- Hydrogen sulfide alleviates hypothyroidism-induced myocardial fibrosis in rats through stimulating autophagy and inhibiting TGF-β1/Smad2 pathway
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Song X, Nie L, Long J, Zhao J, Liu X, Wang L, Liu D, Wang S, Liu S, Yang J
- KMID: 2537498
- Korean J Physiol Pharmacol.
- 2023 Jan;27(1):1-8.
- doi: 10.4196/kjpp.2023.27.1.1
Hypothyroidism alone can lead to myocardial fibrosis and result in heart failure, but traditional hormone replacement therapy does not improve the fibrotic situation. Hydrogen sulfide (H 2 S), a new... -
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- Histological Changes of Cervical Disc Tissue in Patients with Degenerative Ossification
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Xiong Y, Yang YL, Gao YS, Wang XM, Yu X
- KMID: 2527175
- J Korean Neurosurg Soc.
- 2022 Mar;65(2):186-195.
- doi: 10.3340/jkns.2021.0082
Objective : To explore the histological feature of the cervical disc degeneration in patients with degenerative ossification (DO) and its potential mechanisms. Methods : A total of 96 surgical segments, from... -
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- EW-7197 Attenuates the Progression of Diabetic Nephropathy in db/db Mice through Suppression of Fibrogenesis and Inflammation
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Ha KB, Sangartit W, Jeong AR, Lee ES, Kim HM, Shim S, Kukongviriyapan U, Kim DK, Lee EY, Chung CH
- KMID: 2527141
- Endocrinol Metab.
- 2022 Feb;37(1):96-111.
- doi: 10.3803/EnM.2021.1305
Background: Diabetic nephropathy (DN) is characterized by albuminuria and accumulation of extracellular matrix (ECM) in kidney. Transforming growth factor-β (TGF-β) plays a central role in promoting ECM accumulation. We aimed... -
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- Prenatal Diagnosis of an Ascending Aortic Aneurysm Inherited from the Father: A Case Report of Loeys-Dietz Syndrome Type 1
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Sim YK, Lee DH, Kim JK, Chae HS, Lee JH, Jeong YJ
- KMID: 2522533
- Perinatology.
- 2021 Sep;32(3):151-155.
- doi: 10.14734/PN.2021.32.3.151
Inherited aortic aneurysms are very rare during fetal life. If an aortic aneurysm is seen on prenatal ultrasound, the differential diagnosis of hereditable connective tissue disorders, such as Loeys-Dietz syndrome,... -
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- Trefoil Factor 1 Suppresses Epithelial-mesenchymal Transition through Inhibition of TGF-beta Signaling in Gastric Cancer Cells
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Lee DY, Song MY, Kim EH
- KMID: 2517365
- J Cancer Prev.
- 2021 Jun;26(2):137-144.
- doi: 10.15430/JCP.2021.26.2.137
Gastric cancer is a malignancy with high incidence and mortality worldwide. In gastric cancer, epithelial-mesenchymal transition (EMT) and metastasis further increase the mortality rate. Trefoil factor 1 (TFF1) has been... -
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- Transforming growth factor-beta and liver injury in an arginine vasopressin-induced pregnant rat model
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Govender N, Ramdin S, Reddy R, Naicker T
- KMID: 2516562
- Clin Exp Reprod Med.
- 2021 Jun;48(2):124-131.
- doi: 10.5653/cerm.2020.04035
Objective: Approximately 30% of preeclamptic pregnancies exhibit abnormal liver function tests. We assessed liver injury-associated enzyme levels and circulating transforming growth factor beta (TGF-β) levels in an arginine vasopressin (AVP)-induced... -
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- TGF-β1 role in uterine leiomyoma and endometrial polyp: an insight to drug-based treatment instead of surgical techniques
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Faraji A, Shamsadinimoghadam R, Jahromi MA, Namazi N
- KMID: 2511571
- Obstet Gynecol Sci.
- 2021 Jan;64(1):107-113.
