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Ethanol prevents from acetaminophen inducible hepatic necrosis by inhibiting its metabolic activation in mice

Lee SM, Cho TS, Cha YN

  • Korean J Physiol Pharmacol.
  • 1998 Apr;2(2):261-269.
Concomitant administration of a single acute dose of ethanol (4 g/kg) protected mice from the hepatocellular injury observed upon administration of a large dose of acetaminophen (400 mg/kg). This was evidenced by the...
Cromakalim blocks membrane phosphoinositide activated signals in the guinea pig lung mast cells stimulated with antigen-antibody reactions

Ro JY, Kim JY, Kim KH

  • Korean J Physiol Pharmacol.
  • 1998 Apr;2(2):251-260.
Cromakalim (BRL 34915), known as an airway smooth muscle relaxant, inhibited the releases of mediators in the antigen-induced mast cell activation. It has been suggested that cromakalim, in part, inhibited mediator releases by...
Study on the action by PAF on IL-1 modulation in alveolar macrophages: Involvement of endogenous arachidonate metabolites and intracellular Ca++ mobilization

Lee J, Kim WK, Hah JS

  • Korean J Physiol Pharmacol.
  • 1998 Apr;2(2):241-249.
Platelet-activating factor (PAF) enhanced interleukin-1 (IL-1) activity by the interaction with a specific receptor in rat alveolar macrophages. In this study, we investigated the role of endogenous arachidonate metabolites and intracellular calcium mobilization...
Inducible nitric oxide synthase mRNA expression and nitric oxide production in silica-induced acute inflammatory lung injury

Lee J

  • Korean J Physiol Pharmacol.
  • 1998 Apr;2(2):233-239.
Stimulated alveolar macrophages and neutrophils produce nitric oxide, a free radical by an inducible nitric oxide synthase (iNOS), which reacts with superoxide anion to form peroxynitrite, a more highly reactive toxic species. The...
Modulation of outward potassium currents by nitric oxide in longitudinal smooth muscle cells of guinea-pig ileum

Kwon SC, Rim SJ, Kang BS

  • Korean J Physiol Pharmacol.
  • 1998 Apr;2(2):225-232.
To investigate the possible involvement of outward potassium (K+) currents in nitric oxide-induced relaxation in intestinal smooth muscle, we used whole-cell patch clamp technique in freshly dispersed guinea-pig ileum longitudinal smooth muscle cells....
Electrolysis of physiological salt solution generates a factor that relaxes vascular smooth muscle

Song PO, Chang KC

  • Korean J Physiol Pharmacol.
  • 1998 Apr;2(2):217-223.
Oxygen-derived free radicals have been implicated in many important functions in the biological system. Electrical field stimulation (EFS) causes arterial relaxation in animal models. We found that EFS applied to neither muscle nor...
Hypoxia-induced EDNO release is further augmented by previous hypoxia and reoxygenation in rabbit aortic endothelium

Han JJ, Suh SH, Suh KP, Kim KW

  • Korean J Physiol Pharmacol.
  • 1998 Apr;2(2):209-216.
The present study was designed: (1) to determine whether or not hypoxia stimulates the release of endothelium-derived relaxing factors (EDRFs) from endothelial cells, and (2) to examine whether or not the hypoxia-induced EDRFs...
Inhibitory effects of ginseng saponins on c-fos mRNA expression and the proliferation of rat aortic vascular smooth muscle cells stimulated by angiotensin II

Choi W, Jung JY, Kim HS, Yun YP, Park JD, Ahn HY

  • Korean J Physiol Pharmacol.
  • 1998 Apr;2(2):201-207.
To evaluate the possibility that the ginseng saponins could be developed as an anti-arteriosclerotic agent, we examined the inhibitory effects of ginseng saponins (total saponin(TS), panaxatriol(PT), panaxadiol(PD)) on the expression of c-fos mRNA...
Contractile effects of hemoglobin-free human cerebrospinal fluid on isolated porcine cerebral arteries

Baik YH, Kang SY, Kook H, Chyung SK, Kook YJ, Kang SS

  • Korean J Physiol Pharmacol.
  • 1998 Apr;2(2):193-199.
To elucidate the mechanism involved in the cerebral vascular spasm following subarachnoid hemorrhage (SAH), the effects of the cerebrospinal fluid (CSF) obtained from the SAH patients on the resting tension and its influence...
A role of endogenous somatostatin in exocrine secretion induced by intrapancreatic cholinergic activation

Park HS, Park IS, Kwon HY, Lee YL, Park HJ

  • Korean J Physiol Pharmacol.
  • 1998 Apr;2(2):185-192.
A role of endogenous somatostatin in pancreatic exocrine secretion induced by intrapancreatic cholinergic activation was studied in the isolated rat pancreas perfused with modified Krebs-Henseleit solution. Intrapancreatic neurons were activated by electrical field...
Influence of glucocorticoids on cholinergic stimulation-induced catecholamine secretion from the rat adrenal medulla

Lim DY, Lee JJ, Gweon OS

  • Korean J Physiol Pharmacol.
  • 1998 Apr;2(2):173-184.
The present study was undertaken to examine the influence of glucocorticoids on the secretory responses of catecholamines (CA) evoked by acetylcholine (ACh), DMPP, McN-A-343, excess K+ and Bay-K-8644 from the isolated perfused rat...
External pH effects on delayed rectifier K+ currents of small dorsal root ganglion neuron of rat

Kim YH, Jung H, Lim IJ, Chung S, Bang HW

  • Korean J Physiol Pharmacol.
  • 1998 Apr;2(2):165-172.
Under certain pathophysiological conditions, such as inflammation and ischemia, the concentration of H+ ion in the tissue surrounding neurons is changed. Variations in H+ concentration are known to alter the conduction and/of the...
Comparison of somatostatin and morphine action on the responses of wide dynamic range cells in the dorsal horn to peripheral noxious mechanical and heat stimulation in cats

Jung SJ, Choi YI, Kim J

  • Korean J Physiol Pharmacol.
  • 1998 Apr;2(2):155-163.
The purpose of present study was to compare the effects of somatostatin (SOM) and morphine (Mor) on the responses of wide dynamic range (WDR) cells to peripheral noxious stimulation. Single neuronal activity...
Effect of K+-channel blockers on the muscarinic- and A|1-adenosine-receptor coupled regulation of electrically evoked acetylcholine release in the rat hippocampus

Yu BS, Kim DK, Choi BK

  • Korean J Physiol Pharmacol.
  • 1998 Apr;2(2):147-154.
It was attempted to clarify the participation of K+ channels in the post-receptor mechanisms of the muscarinic and A1-adenosine receptor-mediated control of acetylcholine (ACh) release in the present study. Slices from the rat...
Ca2+ signalling in endothelial cells: Role of ion channels

Nilius B, Viana F, Kamouchi M, Fasolato C, Eggermont , Droogmans

  • Korean J Physiol Pharmacol.
  • 1998 Apr;2(2):133-145.
Ca2+-signals in endothelial cells are determined by release from intracellular stores and entry through the plasma membrane. In this review, the nature of Ca2+ entry and mechanisms of its control are reviewed. The...

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