesia during labor frequently experience intraoperative visceral pain during cesarean section. Visceral pain is known to be related to anxiety. We evaluated pain...
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Visceral Pain and Gastrointestinal Microbiome

Chichlowski M, Rudolph C

  • KMID: 2381249
  • J Neurogastroenterol Motil.
  • 2015 Apr;21(2):172-181.
  • doi: 10.5056/jnm15025
A complex set of interactions between the microbiome, gut and brain modulate responses to visceral pain. These interactions occur at the level of the gastrointestinal mucosa, and via local neural,...
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Role of MicroRNA in Visceral Pain

Zhang J, Banerjee B

  • KMID: 2381248
  • J Neurogastroenterol Motil.
  • 2015 Apr;21(2):159-171.
  • doi: 10.5056/jnm15027
The long-lasting nociceptive transmission under various visceral pain conditions involves transcriptional and/or translational alteration in neurotransmitter and receptor expression as well as modification of neuronal function, morphology and synaptic connections....
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Role of Principal Ionotropic and Metabotropic Receptors in Visceral Pain

Kannampalli P, Sengupta J

  • KMID: 2381247
  • J Neurogastroenterol Motil.
  • 2015 Apr;21(2):147-158.
  • doi: 10.5056/jnm15026
Visceral pain is the most common form of pain caused by varied diseases and a major reason for patients to seek medical consultation. It also leads to a significant economic...
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Alternative Method of Retrocrural Approach during Celiac Plexus Block Using a Bent Tip Needle

An JW, Choi EK, Park CH, Choi JB, Ko DK, Lee YW

BACKGROUND: This study sought to determine safe ranges of oblique angle, skin entry point and needle length by reviewing computed tomography (CT) scans and to evaluate the usefulness of a...
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