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Clinical studies of dapagliflozin in pediatric patients: a rapid review

Grube PM, Beckett RD

The oral sodium-glucose cotransporter 2 inhibitor, dapagliflozin, is used to treat kidney disease, heart failure, and diabetes in adults, but has not been well studied in pediatrics, and does not...
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Factors Affecting Self-management Behavior among Patients with Type 2 Diabetes in a Border Area of Southwest China

Yuan Y, Jun S

Purpose: This study aimed to investigate the status and factors associated with self-management behavior (SMB) of patients with type 2 diabetes (T2DM) in a border area of southwest China. Methods:...
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Old and new classes of glucose-lowering agents as treatments for non-alcoholic fatty liver disease: A narrative review

Miao L, Xu J, Targher G, Byrne CD, Zheng MH

Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease with a global prevalence of about 55% in people with type 2 diabetes mellitus (T2DM). T2DM, obesity...
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Single Point Insulin Sensitivity Estimator for predicting type 2 diabetes mellitus in obese adolescents

Ha J, Oh YR, Kang E, Nam HK, Rhie YJ, Lee KH

Purpose: The prevalence of adolescents with type 2 diabetes mellitus (T2DM) has rapidly increased in Korea over the past few decades with the increase in the number of obese adolescents....
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The role of nutritional status in the relationship between diabetes and health-related quality of life

Park S, Jung S, Yoon H

BACKGROUND/OBJECTIVES: The association between nutritional status and health-related quality of life (HRQoL) among patients with type 2 diabetes mellitus (T2DM) is not fully understood. This study was conducted to understand...
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Effect of the addition of thiazolidinedione to sodium-glucose cotransporter 2 inhibitor therapy on lipid levels in type 2 diabetes mellitus: a retrospective study using Korean National Health Insurance Service data

Park T, Han K, Shin D, Park J

Background: Dyslipidemia is common in patients with type 2 diabetes mellitus (T2D) and contributes to an increased risk of cardiovascular disease. Previous studies have shown that treatment with thiazolidinediones (TZDs)...
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Severe hypoglycemia as a risk factor for cardiovascular outcomes in patients with type 2 diabetes: is it preventable?

Ko SH

Hypoglycemia in people with type 2 diabetes mellitus (T2DM) is troublesome and an important barrier to diabetes management. Although more intensive glycemic control is emphasized to prevent diabetes-related long-term complications,...
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Type 2 Diabetes Remission with Significant Weight Loss: Definition and Evidence-Based Interventions

Ko JH, Kim TN

Type 2 diabetes (T2D) has long been regarded as an incurable and chronic disease according to conventional management methods. Clinical and pathophysiological studies on the natural course of T2D have...
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Correlation of advanced glycation end products and heme oxygenase-1 in Korean diabetic patients

Choi HN, Koo DH, Yim JE

Purpose: Hyperglycemia accelerates the formation of advanced glycation end products (AGEs), a group of compounds formed via non-enzymatic glycation/glycoxidation. Type 2 diabetes mellitus (T2DM) is related to oxidative stress, resulting...
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Does bisphenol-A affect alteration of gut microbiome after bariatric/metabolic surgery?: a comparative metagenomic analysis in a long-term high-fat diet induced-obesity rat model

Son SY, Wang B, Hur H, Kim HH, Han SU

Purpose: Bisphenol A (BPA) is a widely used environmental contaminant that is associated with type 2 diabetes mellitus and a shift of gut microbial community. However, little is known about...
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Sodium Glucose Cotransporter-2 Inhibitors as an Add-on Therapy to Metformin Plus Dipeptidyl Peptidase-4 Inhibitor in Patients with Type 2 Diabetes

Bae J, Kim Ye, Lee M, Lee Yh, Lee BW, Cha BS, Kang ES

Purpose: To date, no study has compared the effects of adding sodium glucose cotransporter-2 (SGLT-2) inhibitors to the combination of metformin plus dipeptidyl peptidase-4 (DPP-4) inhibitors to the effects of...
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GLP-1 receptor agonists in diabetic kidney disease: current evidence and future directions

Yu JH, Park SY, Lee DY, Kim NH, Seo JA

With the emergence of various classes of blood glucose-lowering agents, choosing the appropriate drug for each patient is emphasized in diabetes management. Among incretin-based drugs, glucagon-like peptide 1 (GLP-1) receptor...
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The Impact of Psychological Insulin Resistance on Self-Care Activities in Patients with Type 2 Diabetes Mellitus Undergoing Insulin Therapy

Kim MG, Song HJ

Purpose: The purpose of this study was to identify the level of psychological insulin resistance and self-care activities and to evaluate the factors affecting self-care activities in patients with type...
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Prevalence and Associated Factors of Diabetic Retinopathy among Type 2 Diabetes Mellitus Patients in Brunei Darussalam: A Cross-sectional Study

Raja SA, Chong VH, Rahman NA, Shakir LMP, Knights J

Purpose: To determine the prevalence of diabetic retinopathy (DR) and the factors associated with retinopathy among type 2 diabetes mellitus (DM) patients in Brunei Darussalam. Methods: Cross-sectional study of all type...
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Low Social Support and Risk for Depression in People With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis

Azmiardi A, Murti B, Febrinasari RP, Tamtomo DG

Objectives: Depression is a frequent complication of type 2 diabetes mellitus. This study aimed to investigate the relationship between low social support and risk for depression in people with type...
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Validation and genetic heritability estimation of known type 2 diabetes related variants in the Korean population

Jang HM, Hwang MY, Kim BJ, Kim YJ

Genome-wide association studies (GWASs) facilitated the discovery of countless disease-associated variants. However, GWASs have mostly been conducted in European ancestry samples. Recent studies have reported that these European-based association results...
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Genotype - phenotype correlation in an adolescent girl with pathogenic PPARy genetic variation that caused severe hypertriglyceridemia and early onset type 2 diabetes

Gutierrez Alvarez A, Yachelevich N, Kohn B, Brar PC

Severe hypertriglyceridemia (HTG) (>885 mg/dL) can be caused by familial partial lipodystrophy type 3 (FPLD3), an autosomal dominant disorder caused by loss of function of the peroxisome proliferator-activated receptor gamma...
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Relationship between Type 2 Diabetes Mellitus and Lumbar Bone Mineral Density in Postmenopausal Women

Lee CY, Back GY, Lee SH

Study Design: Cross-sectional study using radiological measurements. Purpose: To analyze the relationship between type 2 diabetes mellitus (DM) and bone mineral density (BMD) in postmenopausal women and to assess risk factors...
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Hyperglycemic Hemichorea: A Case Series

Moon S, Kim HE, Oh TJ, Ahn CH, Choi SH, Jang HC

Hemichorea has been reported in subjects with hyperglycemia and the recurrent was rarely reported. We identified clinical presentation and course of hypeglycemic hemichorea in six cases, one of whom experienced...
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Urinary exosomal microRNA profiling in type 2 diabetes patients taking dipeptidyl peptidase-4 inhibitor compared with sulfonylurea

Cho NJ, Kim DY, Kwon SH, Ha TW, Kim HK, Lee MR, Chun SW, Park S, Lee Ey, Gil HW

Background: Dipeptidyl peptidase-4 (DPP-4) inhibitor has been reported to have kidney-protective benefits. To elucidate how antidiabetic agents prevent diabetic kidney disease progression, it is important to investigate their effect on...
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