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Cerebrovascular reactivity to hypercapnia during sevoflurane or desflurane anesthesia in rats

Sakata K, Kito K, Fukuoka N, Nagase K, Tanabe K, Iida H

BACKGROUND: Hypercapnia causes dilation of cerebral vessels and increases cerebral blood flow, resulting in increased intracranial pressure. Sevoflurane is reported to preserve cerebrovascular carbon dioxide reactivity. However, the contribution of...
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Impact of preoperative proteinuria on renal functional outcomes after open partial nephrectomy in patients with a solitary kidney

Tachibana , Kondo T, Takagi T, Okumi M, Tanabe K

PURPOSE: To assess the impact of proteinuria on postoperative renal function after open partial nephrectomy (OPN) in patients with a solitary kidney and analyze predictive factors for developing chronic kidney...
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Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits

Michino T, Tanabe K, Takenaka M, Akamatsu S, Uchida M, Iida M, Iida H

Background: Cerebral blood flow (CBF) has direct effects on neuronal function and neurocognitive disorders. Oxidative stress from abdominal aortic surgery is important in the pathophysiology of CBF impairment....
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