- Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory disease
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Kong SK, Kim BS, Uhm TG, Chang HS, Park JS, Park SW, Park CS, Chung IY
- KMID: 2327672
- Exp Mol Med.
- 2016 Jan;48(1):e202.
- doi: 10.1038/emm.2015.96
Aspirin hypersensitivity is a hallmark of aspirin-exacerbated respiratory disease (AERD), a clinical syndrome characterized by the severe inflammation of the respiratory tract after ingestion of cyclooxygenase-1 inhibitors. We investigated the... -
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- Eosinophil Development, Regulation of Eosinophil-Specific Genes, and Role of Eosinophils in the Pathogenesis of Asthma
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Uhm TG, Kim BS, Chung IY
- KMID: 2260359
- Allergy Asthma Immunol Res.
- 2012 Mar;4(2):68-79.
- doi: 10.4168/aair.2012.4.2.68
Eosinophils arise from hematopoietic CD34+ stem cells in the bone marrow. They acquire IL-5Ralpha on their surface at a very early stage during eosinophilopoiesis, and differentiate under the strong influence... -
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- CpG methylation at GATA elements in the regulatory region of CCR3 positively correlates with CCR3 transcription
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Uhm TG, Lee SK, Kim BS, Kang JH, Park CS, Rhim TY, Chang HS, Kim DJ, Chung IY
- KMID: 1365904
- Exp Mol Med.
- 2012 Apr;44(4):268-280.
- doi: 10.3858/emm.2012.44.4.022
DNA methylation may regulate gene expression by restricting the access of transcription factors. We have previously demonstrated that GATA-1 regulates the transcription of the CCR3 gene by dynamically interacting with... -
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