- A case of myelodysplastic syndrome after oral methotrexate overdose
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Kim SY, Lim JH, Han KJ
- KMID: 2225977
- Korean J Clin Pathol.
- 2000 Dec;20(6):548-550.
Methotrexate is a very potent inhibitor of dihydrofolate reductase and causes bone marrow suppression and megaloblastic anemia. It is widely used in combination with other chemotherapeutic agents in lymphoproliferative disorders.... -
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- A Case of Splenic Non-Hodgkin's Lymphoma in Rheumatoid Arthritis
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Lee HJ, Koh JW, Park JH, Park SN, Lee K, Shin HJ, Lee CW
- KMID: 2334832
- J Korean Rheum Assoc.
- 2005 Dec;12(4):324-328.
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder of unknown etiology. Inflammation may usually extend beyond the joints and involve other organs. Clinically detectable splenomegaly is present in 5~10%... -
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- Influence of Reduced Folate Carrier and Dihydrofolate Reductase Genes on Methotrexate-Induced Cytotoxicity
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Yoon SA, Choi JR, Kim JO, Shin JY, Zhang X, Kang JH
- KMID: 2270806
- Cancer Res Treat.
- 2010 Sep;42(3):163-171.
PURPOSE: The aim of this study is to investigate the effect of genetic variations and the expression of the reduced folate carrier (RFC) and dihydrofolate reductase (DHFR) on the drug... -
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- Elevated folic acid results in contrasting cancer cell line growth with implications for mandatory folic acid fortification
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Yates Z, Lucock M, Veysey M, Choi JH
- KMID: 2209844
- J Nutr Health.
- 2016 Apr;49(2):72-79.
- doi: 10.4163/jnh.2016.49.2.72
PURPOSE: The initiation of mandatory folic acid fortification using pteroylmonoglutamic acid (PteGlu) has reduced the rate of congenital malformations. However, it also appears to be responsible for several adverse effects,... -
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- Genetic Polymorphisms in Plasmodium vivax Dihydrofolate Reductase and Dihydropteroate Synthase in Isolates from the Philippines, Bangladesh, and Nepal
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Thongdee P, Kuesap J, Rungsihirunrat K, Dumre SP, Espino E, Noedl H, Na-Bangchang K
- KMID: 2381822
- Korean J Parasitol.
- 2015 Apr;53(2):227-232.
- doi: 10.3347/kjp.2015.53.2.227
Genetic polymorphisms of pvdhfr and pvdhps genes of Plasmodium vivax were investigated in 83 blood samples collected from patients in the Philippines, Bangladesh, and Nepal. The SNP-haplotypes of the pvdhfr... -
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- Pharmacogenomic Assessment of Outcomes of Pemetrexed-Treated Patients with Adenocarcinoma of the Lung
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Jung M, Lee CH, Park HS, Lee JH, Kang YA, Kim SK, Chang J, Kim DJ, Rha SY, Kim JH, Cho BC
- KMID: 2158218
- Yonsei Med J.
- 2013 Jul;54(4):854-864.
- doi: 10.3349/ymj.2013.54.4.854
PURPOSE: The main objective of this study was to evaluate the association between polymorphisms of the target genes of pemetrexed and clinical outcomes in non-small cell lung cancer (NSCLC) patients... -
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- Increased levels of multiple forms of dihydrofolate reductase in peripheral blood leucocytes of cancer patients receiving haematopoietic colony-stimulating factors: interim analysis
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Iqbal MP, Burney IA, Sultana F, Mehboobali N, Siddiqui T
- KMID: 1109307
- Exp Mol Med.
- 2000 Jun;32(2):84-87.
The precise mechanism whereby granulocytes proliferate when haematopoietic colony stimulating factors (CSFs) are used in neutropenic cancer patients is poorly understood. The purpose of this study was to investigate whether... -
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- Changes in enzyme activity and expression of DHFR of Toxoplasma gondii by antifolates
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Baek EJ, Nam HW
- KMID: 662563
- Korean J Parasitol.
- 1998 Sep;36(3):191-198.
- doi: 10.3347/kjp.1998.36.3.191
The responses to antifolates of Toxoplasma gondii were investigated by measuring the dihydrofolate reductase (DHFR) activity, quantity of DHFR mRNA, and single-strand conformational polymorphism (SSCP) pattern. Pyrimethamine (PYM) and methotrexate... -
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- Plasmodium vivax dhfr Mutations among Isolates from Malarious Areas of Iran
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Zaman J, Shahbazi A, Asgharzadeh M
- KMID: 1090611
- Korean J Parasitol.
- 2011 Jun;49(2):125-131.
- doi: 10.3347/kjp.2011.49.2.125
The use of sulfadoxine and pyrimethamine (SP) for treatment of vivax malaria is uncommon in most malarious areas, but Plasmodium vivax isolates are exposed to SP because of mixed infections... -
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