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Selective cytotoxicity of a novel platinum(II) coordination complex on human bladder cancer cell lines and normal kidney cells

Jung JC, Chung JH, Chang SG, Rho YS

  • Korean J Physiol Pharmacol.
  • 2000 Apr;4(2):159-167.
We have synthesized a novel platinum(II) coordination complex containing cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,2-dichloroethane (DCE) as a leaving group. In addition, nitrate was added to improve the water-solubility. A new...
Influence of staurosporine on catecholamine release evoked by cholinergic stimulation and membrane depolarization from the rat adrenal gland

Lim DY, Choi YS, Yang WH, Lee YK, Lim Y, Choi CH, Yu BS

  • Korean J Physiol Pharmacol.
  • 2000 Apr;4(2):149-158.
The present study was attempted to examine the effect of staurosporine (STS) on secretion of catecholamines (CA) evoked by cholinergic stimulation and membrane depolarization from the isolated perfused rat adrenal gland and to...
Increased expression of nitric oxide synthase coincides with reversal of renovascular hypertension

Paek YW, Park YH, Kim SW, Lee JU

  • Korean J Physiol Pharmacol.
  • 2000 Apr;4(2):143-147.
The present study was aimed at investigating whether there are changes in the expression of nitric oxide synthase (NOS) in relation with the unclipping-induced fall of blood pressure in two-kidney, one clip (2K1C)...
Effect of brain angiotensin II receptor antagonists and antisense oligonucleotide on drinking and renal renin in rats

Cho HK, Yang EK, Han HS, Lee WJ, Phillips M

  • Korean J Physiol Pharmacol.
  • 2000 Apr;4(2):137-142.
The physiological roles of brain angiotensin II in mediating water deprivation-induced drinking and in regulating renal renin release were assessed in male Sprague-Dawley rats. Specific AT1 receptor antagonists, losartan and SK 1080, and...
Effects of p-chlorophenylalanine on the synthesis of pancreatic amylase in rats

Kwon HY, Eum WS, Jang HW, Lee YL, Park HJ

  • Korean J Physiol Pharmacol.
  • 2000 Apr;4(2):129-135.
Previously, we have reported that p-chlorophenylalanine (PCPA), a serotonin depletor, profoundly increased pancreatic fluid and bicarbonate secretion but remarkably inhibited pancreatic amylase secretion in anesthetized rats. The present study was performed to verify the...
The role of lipid peroxidation and glutathione on the glycochenodeoxycholic acid-induced cell death in primary cultured rat hepatocytes

Chu SH, Park WM, Lee KE, Pae YS

  • Korean J Physiol Pharmacol.
  • 2000 Apr;4(2):121-127.
Intracellular accumulation of bile acids in the hepatocytes during cholestasis is thought to be pathogenic in cholestatic liver diseases. The objective of this study was to determine the role of lipid peroxidation and...
Regulation of the contraction induced by emptying of intracellular Ca2+ stores in cat gastric smooth muscle

Baek HJ, Sim SS, Rhie DJ, Yoon SH, Hahn SJ, Jo YH, Kim MS

  • Korean J Physiol Pharmacol.
  • 2000 Apr;4(2):113-120.
To investigate the mechanism of smooth muscle contraction induced by emptying of intracellular Ca2+ stores, we measured isometric contraction and 45Ca2+ influx. CaCl2 increased Ca2+ store emptying- induced contraction in dose-dependent manner, but...
Muscarinic receptor subtype controlling the carbachol-induced muscle contraction in guinea pig gastric antrum

Rhee JC, Uhm DY, Kang TM

  • Korean J Physiol Pharmacol.
  • 2000 Apr;4(2):105-111.
Stimulation of muscarinic receptors by carbachol (CCh) in the circular smooth muscle of the guinea pig gastric antrum causes muscle contraction. In the present study, muscarinic receptor subtype controlling the muscle contraction in...
Differential effects of nitric oxide synthase inhibitors in rats

Lee JH, Shin CY, Kang BS, Jeong JH, Choi KB, Min YS, Kim JH, Huh IH, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2000 Apr;4(2):99-104.
We investigated the action of NOS inhibitors on NOS in rats. Both of nitric oxide synthase inhibitors, NG-monomethyl-L-arginine (L-NMMA, 3 micrometer) or NG-nitro-L-arginine methylester (L-NAME, 30 micrometer), augmented phenylephrine (PE, 10-7 M)-induced contraction...
Combined trial of fish oil and exercise training prevents impairment in insulin action on glucose transport of skeletal muscle induced by high-fat diet in rats

Lee JH, Kim JY, Kim YW, Park SY, Youn WK, Jang EC, Park DI, Kim SJ, Kim EJ, Lee SK

  • Korean J Physiol Pharmacol.
  • 2000 Apr;4(2):91-97.
The purpose of the present study was to determine the preventive effects of combined interventional trial of fish oil treatment and exercise training on insulin resistance of skeletal muscle in high-fat fed rats....
The role of K+ channels on spontaneous action potential in rat clonal pituitary GH3 cell line

Rhim H, Baek HJ, Ho WK, Earm YE

  • Korean J Physiol Pharmacol.
  • 2000 Apr;4(2):81-90.
The types of K+ channel which determine the pattern of spontaneous action potential (SAP) were investigated using whole-cell variation of patch clamp techniques under current- and voltage-clamp recording conditions in rat clonal pituitary...

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