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Achalasia: The Current Clinical Dilemma and Possible Pathogenesis

Jia X, Chen S, Zhuang Q, Tan N, Zhang M, Cui Y, Wang J, Xing X, Xiao Y

  • KMID: 2541566
  • J Neurogastroenterol Motil.
  • 2023 Apr;29(2):145-155.
  • doi: 10.5056/jnm22176
Achalasia is a primary esophageal motility disorder manifested by dysphagia and chest pain that impair patients’ quality of life, and it also leads to chronic esophageal inflammation by food retention...
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Psychosis, Treatment Emergent Extrapyramidal Events, and Subsequent Onset of Huntington's Disease: A Case Report and Review of the Literature

Xu C, Yogaratnam J, Tan N, Sim K

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease characterized by a triad of progressive motor dysfunction, cognitive decline and psychiatric disturbances. The hallmark of HD is the distinctive choreiform...
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Upright Integrated Relaxation Pressure Predicts Symptom Outcome for Esophagogastric Junction Outflow Obstruction

Chen S, Liang M, Tan N, Zhang M, Lin Y, Cao P, Zhuang Q, Xiao Y

  • KMID: 2517530
  • J Neurogastroenterol Motil.
  • 2021 Jul;27(3):363-369.
  • doi: 10.5056/jnm20106
Background/Aims Esophagogastric junction outflow obstruction (EGJOO) is characterized by elevated integrated relaxation pressure (IRP) and preserved esophageal peristalsis. The clinical significance of EGJOO is uncertain. This study aim to describe the...
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Acid Exposure Time > 6% Might Not Improve the Therapeutic Outcome in Chinese Gastroesophageal Reflux Disease Patients

Lin Y, Li Y, Liang M, Tan N, Zhang M, Chen S, Xiao Y

  • KMID: 2510062
  • J Neurogastroenterol Motil.
  • 2021 Jan;27(1):55-62.
  • doi: 10.5056/jnm19219
Background/Aims There is less acid burden in Chinese gastroesophageal reflux disease (GERD) patients. However, the Lyon consensus proposed a higher threshold of acid exposure time (AET > 6%) for GERD. The...
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Esophagogastric Junction Contractility Integral Reflect the Anti-reflux Barrier Dysfunction in Patients with Gastroesophageal Reflux Disease

Xie C, Wang J, Li Y, Tan N, Cui Y, Chen M, Xiao Y

  • KMID: 2367452
  • J Neurogastroenterol Motil.
  • 2017 Jan;23(1):27-33.
  • doi: 10.5056/jnm16008
BACKGROUND/AIMS: Anti-reflux barrier dysfunction is one of the primary mechanisms in gastroesophageal reflux disease (GERD) pathogenesis. The esophagogastric junction contractile integral (EGJ-CI) is a new metric adopted to evaluate the...
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