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Nicardipine Augments Local Myocardial Perfusion after Coronary Artery Reperfusion in Dogs

Jang YH, Kim JM

Nicardipine is a potent coronary and systemic vasodilator without depression of ventricular function. We investigated the changes in local myocardial perfusion (LMP) according to the nicardipine administration after coronary reperfusion...
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Serotonin and pancreatic duct function

Naruse S, Suzuki A, Ishiguro H, Kitagawa M, Ko SB, Yoshikawa , Yamamoto A, Hamada H, Hayakawa T

1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT...
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Mechanism of UV light-induced photorelaxation in isolated rat aorta

Kim JH, Hong Y, Shim CS

  • KMID: 1094645
  • J Vet Sci.
  • 2000 Dec;1(2):81-86.
Isolated rat thoracic aorta which is pharmacologically precontracted by phenylephrine induces photorelaxation when exposed to long wave length UV-light. The aim of the present study was to characterize the mechanism...
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[Na+]i, [K+]i and [Cl-]i regulation of exocytosis in guinea-pig antral mucous cells

Nakahari T, Fujiwara S, Shimamoto

Effects of intracellular Na+, K+ and Cl- on Ca(2+)-regulated exocytosis activated by 10 microM acetylcholine (ACh) were studied in guinea-pig antral mucous cells which are permeabilized by nystatin treatment. Ca(2+)-regulated...
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Inhibitory Effects of Potassium Channel Blockers on Carbachol-induced Contraction in Rat Detrusor Muscle

Oh SJ, Ahn SC

We present accidental findings that potassium channel blockers, such as tetraethyl-ammonium (TEA) or 4-aminopyridine (4-AP), inhibit the sustained tonic contraction induced by carbachol in rat detrusor muscle strips. The relatively...
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Erythropoietin does not affect nitric oxide system in rats with chronic renal failure

Kim SW, Lee JU, Kang DG, Jung K, Kim NH, Suh SP, Choi KC, Kang YJ

We investigated to see whether an altered role of nitric oxide (NO) system is involved in erythropoietin (EPO)-induced hypertension in chronic renal failure (CRF). Male Sprague-Dawley rats were five-sixths nephrectomized...
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The involvement of K+ channels and the possible pathway of EDHF in the rabbit femoral artery

Kwon SC, Pyun WB, Park GY, Choi HK, Paik KS, Kang BS

Experiments were designed to characterize the cellular mechanisms of action of endothelium-derived vasodilator substances in the rabbit femoral artery. Acetylcholine (ACh, 10(-8)-10(-5) M) induced a concentration-dependent relaxation...
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Increased basal tone and hyperresponsiveness to acetylcholine and ergonovine in spasm related coronary arteries in patients with variant angina: basal coronary artery tone in patients with variant angina

Park SJ, Park SW, Kim JJ, Song JK, Hong MK, Kang DH, Cheong SS, Lee CW, Lee JK

In patients with variant angina, previous data have been inconclusive as to whether basal coronary artery tone is elevated at the spastic and non-spastic sites. Thus, the purpose of this...
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Estrogen affects vascular tone differently according to vasoactive substances in ovariectomized Sprague-Dawley rat

Seo B, Ikeda K, Emoto N, Choi DJ, Hwang JY, Matsuo M, Kim EJ, Cheon IS

The favorable effects of estrogen on cardiovascular diseases can be explained by several mechanisms such as changes in serum lipid profiles and thrombogenecity. Estrogen also affects the vascular tone, but...
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ATP-induced focal adhesion kinase activity is negatively modulated by phospholipase D2 in PC12 cells

Bae YS, Ryu SH

  • KMID: 938879
  • Exp Mol Med.
  • 2001 Sep;33(3):150-155.
Extracellular ATP has been known to modulate various cellular responses including mitogenesis, secretion and morphogenic activity in neuronal cells. In the ATP-induced morphogenic activity, focal adhesion kinase(s) such as Fak...
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All-trans-retinoic acid attenuates neointima formation with acceleration of reendothelialization in balloon-injured rat aorta

Lee CW, Park SJ, Park SW, Kim JJ, Hong MK, Song JK

Retinoic acids may inhibit vascular smooth muscle cell proliferation, but may promote endothelial cell proliferation in cell culture. However, little data are available about the effects of all-trans-retinoic acid (ATRA)...
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