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An Updated Review of Chronic Lymphocytic Leukemia

Cho HJ, Sohn SK

Chronic lymphocytic leukemia (CLL), characterized by monoclonal B-cell accumulation and highly variable clinical manifestations that range from an indolent to an aggressive course, is rare in Korea. Asymptomatic patients with...
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Pulmonary toxicities of molecular targeted antineoplastic agents: a single-center 10-year experience

Lee MY, Yoon SY, Kim KH, Lee N, Kim HY, Hwang JH, Won JH

Background/Aims: A better understanding of cancer cell biology has led to the discovery and development of several new targeted agents for cancer. These drugs are widely used in cancer treatment...
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Optimizing the management of intermediate-stage hepatocellular carcinoma: Current trends and prospects

Torimura T, Iwamoto H

Hepatocellular carcinoma (HCC) is usually accompanied by chronic liver damage, which sometimes influences the selection of HCC treatment. The Barcelona Clinic Liver Cancer (BCLC) staging system, which was first introduced...
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Elucidating molecular mechanisms of acquired resistance to BRAF inhibitors in melanoma using a microfluidic device and deep sequencing

Han J, Jung Y, Jun Y, Park S, Lee S

BRAF inhibitors (e.g., vemurafenib) are widely used to treat metastatic melanoma with the BRAF V600E mutation. The initial response is often dramatic, but treatment resistance leads to disease progression in...
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Structure of SARS-CoV-2 Spike Glycoprotein for Therapeutic and Preventive Target

Hong J, Jhun H, Choi YO, Taitt AS, Bae S, Lee Y, Song Cs, Yeom SC, Kim S

The global crisis caused by the coronavirus disease 2019 (COVID-19) led to the most significant economic loss and human deaths after World War II. The pathogen causing this disease is...
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Advantages and disadvantages of targeted therapy in patients with rheumatoid arthritis

Sung YK

With the recent understanding of the pathogenesis of rheumatoid arthritis at the cellular and molecular levels, as well as the rapid progress of biotechnology, targeted therapies have been developed and...
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New Molecular Targeted Therapy of Metastatic Colorectal Cancer

Jo J

Over the past decade, substantial advances have been made in the individualization of therapeutic strategies for metastatic colorectal cancer (mCRC). Treatment strategies have been developed and classified according to their...
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TM4SF4 and LRRK2 Are Potential Therapeutic Targets in Lung and Breast Cancers through Outlier Analysis

Jung K, Choi JS, Koo BM, Kim YJ, Song JY, Sung M, Chang ES, Noh KW, An S, Lee MS, Song K, Lee H, Kim RN, Shin YK, Oh DY, Choi YL

Purpose To find biomarkers for disease, there have been constant attempts to investigate the genes that differ from those in the disease groups. However, the values that lie outside the overall...
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Caspase Recruitment Domain Containing Protein 9 Suppresses Non-Small Cell Lung Cancer Proliferation and Invasion via Inhibiting MAPK/p38 Pathway

Pan L, Tan Y, Wang B, Qiu W, Yin Y, Ge H, Zhu H

Purpose Caspase recruitment domain containing protein 9 (CARD9) has been demonstrated to be a pro-tumor factor in various cancers. However, our previous study found a significant decrease of CARD9 in malignant...
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Clinical response and safety of apatinib monotherapy in recurrent, metastatic cervical cancer after failure of chemotherapy:a retrospective study

Xiao Y, Cheng H, Wang L, Yu X

Objective: To observe the safety and short-term efficacy of apatinib in the treatment of recurrent, metastatic cervical cancer in patients who have already received more than two kinds of comprehensive...
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Targeted Therapy for Non-Small Cell Lung Cancer

Kim JS, Kang EJ

Treatment of progressive non-small cell lung cancer (NSCLC) has advanced remarkably, due in part to the development of targeted therapies. Several gene alterations, including EGFR, ALK, ROS1, and BRAF, play...
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Bone Health Issues in Patients with Prostate Cancer: An Evidence-Based Review

Walz S, Maas M, Stenzl A, Todenhöfer T

Bone health in prostate cancer patients represents a prerequisite for acceptable quality of life and optimal outcome of this disease. The major threat for bone health in prostate cancer displays...
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Optimized Image-Based Surrogate Endpoints in Targeted Therapies for Glioblastoma: A Systematic Review and Meta-Analysis of Phase III Randomized Controlled Trials

Suh CH, Kim HS, Jung SC, Choi CG, Kim SJ, Kim KW

OBJECTIVE: We aimed to determine the optimized image-based surrogate endpoints (IBSEs) in targeted therapies for glioblastoma through a systematic review and meta-analysis of phase III randomized controlled trials (RCTs). MATERIALS AND...
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Survival prognoses of Heng intermediate-risk patients with metastatic renal cell carcinoma treated with immunotherapy or targeted therapy: A real-world, single-center retrospective study

Kim SH, Lee DE, Joung JY, Seo HK, Lee KH, Chung J

PURPOSE: This study aimed to compare progression-free survival (PFS), overall survival (OS), and cancer-specific survival (CSS) in Heng intermediate-risk patients with metastatic renal cell carcinoma (mRCC) treated with first-line immunotherapy...
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Roles of the complement system in alcohol-induced liver disease

Zhou Y, Yuan G, Zhong F, He S

Alcohol-induced liver disease (ALD) is a complex disorder, with a disease spectrum ranging from steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Although the pathogenesis of ALD is incompletely understood and...
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Current Development and Research Trend of Chemotherapeutic Agents for Head and Neck Squamous Cell Carcinoma

Lee YS

After FDA approval of cetuximab at 2006, receptor tyrosine kinase, including an epidermal growth factor receptor, blocking agents have been evaluated for head and neck squamous cell carcinoma (HNSCC). Agents...
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Clinical Implementation of Precision Medicine in Gastric Cancer

Jeon J, Cheong JH

Gastric cancer (GC) is one of the deadliest malignancies in the world. Currently, clinical treatment decisions are mostly made based on the extent of the tumor and its anatomy, such...
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Chemotherapy for Lung Cancer in the Era of Personalized Medicine

Lee SH

Although recent advances in molecular targeted therapy and immuno-oncology have revolutionized the landscape of lung cancer therapeutics, cytotoxic chemotherapy remains an essential component of lung cancer treatment. Extensive evidence has...
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The 34th Annual Meeting of the Korean Society of Gynecologic Oncology 2019: meeting report

Yim GW, Suh DH, Kim JW, Kim SC, Kim YT

The 34th Annual Meeting of Korean Society of Gynecologic Oncology (KSGO) was held in Busan, Korea from 26 to 27 April. Around 460 Korean and international clinicians gathered in Busan...
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The Cancer Precision Medicine Diagnosis and Treatment (K-MASTER) Enterprise

Choi YJ, Kim YH

“Precision” trials, using reasonably integrated biomarker targets and molecularly selective anticancer agents, have become a major concern for both patients and their physicians. As next-generation sequencing, which is a parallel...
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