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Botulinum toxin type A enhances the inhibitory spontaneous postsynaptic currents on the substantia gelatinosa neurons of the subnucleus caudalis in immature mice

Jang SH, Park SJ, Lee CJ, Ahn DK, Han SK

Botulinum toxin type A (BoNT/A) has been used therapeutically for various conditions including dystonia, cerebral palsy, wrinkle, hyperhidrosis and pain control. The substantia gelatinosa (SG) neurons of the trigeminal subnucleus...
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Increased Tone of the Human Colon Muscle by Bisacodyl In Vitro

Min YW, Ko EJ, Kim JH, Lee JY, Kim HC, Lee WY, Rhee PL

  • KMID: 2413108
  • J Neurogastroenterol Motil.
  • 2018 Apr;24(2):317-323.
  • doi: 10.5056/jnm17063
BACKGROUND/AIMS: Although bisacodyl is a widely administered laxative, its underlying mechanism of action remains generally unknown. This study focuses on investigating the effects of bisacodyl on the human colon muscle...
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Korean red ginseng excitation of paraventricular nucleus neurons via non-N-methyl-D-aspartate glutamate receptor activation in mice

Shen Y, Bhattarai , Park SJ, Lee GS, Ryu PD, Han SK

It has been reported that Korean red ginseng (KRG), a valuable and important traditional medicine, has varied effects on the central nervous system, suggesting its activities are complicated. The paraventricular...
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Action of Mitochondrial Substrates on Neuronal Excitability in Rat Substantia Gelatinosa Neurons

Lee HI, Chun SW

Recent studies indicate that mitochondria are an important source of reactive oxygen species (ROS) in the spinal dorsal horn. In our previous study, application of malate, a mitochondrial electron transport...
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The Effect of Deoxycholic Acid on Secretion and Motility in the Rat and Guinea Pig Large Intestine

Kim NH, Park JH, Park JS, Joung YH

  • KMID: 2395430
  • J Neurogastroenterol Motil.
  • 2017 Oct;23(4):606-615.
  • doi: 10.5056/jnm16201
BACKGROUND/AIMS: Bile acid is an important luminal factor that affects gastrointestinal motility and secretion. We investigated the effect of bile acid on secretion in the proximal and distal rat colon...
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Slow Wave Activity and Modulations in Mouse Jejunum Myenteric Plexus In Situ

Cai Y, Tang H, Jiang F, Dong Z

  • KMID: 2367463
  • J Neurogastroenterol Motil.
  • 2017 Jan;23(1):117-123.
  • doi: 10.5056/jnm16012
BACKGROUND/AIMS: Myenteric plexus interstitial cells of Cajal (ICC-MY) are involved in the generation of gut pacemaker activity and neuronal communication. We performed patch clamp on ICC-MY in situ to observe...
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Nitrergic Pathway Is the Major Mechanism for the Effect of DA-9701 on the Rat Gastric Fundus Relaxation

Min YW, Ko EJ, Lee JY, Min BH, Lee JH, Kim JJ, Rhee PL

  • KMID: 2381190
  • J Neurogastroenterol Motil.
  • 2014 Jul;20(3):318-325.
BACKGROUND/AIMS: DA-9701 significantly improved gastric accommodation by increasing the postprandial gastric volume. In this study, we investigated how DA-9701 affects the rat gastric fundus relaxation. METHODS: Gastric fundus muscle strips (9...
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Characteristics of Diprophylline-Induced Bidirectional Modulation on Rat Jejunal Contractility

Liu FF, Chen DP, Xiong YJ, Lv BC, Lin Y

In this study, we propose that diprophylline exerts bidirectional modulation (BM) on the isolated rat jejunal segment depending on its contractile state. The results supported the hypothesis. Diprophylline (20 microM)...
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The Clinical Features and Prognostic Factors in Adults with Acute Etrodotoxin Poisoning Caused by Ingesting Puffer Fish

Jo YS, Chun BJ, Moon JM, Ryu HH, Jung YH, Lee SM, Song KH, Ryu JH

  • KMID: 2203541
  • J Korean Soc Clin Toxicol.
  • 2014 Dec;12(2):46-53.
PURPOSE: We conducted this study in order to determine clinical features and prognostic factors in adults with acute tetrodotoxin (TTX) poisoning caused by ingestion of puffer fish. METHODS: In this retrospective...
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A Case of Hemoperitoneum due to Spontaneous Rupture of Visceral Artery Aneurysm after Ingestion of Puffer Fish

