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Peripheral Neuropathy and Pain Caused by Cancer Chemotherapy

Choi K, Oh J

Peripheral neuropathy and pain are common adverse effects of chemotherapy, which incidence are rising significantly commensurate with extension of survival period in cancer patients. Chemotherapy-induced peripheral neuropathy is caused by...
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Antinociceptive effects of oleuropein in experimental models of neuropathic pain in male rats

Chen H, Ma D, Zhang H, Tang Y, Wang J, Li R, Wen W, Zhang Y

Background: The present investigation explored the therapeutic actions of oleuropein along with the possible signaling pathway involved in attenuating neuropathic pain in chronic constriction injury (CCI) and vincristine-induced neuropathic pain...
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Successful Management of Visceral Kaposiform Hemangioendothelioma with Kasabach‐Merritt Phenomenon Using Corticosteroids and Vincristine

Gang MH, Lim YJ, Chang My

Kaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular neoplasm that often develops a coagulopathy known as Kasabach­Merritt phenomenon (KMP). Visceral involvement denotes a poor prognosis. We report a case...
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Antiallodynic and anti-inflammatory effects of intrathecal R-PIA in a rat model of vincristine-induced peripheral neuropathy

Kim K, Jeong W, Jun IG, Park JY

Background: Studies investigating the correlation between spinal adenosine A1 receptors and vincristine-induced peripheral neuropathy (VIPN) are limited. This study explored the role of intrathecal N6-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA) in the rat...
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Characteristics of Peripheral Polyneuropathy after Chemotherapy in Pediatric Acute Lymphoblastic Leukemia

Min YS, Kang MG, Kim JY

BACKGROUND: Vincristine is an antimitotic agent used for treatment of leukemia, lymphomas, and cancers. Its main side effect is a dose-related, length-dependent axonal neuropathy. METHODS: We performed electrodiagnostic examinations in 18...
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Two Cases of External Ophthalmoplegia after Vincristine Treatment in Childhood

Lee DH, Jung JH

PURPOSE: To report 2 cases of extraocular muscle paresis with ptosis after vincristine treatment in childhood with acute leukemia. CASE SUMMARY: A 4-year-old girl with acute lymphoblastic leukemia experienced diplopia, esotropia...
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Application of vincristine-loaded platelet therapy in three dogs with refractory immune-mediated thrombocytopenia

Park HJ, Kim JW, Song KH, Seo KW

Three dogs presented with refractory immune-mediated thrombocytopenia (IMT). All patients failed to respond to prednisone, which is considered a mainstay of immunosuppressive therapy. Vincristine-loaded platelets (VLPs), which act selectively on...
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Procarbazine, CCNU, and Vincristine Chemotherapy in Gliomatosis Cerebri

Lee HG, Lee KS, Lee WH, Kim ST

A 49-year-old female patient was admitted due to memory disturbances. Magnetic resonance (MR) imaging suggested gliomatosis cerebri (GC), which had spread to both insular lobes, both frontal and basal ganglia...
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The Role of Chemotherapy in Anaplastic Astrocytoma Patients

Kim SK, Kim JW, Kim YH, Kim TM, Lee SH, Park CK

OBJECTIVE: This retrospective study was performed to evaluate the role of chemotherapy in the management of patients with anaplastic astrocytoma (AA). METHODS: We compared the survival outcome among the 3 different...
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Analgesic Effects of Dexmedetomidine in Vincristine-Evoked Painful Neuropathic Rats

Park HJ, Kim YH, Koh HJ, Park CS, Kang SH, Choi JH, Moon DE

Dexmedetomidine, which is a selective alpha2-adrenoceptor agonist, was recently introduced into clinical practice for its analgesic properties. The purpose of this study was to evaluate the effects of dexmedetomidine in...
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Antinociceptive Effect of Memantine and Morphine on Vincristine-induced Peripheral Neuropathy in Rats

Park BY, Park SH, Kim WM, Yoon MH, Lee HG

BACKGROUND: Vincristine-induced peripheral neuropathy is a major dose limiting side effect and thus effective therapeutic strategy is required. In this study, we investigated the antinociceptive effect of memantine and morphine...
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A case of vincristine-induced polyneuropathy in an patient with acute leukemia

