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Upregulation of Renal Renin-Angiotensin System in Rats with Adriamycin-Induced Nephrosis

Kim SW, Lee JU, Han SW, Ryu JH, Oh YW, Kim NH, Choi KC, Kim HJ

  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):127-130.
The present study was aimed to investigate whether the adriamycin-induced nephrosis is associated with an altered regulation of local renin-angiotensin system (RAS) in the kidney. Rats were subjected to a...
Enhanced Expression of Aldosterone Synthase and Adrenomedullin in Left and Right Ventricular Hypertrophy in Rats

Lee JU, Lee S, Kim S, Lee WJ

  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):121-126.
The pathophysiological implications of aldosterone and adrenomedullin in the cardiac ventricular hypertrophy were examined. Male Sprague-Dawley rats were treated with deoxycorticosterone acetate (DOCA)-salt and monocrotaline (MCT) to selectively elicit left...
Increases in Effective Cleft Glutamate Concentration During Expression of LTP

Jung SH, Choi S

  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):113-120.
Long-term potentiation (LTP) at hippocampal CA3-CA1 synapses is often associated with increases in quantal size, traditionally attributed to enhanced availability or efficacy of postsynaptic glutamate receptors. However, augmented quantal size...
The Regulation of AP-1 DNA Binding Activity by Long-term Nicotine Stimulation in Bovine Adrenal Medullary Chromaffin Cells: Role of Second Messengers

Lee JK, Choi SS, Suh HW

  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):109-112.
The signal pathways involved in the regulation of AP-1 DNA binding activity in long-term nicotine stimulated bovine adrenal medullary chromaffin (BAMC) cells have not been well characterized. To understand the...
Changes in the Expressional Levels of Sarcoplasmic Reticulum Ca2+-regulatory Proteins in the Postnatal Developing Rat Heart

Lee EH, Park SS, Lee JS, Seo YJ, Kim YH, Kim HW

  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):101-108.
In the present study, the postnatal developmental changes in the expressional levels of cardiac sarcoplasmic reticulum (SR) Ca2+ regulatory proteins, i.e. Ca2+-ATPase, phospholamban, and Ca2+ release channel, were investigated. Both...
Increase of Intracellular Ca2+ Concentration Induced by Lysophosphatidylcholine in Murine Aortic Endothelial Cells

Zhu MH, Park SJ, Kim HJ, Yang DK, Suh SH, So I, Kim KW

  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):93-100.
Effects of oxidized low-density lipoprotein (ox-LDL), l-alpha-stearoyl-lysophosphatidylcholine (LPC), on intracellular Ca2+ concentration were examined in mouse endothelial cells by measuring intracellular Ca2+ concentration ([Ca2+]i) with fura 2-AM and reverse transcription-polymerase...
Effect of Ca2+-channel Blockers on Norepinephrine Release in the Rat Hippocampal Slice and Synaptosome

Kim SW, Jung KY, Choi BK

  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):87-92.
The aim of this study was to investigate the role of Ca2+-channel blockers in norepinephrine (NE) release from rat hippocampus. Slices and synaptosomes were incubated with [3H]-NE and the releases...
Correlation between mEPSC Amplitude and Rise Time upon the Blockade of AMPA Receptor Desensitization at Hippocampal Synapses

Jung SH, Choi S

  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):81-86.
Conventional views of synaptic transmission generally overlook the possibility of "postfusional- control" the regulation of the speed or completeness of transmitter release upon vesicular fusion. However, such regulation often occurs...
Noradrenergic Modulation of Spontaneous Inhibitory Postsynaptic Currents in the Hypothalamic Paraventricular Nucleus

Lee LH, Chong W, Lee K, Park JB, Ryu PD

  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):71-80.
Previous studies have suggested that brain stem noradrenergic inputs differentially modulate neurons in the paraventricular nucleus (PVN). Here, we compared the effects of norepinephrine (NE) on spontaneous GABAergic inhibitory postsynaptic...
Muscarine M2 Receptor-mediated Presynaptic Inhibition of GABAergic Transmission in Rat Meynert Neurons

Jang IS, Akaike N

  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):63-70.
Cholinergic modulation of GABAergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) by the activation of muscarine receptors was investigated in mechanically dissociated rat nucleus basalis of the Meynert neurons using the...

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