- In-house Manual Construction of High-Density and High-Quality Tissue Microarrays by Using Homemade Recipient Agarose-Paraffin Blocks
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Kim KH, Choi SJ, Choi YI, Kim L, Park IS, Han JY, Kim JM, Chu YC
- KMID: 2277440
- Korean J Pathol.
- 2013 Jun;47(3):238-244.
BACKGROUND: Self-made tissue punches can be effectively used to punch holes in blank recipient paraffin blocks and extract tissue cores from the donor paraffin blocks for the low-cost construction of... -
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- Tissue Microarray Analysis of the Expression of p53, c-kit and CD34 in Sarcomas
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Yoo J, Park KS, Kang SJ, Kang CS
- KMID: 2275470
- Korean J Pathol.
- 2004 Aug;38(4):221-227.
BACKGROUND: Our objectives in this study were to (1) evaluate the possible role of p53, c-kit and CD34 proteins in sarcomas and to determine their potential relationship; (2) use a... -
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- Gastric biomarker study using proteomic method
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Jeong SH, Lee YJ, Soon-Chan , Ha WS
- KMID: 2360697
- Korean J Clin Oncol.
- 2016 Jun;12(1):7-12.
- doi: 10.14216/kjco.16002
Biomarker is defined as biological variables that correlate with biologic outcome. This review will discuss investigations into gastric cancer (GC) biomarkers by proteomic analysis. Proteomic analysis consists of 3 steps.... -
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- Construction of High-Density Tissue Microarrays at Low Cost by Using Self-Made Manual Microarray Kits and Recipient Paraffin Blocks
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Choi CH, Kim KH, Song JY, Choi SJ, Kim L, Park IS, Han JY, Kim JM, Chu YC
- KMID: 2012060
- Korean J Pathol.
- 2012 Dec;46(6):562-568.
BACKGROUND: Advances of tissue microarray (TMA) technology have enabled simultaneous in situ analysis of biomarker expression in a large number of archived pathology specimens. However, the relatively high cost of... -
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- Prognostic Implication of Semi-quantitative Immunohistochemical Assessment of CD20 Expression in Diffuse Large B-Cell Lymphoma
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Choi CH, Park YH, Lim JH, Choi SJ, Kim L, Park IS, Han JY, Kim JM, Chu YC
- KMID: 2211376
- J Pathol Transl Med.
- 2016 Mar;50(2):96-103.
- doi: 10.4132/jptm.2016.01.12
BACKGROUND: Immunohistochemical demonstration of CD20 in diffuse large B-cell lymphoma (DLBCL) is prerequisite not only for the diagnosis but also for assigning patients to rituximab-containing chemotherapy. However, little is known... -
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- Prognostic and Clinicopathological Significance of Transducer-Like Enhancer of Split 1 Expression in Gastric Cancer
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Lee JH, Son MW, Kim KJ, Oh MH, Cho H, Lee HJ, Jang SH, Lee MS
- KMID: 2372549
- J Gastric Cancer.
- 2016 Mar;16(1):21-27.
- doi: 10.5230/jgc.2016.16.1.21
PURPOSE: Transducer-like enhancer of split 1 (TLE1) is a member of the Groucho/TLE family of transcriptional co-repressors that regulate the transcriptional activity of numerous genes. TLE1 is involved in the... -
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- Gene Expression Profiles of Uterine Normal Myometrium and Leiomyoma and Their Estrogen Responsiveness In Vitro
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Lee EJ, Bajracharya P, Lee DM, Cho KH, Kim KJ, Bae YK, Kim MJ, Lee KH, Kim HJ, Song GH, Chun SS, Choi I
- KMID: 1837531
- Korean J Pathol.
- 2010 Jun;44(3):272-283.
BACKGROUND: Uterine leiomyomas are common benign smooth muscle tumors among the reproductive aged-women. The research has been aimed to identify the differentially expressed genes between normal myometrium and leiomyoma and... -
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- High Notch1 Expression Correlates with Tumor Stage and Size in Clear Cell Renal Cell Carcinoma
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Lee JN, Chun SY, Lee HJ, Ha YS, Kim HT, Yoo ES, Kwon TG, Kim TH
- KMID: 2368946
- Korean J Urol Oncol.
- 2016 Dec;14(3):130-137.
- doi: 10.22465/kjuo.2016.14.3.130
PURPOSE: Although the influence of Notch signaling on several types of malignancies has been studied, the role of Notch signaling in clear cell renal cell carcinoma (ccRCC) remains unclear. In... -
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- The Relationship between Prognostic Factors and the Expression Pattern of Fascin and E-cadherin in Renal Cell Carcinoma
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Kang SH, Chae SW, Lee KB, Kim DH, Kim MK, Sohn JH
- KMID: 2073793
- Korean J Pathol.
- 2009 Apr;43(2):139-144.
BACKGROUND: Fascin is associated with motility in various transformed cells. Overexpression of fascin is known to aid in the progression of some cancers and is associated with a poor prognosis.... -
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- Prognostic Significance of Tissue Leptin Expression in Colorectal Cancer Patients
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Jeong WK, Baek SK, Kim MK, Kwon SY, Kim HS
- KMID: 2150962
- Ann Coloproctol.
- 2015 Dec;31(6):222-227.
- doi: 10.3393/ac.2015.31.6.222
PURPOSE: Leptin is encoded by the ob gene and is involved in the control of food intake and energy expenditure. Recent studies have implicated leptin expression to be an indicator... -
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- The Usefulness of CDX-2 for Differentiating Primary and Metastatic Ovarian Carcinoma: An Immunohistochemical Study Using a Tissue Microarray
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Kim MJ
- KMID: 1712747
- J Korean Med Sci.
