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Current Concept and Future of the Management of Spinal Cord Injury: A Systematic Review

Choi I, Ha JG, Jeon SR

  • KMID: 2297781
  • J Korean Soc Traumatol.
  • 2013 Sep;26(3):63-73.
Spinal cord injury (SCI) is a serious condition associated with social and familial burden, as well as significant neurologic deficit. Despite the many advances in the treatment of spinal cord...
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Therapeutic Application of Neural Stem Cells for Neonatal Hypoxic-ischemic Brain Injury

Park KI, Goo K, Jung K, Kim M, Kim IS, Yun S, Lee IS, Shin JE, Yu HY, Eun HS, Kim JE, Namgung R, Lee C

  • KMID: 2312947
  • Neonatal Med.
  • 2013 Aug;20(3):343-353.
Neural stem cells (NSCs) are characterized by a capacity for self-renewal, differentiation into multiple neural cell lineages, and migration toward damaged sites in the central nervous system (CNS). NSCs expanded...
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The Role of Large Animal Studies in Cardiac Regenerative Therapy Concise Review of Translational Stem Cell Research

Kwon SU, Yeung AC, Ikeno F

Animal models have long been developed for cardiovascular research. These animal models have been helpful in understanding disease, discovering potential therapeutics, and predicting efficacy. Despite many efforts, however, translational study...
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Human bone marrow-derived mesenchymal stem cell gene expression patterns vary with culture conditions

Lee MW, Kim DS, Yoo KH, Kim HR, Jang IK, Lee JH, Kim SY, Son MH, Lee SH, Jung HL, Sung KW, Koo HH

BACKGROUND: Because of the heterogeneity of human mesenchymal stem cells (MSCs), methods for cell expansion in culture and the effects on gene expression are critical factors that need to be...
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Cardiovascular repair with bone marrow-derived cells

Kim WS, Lee S, Yoon YS

While bone marrow (BM)-derived cells have been comprehensively studied for their propitious pre-clinical results, clinical trials have shown controversial outcomes. Unlike previously acknowledged, more recent studies have now confirmed that...
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Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells

Han JW, Sin MY, Yoon YS

Diabetic neuropathy (DN) is the most common and disabling complication of diabetes that may lead to foot ulcers and limb amputations. Despite widespread awareness of DN, the only effective treatments...
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Bone regeneration of mouse critical-sized calvarial defects with human mesenchymal stem cells in scaffold

Im JY, Min WK, You C, Kim HO, Jin HK, Bae JS

Combination of tissue engineering and cell therapy represents a promising approach for bone regeneration. Human mesenchymal stem cells (hMSCs) have properties that include low immunogenicity, high proliferation rate, and multi-differentiation...
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A brief overview of cell therapy and its product

Kim I

  • KMID: 2328618
  • J Korean Assoc Oral Maxillofac Surg.
  • 2013 Oct;39(5):201-202.
No abstract available.
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Stem Cell Implants for Cancer Therapy: TRAIL-Expressing Mesenchymal Stem Cells Target Cancer Cells In Situ

Reagan MR, Seib FP, McMillin D, Sage EK, Mitsiades , Janes SM, Ghobrial I, Kaplan DL

PURPOSE: Tumor-specific delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), an apoptosis-inducing peptide, at effective doses remains challenging. Herein we demonstrate the utility of a scaffold-based delivery system for sustained...
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The Past, Present, and Future of Adoptive T Cell Therapy

Choi D, Kim TG, Sung YC

  • KMID: 2424208
  • Immune Netw.
  • 2012 Aug;12(4):139-147.
Although adoptive T cell therapy (ACT) has become a promising immunotherapeutic regime for cancer treatment, its effectiveness has been hindered by several inherent shortcomings regarding safety and efficacy. During the...
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Strategy for Maximizing Therapeutic Efficacy of Adult Stem Cells

Koh SH

Stem cells have been suggested for the treatment of intractable neurological diseases. In spite of numerous clinical trials using autologous mesenchymal stem cells (MSCs), unfortunately, clinical efficacy has not yet...
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Clinical Applications of Neural Stem Cells for the Treatment of Peripheral Neuropathy

Park JM, Choi BO

Extraordinary advances in stem cell research have initiated an era of hope for strategies to treat intractable human diseases. Personalized regenerative treatment using stem cells is expected to accelerate continuous...
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Treatment Strategy for Parkinsonian Diseases Through Mesenchymal Stem Cells

Park HJ, Lee PH

Parkinsonian diseases including Parkinson's disease (PD) and multiple system atrophy (MSA) are neurodegenerative diseases representative of alpha-synucleinopathies characterized pathologically by alpha-synuclein-abundant Lewy bodies and glial cytoplasmic inclusions, respectively. Cell therapy...
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Application of Regulatory T Cells in Transplantation Field

Kim YH, Kim HJ, Kim JS, Park CG

  • KMID: 2324213
  • J Korean Soc Transplant.
  • 2012 Jun;26(2):74-82.
The development of immunosuppressant treatments has enabled remarkable progress in the tissue and organ transplantation field by helping to prevent acute graft rejection. However, complications related to transplantation, such as...
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Treatment of Spinal Muscolar Atrophy with Intrathecal Mesenchymal Cells

Andolina M

  • KMID: 1426159
  • Int J Stem Cells.
  • 2012 May;5(1):73-75.
BACKGROUND AND OBJECTIVES: SMA1 is a genetic disease that leads to a progressive apoptosis of the second motoneuron and then to a complete paralysis. There are reports of efficacy of...
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New Techniques for Treating an Anal Fistula

Song KH

Surgery for an anal fistula may result in recurrence or impairment of continence. The ideal treatment for an anal fistula should be associated with low recurrence rates, minimal incontinence and...
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Treatment of Duchenne Muscular Dystrophy: A Comprehensive Review

Park HJ, Choi YC

  • KMID: 2191517
  • J Korean Neurol Assoc.
  • 2012 Nov;30(4):257-266.
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder due to the loss of dystrophin in muscle fiber. The deficiency of dystrophin produces severe progressive muscle degeneration which leads to...
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Cell-Assisted Lipotransfer for the Treatment of Parry-Romberg Syndrome

Castro-Govea Y, De La Garza-Pineda O, Lara-Arias J, Chacon-Martinez H, Mecott-Rivera G, Salazar-Lozano A, Valdes-Flores E

Progressive facial hemiatrophy, also known as Parry-Romberg syndrome, is a progressive and self-limited deformation of the subcutaneous tissue volume on one side of the face that creates craniofacial asymmetry. We...
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Possibility of Undifferentiated Human Thigh Adipose Stem Cells Differentiating into Functional Hepatocytes

Lee JH, Lee KH, Kim MH, Kim JP, Lee SJ, Yoon J

BACKGROUND: This study aimed to investigate the possibility of isolating mesenchymal stem cells (MSCs) from human thigh adipose tissue and the ability of human thigh adipose stem cells (HTASCs) to...
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Neuronal Differentiation of a Human Induced Pluripotent Stem Cell Line (FS-1) Derived from Newborn Foreskin Fibroblasts

Kwon J, Lee N, Jeon I, Lee HJ, Do JT, Lee DR, Oh SH, Shin DA, Kim A, Song J

  • KMID: 1735408
  • Int J Stem Cells.
  • 2012 Nov;5(2):140-145.
Isolation of induced pluripotent stem cells (iPSCs) from fully differentiated somatic cells has revolutionized existing concepts of cell differentiation and stem cells. Importantly, iPSCs generated from somatic cells of patients...
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