- Murine pro-tumor necrosis factor expressed in Saccharomyces cerevisiae HF7c localizes to membrane/particulate
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Jeong JY, Jue DM
- KMID: 1109303
- Exp Mol Med.
- 2000 Jun;32(2):61-66.
Tumor necrosis factor (TNF) is a cytokine that is produced by immune cells in response to bacterial and viral stimuli and plays important roles in various inflammatory diseases. TNF... -
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- Nuclear factor kappaB (NF-kappaB) pathway as a therapeutic target in rheumatoid arthritis
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Jue DM, Jeon KI, Jeong JY
- KMID: 646299
- J Korean Med Sci.
- 1999 Jun;14(3):231-238.
- doi: 10.3346/jkms.1999.14.3.231
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by persistent joint swelling and progressive destruction of cartilage and bone. Current RA treatments are largely empirical in origin and their... -
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- The Combination of TRAIL Treatment and Cancer Cell Selective Expression of TRAIL-Death Receptor DR4 Induces Cell Death in TRAIL-Resistant Cancer Cells
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Choi E, Kim Y, Kim K
- KMID: 1715873
- Yonsei Med J.
- 2006 Feb;47(1):55-62.
- doi: 10.3349/ymj.2006.47.1.55
The human telomerase reverse transcriptase (hTERT) promoter can be used for the tumor-specific expression of transgenes in order to induce selective cancer cell death. The hTERT core promoter is active... -
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- Genetic factors associated with development of cerebral malaria and fibrotic schistosomiasis
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Hirayama K
- KMID: 1384728
- Korean J Parasitol.
- 2002 Dec;40(4):165-172.
- doi: 10.3347/kjp.2002.40.4.165
Collaborative studies have identified some genetic factors contributing to the development of severe forms of malaria and schistosomiasis. In Thailand, the TNF-alpha 5'-flanking region shows biallelic polymorphic sites at nucleotides... -
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- Human hepatocellular carcinoma cells resist to TRAIL-induced apoptosis, and the resistance is abolished by cisplatin
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Shin EC, Seong YR, Kim CH, Kim H, Ahn YS, Kim K, Kim SJ, Hong SS, Park JH
- KMID: 1081460
- Exp Mol Med.
- 2002 May;34(2):114-122.
TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF family, selectively induce apoptosis in various transformed cell lines but not in almost-normal tissues. It is regulated by 2 death receptors,... -
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- In vivo ligation of glucocorticoid-induced TNF receptor enhances the T-cell immunity to herpes simplex virus type 1
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La S, Kim E, Kwon B
- KMID: 1056231
- Exp Mol Med.
- 2005 Jun;37(3):193-198.
GITR (glucocorticoid-induced TNF receptor) is a recently identified member of the TNF receptor superfamily. The receptor is preferentially expressed on CD4+CD25+ regulatory T cells and GITR signals break the suppressive... -
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- An antioxidant modulates expression of receptor activator of NF-kappaB in asthma
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Lee KS, Park HS, Park SJ, Kim SR, Min KH, Jin SM, Li L, Lee YC
- KMID: 1094147
- Exp Mol Med.
- 2006 Jun;38(3):217-229.
Oxidative stress plays critical roles in airway inflammation that is usually accompanied by increased vascular permeability and plasma exudation. VEGF increases vascular permeability and leads to airway inflammation. In addition,... -
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