Lee DW, Kim HK, Lee HJ, Hong JM, Kwon JY

Ingestion of puffer fish can cause intoxication, which produces a wide range of symptoms due to the presence of neurotoxins, such as tetrodotoxin, in puffer fish. Abdominal pain is just...
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Transient Diabetes Insipidus Associated with Tetrodotoxin Intoxication: A Case Report

Wi DH

  • KMID: 2333321
  • J Korean Soc Emerg Med.
  • 2013 Apr;24(2):230-235.
Ingestion of puffer fish can result in severe and potentially lethal intoxication, referred to as tetrodotoxin intoxication. Tetrodotoxin is a potent neurotoxin well known for its ability to ability neuromuscular...
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Methionine Enhances the Contractile Activity of Human Colon Circular Smooth Muscle In Vitro

Choe EK, Moon JS, Park KJ

Effective drug to manage constipation has been unsatisfactory. We sought to determine whether methionine has effect on the human colon. Human colon tissues were obtained from the specimens of colon...
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A Series of Cases of Fukuda Classification Grade IV Tetrodotoxin Poisoning due to Ingestion of Tetrodotoxin from Puffer Fish

Wi DH

  • KMID: 2333076
  • J Korean Soc Emerg Med.
  • 2012 Feb;23(1):154-159.
Ingestion of the eyes and many of the internal organs of puffer fish can result in severe and potentially lethal intoxication, but there is little available information regarding the results...
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Somatostatin Inhibits Gonadotropin Releasing Hormone Neuronal Activities in Juvenile Mice

Park SA, Bhattarai , Han SK

BACKGROUND: The gonadotropin releasing hormone (GnRH) neurons perform a pivotal function in the central regulation of fertility. Somatostatin (SST) is an important neuromodulatory peptide in the central nervous system and...
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Clinical Analysis of Puffer Fish Poisoning Cases

Hyun SH, Sohn CH, Ryoo SM, Oh BJ, Lim KS

  • KMID: 2101642
  • J Korean Soc Clin Toxicol.
  • 2011 Dec;9(2):95-100.
PURPOSE: Ingestion of puffer fish can be poisonous due to the presence of potent neurotoxins such as tetrodotoxin (TTX) found in its tissues. There are few clinical reports related to...
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Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by beta-adrenoceptor

Endale M, Song JC, Rhee MH, Liu KH, Kim TK, Kwon JG, Park KS, Chung KM, Kim TW

Suaeda asparagoides (Miq.) has long been used as a Korean folk herbal medicine for the treatment of functional gastrointestinal disorders. However, reports on its pharmacological activity on gastrointestinal motility are...
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Glycine- and GABA-mimetic Actions of Shilajit on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis in Mice

Yin H, Yang EJ, Park SJ, Han SK

Shilajit, a medicine herb commonly used in Ayurveda, has been reported to contain at least 85 minerals in ionic form that act on a variety of chemical, biological, and physical...
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Characteristics of 5-Hydroxytryptamine Receptors Involved in Contraction of Feline Ileal Longitudinal Smooth Muscle

Wang Y, Park SY, Oh KH, Min Y, Lee YJ, Lee SY, Sohn UD

A number of studies have demonstrated that 5-hydroxytryptamine (5-HT) can induce muscle contraction or relaxation response and enhance secretion in the gastrointestinal tract via a multiplicity of 5-HT receptor subtypes....
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Change of Tetrodotoxin Sensitive Inhibitory Neural System of the Colon in Spinal Cord Injured Rats

Joo MC, Lee SH, Oh JT, Jo HJ, Park HI, Lim YH, Choi SC, Lee MY

  • KMID: 2326070
  • J Korean Acad Rehabil Med.
  • 2010 Aug;34(4):387-393.
OBJECTIVE: To investigate the effect of spinal cord injury (SCI) on contractions of whole colonic preparation isolated from rats under the inhibition of nitrergic inhibitory neural system using tetrodotoxin (TTX). METHOD:...
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MLCK and PKC Involvements via Gi and Rho A Protein in Contraction by the Electrical Field Stimulation in Feline Esophageal Smooth Muscle

Park SY, Shim JH, Kim M, Sun YH, Kwak HS, Yan X, Choi BC, Im C, Sim SS, Jeong JH, Kim IK, Min YS, Sohn UD

We have shown that myosin light chain kinase (MLCK) was required for the off-contraction in response to the electrical field stimulation (EFS) of feline esophageal smooth muscle. In this study,...
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