- Activation of caspase-8 in 3-deazaadenosine-induced apoptosis of U-937 cells occurs downstream of caspase-3 and caspase-9 without Fas receptor-ligand interaction
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Chae YJ, Kim HS, Rhim HS, Kim BE, Jeong SW, Kim IK
- KMID: 1457543
- Exp Mol Med.
- 2001 Dec;33(4):284-292.
3-Deazaadenosine (DZA), a cellular methylation blocker was reported to induce the caspase-3-like activities-dependent apoptosis in U-937 cells. In this study, we analyzed the activation pathway of the caspase cascade involved... -
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- Induction of apoptosis in human leukemia cells by 3-deazaadenosine is mediated by caspase-3-like activity
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Kim HS, Jeong SY, Lee JH, Kim BE, Kim JW, Jeong SW, Kim IK
- KMID: 755099
- Exp Mol Med.
- 2000 Dec;32(4):197-203.
3-Deazaadenosine (DZA), one of the potent inhibitors of S-adenosylhomocysteine hydrolase, is known to possess several biological properties including an induction of apoptosis. To evaluate a possibility that DZA... -
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