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Effects of hypoxia on pulmonary vascular contractility

Lee YH, Seo JH, Kang BS

Although hypoxic pulmonary vasoconstriction (HPV) has been recognized by many researchers, the precise mechanism remains unknown. As isolated pulmonary arteries will constrict in vitro in the response to hypoxia, the...
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PGF2 alpha causes bronchoconstriction and pulmonary vasoconstriction via thromboxane receptors in rat lung

Kang KH, Shim JJ, Banerjee M, Newman JH

  • KMID: 1038466
  • Korean J Intern Med.
  • 1996 Jan;11(1):74-81.
We determined the vascular and airway effects of PGF2 alpha and its mechanism of action on isolated-perfused lungs of rats were isolated and perfused at 50 ml/kg/min with Krebs-Henseleit bicarbonate...
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Erythropoietin does not affect nitric oxide system in rats with chronic renal failure

Kim SW, Lee JU, Kang DG, Jung K, Kim NH, Suh SP, Choi KC, Kang YJ

We investigated to see whether an altered role of nitric oxide (NO) system is involved in erythropoietin (EPO)-induced hypertension in chronic renal failure (CRF). Male Sprague-Dawley rats were five-sixths nephrectomized...
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Increased basal tone and hyperresponsiveness to acetylcholine and ergonovine in spasm related coronary arteries in patients with variant angina: basal coronary artery tone in patients with variant angina

Park SJ, Park SW, Kim JJ, Song JK, Hong MK, Kang DH, Cheong SS, Lee CW, Lee JK

In patients with variant angina, previous data have been inconclusive as to whether basal coronary artery tone is elevated at the spastic and non-spastic sites. Thus, the purpose of this...
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Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged mice

Shin W, Berkowitz , Ryoo S

  • KMID: 1506223
  • Exp Mol Med.
  • 2012 Oct;44(10):594-602.
The incidence of cardiovascular disease is predicted to increase as the population ages. There is accumulating evidence that arginase upregulation is associated with impaired endothelial function. Here, we demonstrate that...
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