- doi: 10.5468/ogs.20191
Objective Considering the high prevalence of leiomyoma and endometrial polyps, investigating the contributing factors and determining the pathophysiology of these lesions are essential. Target therapy is now an acceptable method... -
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- Therapeutic potential of targeting kinase inhibition in patients with idiopathic pulmonary fibrosis
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Kim S, Lim JH, Woo CH
- KMID: 2508171
- Yeungnam Univ J Med.
- 2020 Oct;37(4):269-276.
- doi: 10.12701/yujm.2020.00458
Fibrosis is characterized by excessive accumulation of extracellular matrix components. The fibrotic process ultimately leads to organ dysfunction and failure in chronic inflammatory and metabolic diseases such as pulmonary fibrosis,... -
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- Vactosertib, a Novel, Orally Bioavailable Activin Receptor-Like Kinase 5 Inhibitor, Promotes Regression of Fibrotic Plaques in a Rat Model of Peyronie’s Disease
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Song KM, Chung DY, Choi MJ, Ghatak K, Nhat Minh N, Limanjaya A, Kwon MH, Ock J, Yin GN, Kim DK, Ryu JK, Suh JK
- KMID: 2506420
- World J Mens Health.
- 2020 Oct;38(4):552-563.
- doi: 10.5534/wjmh.190071
Purpose: To examine the therapeutic effect of Vactosertib, a small molecule inhibitor of transforming growth factor-β (TGF-β) type I receptor (activin receptor-like kinase-5, ALK5), in an experimental model of Peyronie’s... -
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- Irisin Regulates the Functions of Hepatic Stellate Cells
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Dong HN, Park SY, Le CT, Choi DH, Cho EH
- KMID: 2508015
- Endocrinol Metab.
- 2020 Sep;35(3):647-655.
- doi: 10.3803/EnM.2020.658
Background: Hepatic stellate cells (HSCs) are known to play a fundamental role in the progression of liver fibrosis. Once HSCs are activated, they are involved in proliferation, migration, and contractility... -
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- Peroxisome Proliferator-Activated Receptor Gamma Agonist Attenuates Liver Fibrosis by Several Fibrogenic Pathways in an Animal Model of Cholestatic Fibrosis
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Alatas FS, Matsuura T, Pudjiadi AH, Wijaya S, Taguchi T
- KMID: 2504160
- Pediatr Gastroenterol Hepatol Nutr.
- 2020 Jul;23(4):346-355.
- doi: 10.5223/pghn.2020.23.4.346
Purpose: Peroxisome proliferator-activated receptor gamma (PPAR-γ) has a key role in hepatic fibrogenesis by virtue of its effect on the hepatic stellate cells (HSCs). Although many studies have shown that... -
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- Eupatilin treatment inhibits transforming growth factor beta-induced endometrial fibrosis in vitro
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Lee CJ, Hong SH, Yoon MJ, Lee KA, Choi DH, Kwon H, Ko JJ, Koo HS, Kang YJ
- KMID: 2502744
- Clin Exp Reprod Med.
- 2020 Jun;47(2):108-113.
- doi: 10.5653/cerm.2019.03475
Objective: Endometrial fibrosis, the primary pathological feature of intrauterine adhesion, may lead to disruption of endometrial tissue structure, menstrual abnormalities, infertility, and recurrent pregnancy loss. At present, no ideal therapeutic... -
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- A Case of Anti-programmed Cell Death Ligand 1 and Anti-transforming Growth Factor Beta Antibody-associated Keratoacanthoma
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Byun HJ, Choi Y, Park CS, Lim Y, Park S, Lee DY, Park JH
- KMID: 2502808
- Korean J Dermatol.
- 2020 Mar;58(3):204-206.
Keratoacanthomas (KAs) are epithelial skin tumors characterized by rapid growth and spontaneous regression, with histopathologic features similar to those of cutaneous squamous cell carcinoma (SCC). KA arising after the use... -
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- Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
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Kim MJ, Kim NY, Jung YA, Lee S, Jung GS, Kim JG, Lee IK, Lee S, Choi YK, Park KG
- KMID: 2470966
- Diabetes Metab J.
