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MicroRNA and Their Potential Role in Conjunctival Disorders

Syed NH, Zunaina E, Wan-Nazatul Shima S, Sharma M, Shatriah I

MicroRNAs (miRNAs) are the small noncoding RNA molecules which regulate target gene expression posttranscriptionally. They are known to regulate key cellular processes like inflammation, cell differentiation, cell proliferation, and cell...
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Noncoding RNAs as therapeutic targets in early stage diabetic kidney disease

Kato M

Diabetic kidney disease (DKD) is a major renal complication of diabetes that leads to renal dysfunction and end-stage renal disease (ESRD). Major features of DKD include accumulation of extracellular matrix...
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The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge

Temian DC, Pop LA, Irimie AI, Berindan-Neagoe I

Breast cancer has the highest incidence among all malignancies diagnosed in women. Therapies have significantly improved over the years due to extensive molecular and clinical research; in a large number...
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Expression Patterns of Circular RNAs from Primary Kinase Transcripts in the Mammary Glands of Lactating Rats

Zhang C, Wu H, Wang Y, Zhao Y, Fang X, Chen C, Chen H

PURPOSE: Circular RNAs (circRNAs), a novel class of RNAs, perform important functions in biological processes. However, the role of circRNAs in the mammary gland remains unknown. The present study is...
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Regulation and Role of EZH2 in Cancer

Yamaguchi , Hung MC

  • KMID: 2167686
  • Cancer Res Treat.
  • 2014 Jul;46(3):209-222.
Polycomb repressive complex 2 (PRC2) is the epigenetic regulator that induces histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription. Enhancer of zeste homolog 2 (EZH2) is an...
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