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Human Pluripotent Stem Cell-Derived Alveolar Organoids: Cellular Heterogeneity and Maturity

Jung Jh, Yang SR, Kim WJ, Rhee CK, Hong SH

Chronic respiratory diseases such as idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and respiratory infections injure the alveoli; the damage evoked is mostly irreversible and occasionally leads to death. Achieving...
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Subphenotypes of Acute Respiratory Distress Syndrome: Advancing Towards Precision Medicine

Levine AR, Calfee CS

Acute respiratory distress syndrome (ARDS) is a common cause of severe hypoxemia defined by the acute onset of bilateral non-cardiogenic pulmonary edema. The diagnosis is made by defined consensus criteria....
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Clinical Utility of Chest Sonography in Chronic Obstructive Pulmonary Disease Patients Focusing on Diaphragmatic Measurements

Esmaeel HM, Atta KA, khalaf S, Gadallah D

Background: There are many methods of evaluating diaphragmatic function, including trans-diaphragmatic pressure measurements, which are considered the key rule of diagnosis. We studied the clinical usefulness of chest ultrasonography in...
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Perception of Long-Term Oxygen Therapy for Chronic Lung Diseases May Affect Poor Adherence in Korea

Kim HJ, Lee H, Yang JY, Lee JH, Ra Sw, Hong S, Lee HY, Kim SH, Kim MY, Lee HK

Background: Long-term oxygen therapy (LTOT) improves the survival of patients with hypoxemia due to chronic respiratory diseases. The clinical outcomes of LTOT are strongly associated with patient adherence. To improve...
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Recent Advances in Adjuvant Therapy for Non–Small-Cell Lung Cancer

Kim MH, Kim SH, Lee MK, Eom JS

After the successful development of targeted therapy and immunotherapy for the treatment of advanced-stage non-small cell lung cancer (NSCLC), these innovative treatment options are rapidly being applied in the adjuvant...
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Diagnostic Accuracy of Lactate Dehydrogenase/Adenosine Deaminase Ratio in Differentiating Tuberculous and Parapneumonic Effusions: A Systematic Review

Nyanti LE, Rahim MAA, Huan NC

Background: Tuberculous pleural effusion (TPE) and parapneumonic effusion (PPE) are often difficult to differentiate owing to the overlapping clinical features. Observational studies demonstrate that the ratio of lactate dehydrogenase to...
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Tailored Biologics Selection in Severe Asthma

Kim SH, Kim Y

The management of severe asthma presents a significant challenge in asthma treatment. Over the past few decades, remarkable progress has been made in developing new treatments for severe asthma, primarily...
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Immune Evasion of G-CSF and GM-CSF in Lung Cancer

Park Y, Chung C

Tumor immune evasion is a complex process that involves various mechanisms, such as antigen recognition restriction, immune system suppression, and T cell exhaustion. The tumor microenvironment contains various immune cells...
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Diagnostic Approaches for Idiopathic Pulmonary Fibrosis

Lee JH, Song JW

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia with a very poor prognosis. Accurate diagnosis of IPF is essential for good outcomes but remains a major medical...
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Roles of Inflammatory Biomarkers in Exhaled Breath Condensates in Respiratory Clinical Fields

Choi YJ, Lee MJ, Byun MK, Park S, Park J, Park D, Kim SH, Kim Y, Lim SY, Yoo KH, Jung KS, Park HJ

Background: Exhaled condensates contain inflammatory biomarkers; however, their roles in the clinical field have been under-investigated. Methods: We prospectively enrolled subjects admitted to pulmonology clinics. We collected exhaled breath condensates (EBC)...
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