- Common data model-based real-world data for practical clinical practice guidelines: clinical pharmacology perspectives
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Jeon Y, Choi Y, Kim EH, Oh S, Lee H
- KMID: 2505152
- Transl Clin Pharmacol.
- 2020 Jun;28(2):67-72.
- doi: 10.12793/tcp.2020.28.e11
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- Validation of “sasLM,” an R package for linear models with type III sum of squares
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Sunwoo J, Kim H, Choi D, Bae KS
- KMID: 2505154
- Transl Clin Pharmacol.
- 2020 Jun;28(2):83-91.
- doi: 10.12793/tcp.2020.28.e9
The general linear model (GLM) describes the dependent variable as a linear combination of independent variables and an error term. The GLM procedure of SAS® and the “car” package in... -
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- Development and validation of a method for the simultaneous quantification of endogenous steroids metabolized by CYP3A
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Lee Y, Chae W, Yoon S, Chung JY, Cho JY
- KMID: 2505153
- Transl Clin Pharmacol.
- 2020 Jun;28(2):73-82.
- doi: 10.12793/tcp.2020.28.e10
Cytochrome P450 (CYP) 3A enzymes, the most important phase 1 drug-metabolizing enzymes, are responsible for 50% of the metabolism of clinically used drugs. CYP3A activity varies widely among individuals, which... -
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- Pharmacokinetics and bioequivalence of fixed-dose combination of candesartan cilexetil/amlodipine besylate (16/10 mg) versus coadministration of individual formulations in healthy subjects
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Lee HW, Kang WY, Jung W, Gwon MR, Yang DH, Kim EH, Cho K, Yoon YR, Seong SJ
- KMID: 2505155
- Transl Clin Pharmacol.
- 2020 Jun;28(2):92-101.
- doi: 10.12793/tcp.2020.28.e8
This study compared the pharmacokinetics of a fixed-dose combination (FDC) of candesartan (16 mg) and amlodipine (10 mg) versus coadministration of individual formulations to clarify the bioequivalence of the FDC.... -
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- Pharmacokinetic comparison of two bazedoxifene acetate 20 mg tablet formulations in healthy Korean male volunteers
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Yeun JS, Kan HS, Lee M, Kim N, Oh TY, Nam SK, Choi YS, Kwon IS, Hong JH
- KMID: 2505156
- Transl Clin Pharmacol.
- 2020 Jun;28(2):102-108.
- doi: 10.12793/tcp.2020.28.e7
Bazedoxifene, used as bazedoxifene acetate, is a selective estrogen receptor modulator that selectively affects the uterus, breast tissue, bone metabolism, and lipid metabolism by antagonizing or enhancing estrogens in the... -
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