- 2020 Feb;44(1):186-192.
- doi: 10.4093/dmj.2018.0271
Renal fibrosis is considered to be the final common outcome of chronic kidney disease. Dipeptidyl peptidase-4 (DPP-4) inhibitors have demonstrated protective effects against diabetic kidney disease. However, the anti-fibrotic effect... -
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- Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT
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Lin S, Yu L, Ni Y, He L, Weng X, Lu X, Zhang C
- KMID: 2470964
- Diabetes Metab J.
- 2020 Feb;44(1):158-172.
- doi: 10.4093/dmj.2018.0235
BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is required for renal fibrosis, which is a characteristic of diabetic nephropathy (DN). Our previous study demonstrated that fibroblast growth factor 21 (FGF21) prevented DN associated... -
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The Influence of Family History on Stage and Survival of Gastric Cancer According to the
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Kim HJ, Kwon M, Kim N, Lee JB, Won S
- KMID: 2508715
- Gut Liver.
- 2020 Jan;14(1):79-88.
- doi: 10.5009/gnl18471
Background/Aims: The survival rate of gastric cancer (GC) is known to be higher in patients with a family history (FH) of GC. There is an association between a polymorphism in... -
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- Clinicopathological Significance of SMAD4 Expression in Breast Cancer
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Woo JS, Chung MS, Paik SS
- KMID: 2470603
- J Breast Dis.
- 2019 Dec;7(2):52-58.
- doi: 10.14449/jbd.2019.7.2.52
PURPOSE: SMAD4 is a member of the SMAD family and acts as a central mediator of transforming growth factor beta signaling. Little is known about SMAD4 expression and its prognostic... -
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- Parthenolide inhibits transforming growth factor β1-induced epithelial-mesenchymal transition in colorectal cancer cells
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Zhu SM, Park YR, Seo SY, Kim IH, Lee ST, Kim SW
- KMID: 2465818
- Intest Res.
- 2019 Oct;17(4):527-536.
- doi: 10.5217/ir.2019.00031
BACKGROUND/AIMS: Transforming growth factor-β1 (TGF-β1) induction of epithelial-mesenchymal transition (EMT) is one of the mechanisms by which colorectal cancer (CRC) cells acquire migratory and invasive capacities, and subsequently metastasize. Parthenolide... -
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- Shen-Kang protects against tacrolimus-induced renal injury
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Zhang LY, Jin J, Luo K, Piao SG, Zheng HL, Jin JZ, Lim SW, Choi BS, Yang CW, Li C
- KMID: 2457031
- Korean J Intern Med.
- 2019 Sep;34(5):1078-1090.
- doi: 10.3904/kjim.2017.276
BACKGROUND/AIMS: Evidence suggests that Shen-Kang (SK), a traditional Chinese herbal medicine, protects against various types of renal injury. In this study, we evaluated whether SK treatment confers renoprotection in a... -
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- Increased CD68/TGFβ Co-expressing Microglia/Macrophages after Transient Middle Cerebral Artery Occlusion in Rhesus Monkeys
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Yeo HG, Hong JJ, Lee Y, Yi KS, Jeon CY, Park J, Won J, Seo J, Ahn YJ, Kim K, Baek SH, Hwang EH, Kim G, Jin YB, Jeong KJ, Koo BS, Kang P, Lim KS, Kim SU, Huh JW, Kim YH, Son Y, Kim JS, Choi CH, Cha SH, Lee SR
- KMID: 2458544
- Exp Neurobiol.
- 2019 Aug;28(4):458-473.
- doi: 10.5607/en.2019.28.4.458
The function of microglia/macrophages after ischemic stroke is poorly understood. This study examines the role of microglia/macrophages in the focal infarct area after transient middle cerebral artery occlusion (MCAO) in... -
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