- Biological Safety Test of Seoultype Keratoprosthesis
-
Chung TY, Choi SY, Kim MK, Wee WR, Lee JH
- KMID: 2126069
- J Korean Ophthalmol Soc.
- 2004 Apr;45(4):643-654.
PURPOSE: To perform biological safety test of the Seoul-type keratoprosthesis (SKpro) according to the international standards. METHODS: Mouse fibroblasts were used to assess the cellular toxicity, and albino rabbits were... -
- CITED
-
- Close
- SHARE
-
- Close
- Acute toxicity of benzalkonium chloride in Balb/c mice following intratracheal instillation and oral administration
-
Lee H, Park K
- KMID: 2470821
- Environ Anal Health Toxicol.
- 2019 Sep;34(3):e2019009.
- doi: 10.5620/eaht.e2019009
Benzalkonium chloride is a cationic surfactant widely used as a disinfectant, preservative, and sanitizer in many public places as well as domestically. The purpose of this study is to compare... -
- CITED
-
- Close
- SHARE
-
- Close
- Toxicity Assessment of Titanium (IV) Oxide Nanoparticles Using Daphnia magna (Water Flea)
-
Bang SH, Le TH, Lee SK, Kim P, Kim JS, Min J
- KMID: 2380152
- Environ Health Toxicol.
- 2011 ;26(1):e2011002.
OBJECTIVES: Titanium dioxide (TiO2), a common nanoparticle widely used in industrial production, is one of nano-sized materials. The purpose of this study was to determine the acute and chronic toxicity... -
- CITED
-
- Close
- SHARE
-
- Close
- Cellular Toxicity of Surfactants Used as Herbicide Additives
-
Song HY, Kim YH, Seok SJ, Gil HW, Yang JO, Lee EY, Hong SY
- KMID: 1792971
- J Korean Med Sci.
- 2012 Jan;27(1):3-9.
- doi: 10.3346/jkms.2012.27.1.3
The cellular toxicities of surfactants, a solvent, and an antifreeze that are included in herbicide formulations were assessed by measuring their effects on membrane integrity, metabolic activity, mitochondrial activity, and... -
- CITED
-
- Close
- SHARE
-
- Close
- Act on the Registration and Evaluation of Chemicals (K-REACH) and replacement, reduction or refinement best practices
-
Ha S, Seidle T, Lim KM
- KMID: 2469680
- Environ Health Toxicol.
- 2016 ;31(1):e2016026.
- doi: 10.5620/eht.e2016026
OBJECTIVES: Korea's Act on the Registration and Evaluation of Chemicals (K-REACH) was enacted for the protection of human health and the environment in 2015. Considering that about 2000 new substances... -
- CITED
-
- Close
- SHARE
-
- Close
- Aquatic Toxicity Assessment of Phosphate Compounds
-
Kim E, Yoo S, Ro HY, Han HJ, Baek YW, Eom IC, Kim HM, Kim P, Choi K
- KMID: 2380114
- Environ Health Toxicol.
- 2013 ;28(1):e2013002.
OBJECTIVES: Tricalcium phosphate and calcium hydrogenorthophosphate are high production volume chemicals, mainly used as foodstuff additives, pharmaceuticals, lubricants, synthetic resin, and disinfectants. Phosphate has the potential to cause increased algal... -
- CITED
-
- Close
- SHARE
-
- Close
- Screening of toxic potential of graphene family nanomaterials using in vitro and alternative in vivo toxicity testing systems
-
Chatterjee N, Yang JS, Park K, Oh SM, Park J, Choi J
- KMID: 2380083
- Environ Health Toxicol.
- 2015 ;30(1):e2015007.
- doi: 10.5620/eht.e2015007
OBJECTIVES: The widely promising applications of graphene nanomaterials raise considerable concerns regarding their environmental and human health risk assessment. The aim of the current study was to evaluate the toxicity... -
- CITED
-
- Close
- SHARE
-
- Close
- Toxicity of Polylactic Acid Polymer in the Treatment of Paranasal Sinusitis
-
Min YG, Kim YK, Jeon SY, Rha KS, Jeong SY
- KMID: 2297746
- J Rhinol.
- 1997 Nov;4(2):104-110.
The authors, after inducing acute sinusitis in rabbits, compared cases where we opened the natural ostium and a general dose of administered antibiotics and cases where we opened the natural... -
- CITED
-
- Close
- SHARE
-
- Close
- Use of adverse outcome pathways in chemical toxicity testing: potential advantages and limitations
-
Jeong J, Choi J
- KMID: 2434027
- Environ Health Toxicol.
- 2018 Mar;33(1):e2018002.
- doi: 10.5620/eht.e2018002
Amid revolutionary changes in toxicity assessment brought about by increasing regulation of chemicals, adverse outcome pathways (AOPs) have emerged as a useful framework to assess adverse effect of chemicals using... -
- CITED
-
- Close
- SHARE
-
- Close
- Keratinocytic Vascular Endothelial Growth Factor as a Novel Biomarker for Pathological Skin Condition
-
Bae ON, Noh M, Chun YJ, Jeong TC
- KMID: 2380357
- Biomol Ther.
- 2015 Jan;23(1):12-18.
- doi: 10.4062/biomolther.2014.102
Skin is an emerging target tissue in pharmaceutical and cosmetic science. Safety assessment for dermal toxicity is a critical step for development of topically applicable pharmaceutical agents and ingredients in... -
- CITED
-
- Close
- SHARE
-
- Close
- Recent Advances for Enhancing Drug Metabolizing Functions of Hepatocyte-like Cells Derived from Human Pluripotent Stem Cells
-
Han J, Kim JH
- KMID: 2129472
- Hanyang Med Rev.
