- Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase
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Byun HS, Won M, Park KA, Kim YR, Choi BL, Lee H, Hong JH, Piao L, Park J, Kim JM, Kweon GR, Kang SH, Han J, Hur GM
- KMID: 1052941
- Exp Mol Med.
- 2008 Apr;40(2):186-195.
- doi: 10.3858/emm.2008.40.2.186
Previous studies have demonstrated that rottlerin, a specific PKCdelta inhibitor, potentiates death receptor- mediated apoptosis through a cytochrome c-dependent or -independent pathway. However, its ability to regulate necrotic cell death,... -
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- Repression of TNF-alpha-induced IL-8 expression by the glucocorticoid receptor-beta involves inhibition of histone H4 acetylation
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Kim SH, Kim DH, Lavender P, Seo JH, Kim YS, Park JS, Kwak SJ, Jee YK
- KMID: 1123803
- Exp Mol Med.
- 2009 May;41(5):297-306.
- doi: 10.3858/emm.2009.41.5.033
Increased expression of a number of proinflammatory genes, including IL-8, is associated with inflammatory conditions such as asthma. Glucocorticoid receptor (GR)beta, one of the GR isoforms, has been suggested to... -
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