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8 results

Merlin Represses Ras-Induced Cyclin D1 Transcription through the Cyclic AMP-Responsive Element

Kwak NJ, Kim H, Choi BH, Kim YH, Rha HK, Lee KH

  • Korean J Physiol Pharmacol.
  • 2003 Oct;7(5):289-293.
Mutations in the NF2 tumor suppressor gene cause neurofibromatosis type 2, an autosomal dominant inherited syndrome predisposed to the multiple tumors of the nervous system. Merlin, the NF2 gene product...
Inhibitory Effect of Esculetin on the Inducuble Nitric Oxide Synthase Expression in TNF-stimulated 3T3-L1 Adipocytes

Yang JY

  • Korean J Physiol Pharmacol.
  • 2003 Oct;7(5):283-287.
While nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) is beneficial for host survival, it is also detrimental to the host. Thus, regulation of iNOS gene expression may...
Expression Profiles of Immune-related Genes in Fluoxetine-treated Human Mononuclear Cells by cDNA Microarray

Lee HJ, Jin SY, Hong MS, Li GZ, Kim JW, Kim BS, Chung JH

  • Korean J Physiol Pharmacol.
  • 2003 Oct;7(5):279-282.
To investigate the effect of fluoxetine, one of selective serotonin reuptake inhibitors (SSRIs), on the immune system, human peripheral blood mononuclear cells (PBMC) were treated with fluoxetine (10 7 M)...
A Simple and Accurate Method for Determining Antioxidative Activity

Bae JW, Lee MH

  • Korean J Physiol Pharmacol.
  • 2003 Oct;7(5):275-278.
Antioxidative activity is an important factor in inhibiting oxidative stress. The usual methods for determining antioxidative activity are time-consuming and cumbersome. They are also indirect processes that use biological material...
The Substates with Mutants That Negatively Charged Aspartate in Position 172 Was Replaced with Positive Charge in Murine Inward Rectifier Potassium Channel (Murine Kir2.1)

So I, Ashmole I, Stanfield

  • Korean J Physiol Pharmacol.
  • 2003 Oct;7(5):267-273.
We have investigated the effect on inducing substate (s) of positively charged residues replaced in position 172 of the second transmembrane domain in murine inward rectifier potassium channels, formed by...
Prevention of Diabetes Using Adenoviral Mediated Hepatocyte Growth Factor Gene Transfer in Mice

Lee HJ, Kim HJ, Roh MS, Lee JI, Lee SW, Jung DS, Kim DK, Park MK

  • Korean J Physiol Pharmacol.
  • 2003 Oct;7(5):261-266.
Type 1 diabetes is an organ-specific autoimmune disease caused by the cytotoxic T cells-mediated destruction of the insulin-producing beta cells in the Langerhans pancreatic islets. Hepatocyte growth factor (HGF) is...
CD40 Activation Protects Dendritic Cells from Anticancer Drug-Induced Apoptosis

Jun JY, Joo HG

  • Korean J Physiol Pharmacol.
  • 2003 Oct;7(5):255-260.
Dendritic cells (DCs) play a critical role in various immune responses involving CD4 T cells and have been used to generate anti-tumor immunity. Chemotherapy induces severe side effects including immunosuppression...
Antagonists of NMDA Receptor, Calcium Channel and Protein Kinase C Potentiate Inhibitory Action of Morphine on Responses of Rat Dorsal Horn Neuron

Shin HK, Kim YS, Jun JH, Lee SE, Kim JH

  • Korean J Physiol Pharmacol.
  • 2003 Oct;7(5):251-254.
he present study was designed to examine whether the co-application of morphine with Ca2+ channel antagonist (Mn2+, verapamil), N-methyl-D-aspartate (NMDA) receptor antagonist (2-amino-5-phosphonopentanoic acid[AP5], Mg2+) or protein kinase C inhibitor...

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