- 2015 Nov;35(4):196-206.
- doi: 10.7599/hmr.2015.35.4.196
Hepatocyte-like cells (HLCs) derived from human pluripotent stem cells are a promising cell source for drug screening and toxicity tests. Thus, various hepatic differentiating protocols have been developed, leading to... -
- CITED
-
- Close
- SHARE
-
- Close
- Single- and repeated-dose toxicities of aloe fermentation products in rats
-
Cho JH, Kim HK, Baik SO, Choi SY, Lee JY
- KMID: 1850051
- Lab Anim Res.
- 2011 Sep;27(3):235-244.
- doi: 10.5625/lar.2011.27.3.235
In this study, aloe fermentation products were derived from mycelia from 3 mushrooms: Ganoderma lucidum (AG), Hericium erinaceum (AH), and Phellinus linteus (AP). Levels of aloin A and B increased... -
- CITED
-
- Close
- SHARE
-
- Close
- Single-Dose Oral Toxicity of Fermented Scutellariae Radix Extract in Rats and Dogs
-
Kim MS, Ham SH, Kim JH, Shin JE, Oh J, Kim TW, Yun HI, Lim JH, Jang BS, Cho JH
- KMID: 1432310
- Toxicol Res.
- 2012 Dec;28(4):263-268.
The aim of this study was to investigate the acute oral toxicity of fermented Scutellariae Radix (JKTMHGu-100) in rats and dogs. JKTM-HGu-100 was orally administered at a dose of 2,000... -
- CITED
-
- Close
- SHARE
-
- Close
- Maintaining the Constant Exposure Condition for an Acute Caenorhabditis elegans Mortality Test Using Passive Dosing
-
Kwon HC, Roh JY, Lim D, Choi J, Kwon JH
- KMID: 2380165
- Environ Health Toxicol.
- 2011 ;26(1):e2011015.
OBJECTIVES: Maintaining the constant exposure to hydrophobic organic compouds in acute toxicity tests is one of the most difficult issues in the evaluation of their toxicity and corresponding risks. Passive... -
- CITED
-
- Close
- SHARE
-
- Close
- Insecticidal Activity of Ethyl Acetate Extracts from Culture Filtrates of Mangrove Fungal Endophytes
-
Abraham S, Basukriadi A, Pawiroharsono S, Sjamsuridzal W
- KMID: 2312805
- Mycobiology.
- 2015 Jun;43(2):137-149.
- doi: 10.5941/MYCO.2015.43.2.137
In the search for novel potent fungi-derived bioactive compounds for bioinsecticide applications, crude ethyl acetate culture filtrate extracts from 110 mangrove fungal endophytes were screened for their toxicity. Toxicity tests... -
- CITED
-
- Close
- SHARE
-
- Close
- Two-Week Repeated Dose Toxicity of Atractylodis Rhizoma Alba in F344 Rats
-
Han HY, Yang YS, Kim SN, Han SC, Lee JH, Jeong JY, Roh HS, Seok JH, Lee JS, Kim JA, Min BS
- KMID: 2355143
- Nat Prod Sci.
- 2016 Sep;22(3):180-186.
- doi: 10.20307/nps.2016.22.3.180
This research is to estimate the toxicity of Atractylodis Rhizoma Alba (ARA) in F344 rats and to find a dose level for the 13 weeks toxicity study. A hot water... -
- CITED
-
- Close
- SHARE
-
- Close
- Risk assessment of di(2-ethylhexyl) phthalate in the workplace
-
Kim HY
- KMID: 2469667
- Environ Health Toxicol.
- 2016 ;31(1):e2016011.
- doi: 10.5620/eht.e2016011
OBJECTIVES: A hazard assessment of di(2-ethylhexyl) phthalate (DEHP), a commonly used workplace chemical, was conducted in order to protect the occupational health of workers. A literature review, consisting of both... -
- CITED
-
- Close
- SHARE
-
- Close
- Guideline on safety evaluation of cell-based medicinal products for animal use
-
Ku HO, Yi H, Park YI, Jeon BS, Kang HG, Kim YS, Park BK
- KMID: 2454016
- J Vet Sci.
- 2019 Mar;20(2):e14.
- doi: 10.4142/jvs.2019.20.e14
With the increased use of cell therapy in the veterinary sector, there is a growing demand for the development of cell-based medicinal products and the determination of their safety. Currently,... -
- CITED
-
- Close
- SHARE
-
- Close
- Investigation of Filamentous Fungi Producing Safe, Functional Water-Soluble Pigments
-
Heo YM, Kim K, Kwon SL, Na J, Lee H, Jang S, Kim CH, Jung J, Kim JJ
- KMID: 2427108
- Mycobiology.
- 2018 Sep;46(3):269-277.
- doi: 10.1080/12298093.2018.1513114
The production of water-soluble pigments by fungal strains indigenous to South Korea was investigated to find those that are highly productive in submerged culture. Among 113 candidates, 34 strains that... -
- CITED
-
- Close
- SHARE
-
- Close
- Human Skin Safety Test of Green Tea Cell Extracts in Condition of Allergic Contact Dermatitis
-
Kim HK, Choi SY, Chang HK, Baek SY, Chung JO, Rha CS, Kim BJ, Kim MN
- KMID: 1432248
- Toxicol Res.
- 2012 Jun;28(2):113-116.
Various kinds of positive effects of green tea extracts had been studied for long time which included anti-inflammation, anti-aging, and cardiometabolic effects. Although topical steroid and non-steroidal calcineurin inhibitors may... -
- CITED
-
- Close
- SHARE
-
- Close