- 2005 Aug;20(4):643-648.
- doi: 10.3346/jkms.2005.20.4.643
Distinguishing primary ovarian carcinoma from metastatic carcinoma to the ovary is often difficult by histologic examination alone. Recently an immunohistochemical marker CDX-2 was found to be of considerable diagnostic value... -
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- An Immunohistochemical Study on the Expression of SUMO-2/3 in the Colorectal Carcinoma
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Ham JH, Park J, Park DS, Lee SS, Yang SH, Jeong D
- KMID: 2317655
- Soonchunhyang Med Sci.
- 2012 Dec;18(2):95-101.
OBJECTIVE: The incidence of colorectal carcinomas continues to rise in Korea due to the westernized life style. However, the precise colorectal carcinogenic mechanisms remain to be elucidated. The protein products... -
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- Aquaporin 1 Is an Independent Marker of Poor Prognosis in Lung Adenocarcinoma
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Yun S, Sun PL, Jin Y, Kim H, Park E, Park SY, Lee K, Lee K, Chung JH
- KMID: 2345546
- J Pathol Transl Med.
- 2016 Jul;50(4):251-257.
- doi: 10.4132/jptm.2016.03.30
BACKGROUND: Aquaporin 1 (AQP1) overexpression has been shown to be associated with uncontrolled cell replication, invasion, migration, and tumor metastasis. We aimed to evaluate AQP1 expression in lung adenocarcinomas and... -
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- Validation of Tissue Microarrays for the Study of Immunosuppressive Agent-induced Nephrotoxicity
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Lim BJ, Kim JH, Jeong HJ
- KMID: 1495868
- J Korean Soc Transplant.
- 2013 Sep;27(3):114-120.
- doi: 10.4285/jkstn.2013.27.3.114
BACKGROUND: Tissue microarray analysis (TMA) is a high-throughput method for histologic evaluation, immunohistochemistry, and in situ hybridization using paraffin embedded tissue. Despite its high efficiency as an experimental tool, TMA... -
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- Expression of Sarcosine Metabolism-Related Proteins in Invasive Lobular Carcinoma: Comparison to Invasive Ductal Carcinoma
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Cha YJ, Jung WH, Cho NH, Koo JS
- KMID: 2450331
- Yonsei Med J.
- 2015 May;56(3):598-607.
- doi: 10.3349/ymj.2015.56.3.598
PURPOSE: The aims of this study were to compare the expression of sarcosine metabolism-related proteins between invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) and to determine the implications... -
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- Forkhead Transcription Factor FOXO1 Inhibits Angiogenesis in Gastric Cancer in Relation to SIRT1
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Kim SY, Ko YS, Park J, Choi Y, Park JW, Kim Y, Pyo JS, Yoo YB, Lee JS, Lee BL
- KMID: 2152293
- Cancer Res Treat.
- 2016 Jan;48(1):345-354.
- doi: 10.4143/crt.2014.247
PURPOSE: We previously reported that forkhead transcription factors of the O class 1 (FOXO1) expression in gastric cancer (GC) was associated with angiogenesis-related molecules. However, there is little experimental evidence... -
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- Prognostic value of programmed death-ligand 1 (PD-L1) expression in ovarian clear cell carcinoma
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Zhu J, Wen H, Bi R, Wu Y, Wu X
- KMID: 2413203
- J Gynecol Oncol.
- 2017 Nov;28(6):e77.
- doi: 10.3802/jgo.2017.28.e77
OBJECTIVE: Programmed death-ligand 1 (PD-L1) was expressed in various tumors and antibodies targeting its receptor programmed cell death-1 (PD-1) are emerging cancer therapeutics. This study was designed to evaluate the... -
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- nm23-H1 Protein Expression and Gene Mutation in 150 Patients with Non-Hodgkin's Lymphomas
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Lee JH, Cho SJ, Zhang X, Zheng Z, Lee ES, Kim A, Kim YS, Chae YS, Kim I
- KMID: 2157815
- J Korean Med Sci.
- 2006 Aug;21(4):645-651.
- doi: 10.3346/jkms.2006.21.4.645
The metastasis-suppressing role of the nm23 gene in the metastatic spread of malignant tumor is still debated. We examined the nm23-H1 protein expression and gene mutation in non-Hodgkin's lymphomas to... -
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- Integrative Analysis of Microarray Data to Reveal Regulation Patterns in the Pathogenesis of Hepatocellular Carcinoma
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Chen J, Qian Z, Li F, Li J, Lu Y
- KMID: 2412162
- Gut Liver.
- 2017 Jan;11(1):112-120.
- doi: 10.5009/gnl16063
BACKGROUND/AIMS: The integration of multiple profiling data and the construction of a transcriptional regulatory network may provide additional insights into the molecular mechanisms of hepatocellular carcinoma (HCC). The present study... -
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- Expression of Peroxisome Proliferato Activated Receptor gamma in Prostatic Adenocarcinoma
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Park HK, Kim H, Kim HG, Cho YM, Jung WY, Han HS, Hwang TS, Kwon GY, Lim SD
- KMID: 2155464
- J Korean Med Sci.
- 2015 May;30(5):533-541.
- doi: 10.3346/jkms.2015.30.5.533
Peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor has been investigated as the target for cancer treatment as well as metabolic disorders. Recent studies have demonstrated that PPAR-gamma ligands... -
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