Back SY, Park BB, Park DW, Kim JH, Jung KH, Kim HY, Park SY

  • KMID: 2257628
  • Korean J Med.
  • 2009 May;76(5):611-616.
When neurological symptoms occur during the treatment of acute lymphoblastic leukemia, the differential diagnosis includes a leukemic infiltration of the nervous system, drug toxicity, infection, and other neurological disorders. We...
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Abducens Nerve Palsy Induced by Chemotherapeutic Agents

Park JM

  • KMID: 2337750
  • J Korean Ophthalmol Soc.
  • 2008 Nov;49(11):1871-1876.
PURPOSE: To report two cases of abducens nerve palsy that occurred after the administration of chemotherapeutic agents. CASE SUMMARY: (Case 1) A 49-year-old woman with breast cancer presented with acute onset...
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Combination chemotherapy with topotecan and vincristine for patients with refractory or recurrent small cell lung cancer

Ahn HS, Won HJ, Lee HR, Yuh YJ, Kim SR

  • KMID: 2081281
  • Korean J Med.
  • 2007 Jun;72(6):632-638.
BACKGROUDN: Small cell lung cancer (SCLC) is a chemotherapy-sensitive tumor. However, the duration of response is usually short and most patients experience relapses. Topotecan is commonly used for treatment of...
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Gene Expression Changes of Drug-resistant Saos-2 Cells Induced by Anticancer Drug

Bae MJ, Song IH, Kim SY

  • KMID: 2128893
  • Korean J Anat.
  • 2007 Dec;40(4):297-310.
During the treatment of cancers, especially with anticancer drugs, the recurrence of cancer is the most important factor for survival rate. The most common cause of the recurrence is the...
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Vincristine Effect for the Treatment of Idiopathic Thrombocytopenic Purpura in Childhood

Hong CH, Park JK, Lee SY

  • KMID: 2279912
  • Clin Pediatr Hematol Oncol.
  • 2007 Oct;14(2):151-158.
PURPOSE: The aim of this study was to evaluate the effect of vincristine for the patients with idiopathic thrombocytopenic purpura (ITP), who were resistant to both intravenous methylprednisolone (IVMP) and...
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Neoadjuvant chemotherapy with mitomycin-C, vincristine and cisplatin (MVC) for patients with loco-regionally advanced cervical carcinoma

Choi CH, Kim TJ, Lee JW, Kim BG, Lee JH, Bae DS

  • KMID: 2143521
  • Korean J Gynecol Oncol.
  • 2006 Mar;17(1):15-21.
OBJECTIVE: The efficacy and toxicity of neoadjuvant chemotherapy (NAC) with mitomycin-C, vincristine and cisplatin (MVC) were assessed in bulky cervical carcinoma patients. METHODS: Forty-six patients with stage Ib2 to IIb bulky...
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Platelet count change by vincristine in maintenance phase of acute lymphoblastic leukemia chemotherapy

Lee SM, Ham SS, Jeon IS

PURPOSE: The hematologic change during the treatment of acute lymphoblastic leukemia(ALL) is critical as a prognostic determinant and a variable to determine the dose of chemotherapeutic agents. It is known...
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Successful Management with Vincristine after Failure of Prednisolone Therapy for Diffuse Neonatal Hemangiomatosis

Lee HS, Heo SY, Kim WD

  • KMID: 2279057
  • Korean J Pediatr.
  • 2005 Sep;48(9):1004-1008.
Hemangiomas are the most common benign tumors of infancy. Fifteen to 30% of these patients have multiple hemangiomas. Diffuse neonatal hemangiomatosis (DNH) is a disease that often has a fatal...
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Phase II Study of Cyclophosphamide, Epirubicin, Vincristine, Prednisone, and Etoposide (CEOP-E) for Aggressive Non-Hodgkin 's Lymphoma

Kim JG, Sohn SK, Kim DH, Baek JH, Park TI, Lee KB

The main objectives of the current study were to evaluate the efficacy and safety of a CEOP-E regimen for patients with aggressive non-Hodgkin's lymphoma (NHL). Fifty-one consecutive patients with newly...
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