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Reduced ceramides are associated with acute rejection in liver transplant patients and skin and hepatocyte transplant mice

Kim N, Yoo HJ, Kang Y, Kim SJ, Yoon YI, Lee Y, Tak E, Kim JJ, Hwang S, Jung DH

We set up this study to discover novel metabolic biomarkers for acute rejection and understand the roles of ceramides on im-mune cells in acute rejection. Serum concentrations of ceramides and...
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Synergistic effect of metformin on sorafenib in in vitro study using hepatocellular carcinoma cell lines

Chung YG, Tak E, Hwang S, Lee JY, Kim JY, Kim YY, Song GW, Lee KJ, Kim N

BACKGROUNDS/AIMS: Hepatocellular carcinoma (HCC) recurrence remains a great concern following hepatic resection and liver transplantation. We investigated the metformin-induced cytotoxic effects on sorafenib in an in vitro study using HCC...
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An interim safety analysis of hepatocellular carcinoma patients administrating oral vitamin K with or without sorafenib

Jung DH, Hwang S, Song GW, Ryoo BY, Kim N, Tak E, Hong HN

BACKGROUNDS/AIMS: Vitamin K may plays a role in controlling hepatocellular carcinoma (HCC) cell growth. In this study, we intended to present 5-year experience of 72 patients receiving oral vitamin K...
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Antibody Response Induced by Two Doses of ChAdOx1 nCoV-19, mRNA-1273, or BNT162b2 in Liver Transplant Recipients

Lim SY, Yoon YI, Kim JY, Tak E, Song GW, Kim SH, Lee SG

Coronavirus disease 2019 (COVID-19) vaccination in immunocompromised, especially transplant recipients, may induce a weaker immune response. But there are limited data on the immune response after COVID-19 vaccination in liver...
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Association between pretransplant serum soluble programmed death protein 1 level and prognosis following liver transplantation in patients with hepatocellular carcinoma

Oh K, Hwang S, Ahn CS, Kim KH, Moon DB, Ha TY, Song GW, Jung DH, Lee KJ, Tak E

Background: The study aimed to assess the prognostic influence of pretransplant serum soluble programmed death protein 1 (sPD-1) in patients undergoing liver transplantation (LT) for treatment of hepatocellular carcinoma (HCC). Methods:...
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High-dose tenofovir is not effective in suppressing hepatitis B virus replication in patients with hepatocellular carcinoma progression: a preliminary result

Hwang S, Song GW, Jung DH, Yoon YI, Yoo HJ, Tak E

BACKGROUNDS/AIMS: Nucleos(t)ide analogues (NUCs) effectively suppress hepatitis B virus (HBV) replication, but hepatocellular carcinoma (HCC) recurrence often leads to HBV replication despite NUC therapy. The aim of this study was...
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Different antibody responses between liver and kidney transplant recipients elicited by third doses of COVID-19 mRNA vaccines

Lim SY, Yoon YI, Kim JY, Tak E, Kwon H, Shin S, Kim YH, Song GW, Kim SH, Lee SG

Background: Solid organ transplant recipients exhibit decreased antibody responses, mainly due to their weakened immune systems. However, data are limited on antibody responses after the primary series of coronavirus disease...
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In vitro immune cell monitoring as a guide for long-term immunosuppression in adult liver transplant recipients

Jwa E, Hwang S, Kwon YJ, Kim N, Song GW, Jung DH, Ahn CS, Tak E, Moon DB, Kim KH, Ha TY, Park GC, Lee SG

BACKGROUNDS/AIMS: We evaluated the clinical usability of immune cell monitoring in adult liver transplantation (LT) recipients. METHODS: This study was composed of two parts as using calcineurin phosphatase (CNP) activity assay...
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Validation of the OncoHepa test, a multigene expression profile test, and the tumor marker-volume score to predict postresection outcome in small solitary hepatocellular carcinomas

Ha SM, Hwang S, Park JY, Lee YJ, Kim KH, Song GW, Jung DH, Yu YS, Kim J, Lee KJ, Tak E, Park YH, Lee SG

PURPOSE: OncoHepa test is a multigene expression profile test developed for assessment of hepatocellular carcinoma (HCC) prognosis. Multiplication of α-FP, des-γ-carboxy prothrombin (DCP) and tumor volume (TV) gives the α-FP-DCP-volume...
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Methionine Adenosyltransferase 1: A Proteomic Surrogate Marker of Early Hepatocellular Carcinoma in Cirrhotic Patients

Lee JH, Jun MJ, Shim JH, Song GW, Tak E, Oh B, Yu E, Choi SW, An J, Lee D, Kim KM, Lim YS, Lee HC, Chung YH, Lee YS

BACKGROUND/AIMS: Because there is a lack of effective biomarkers, we aimed to discover proteomic candidate markers for hepatocellular carcinoma (HCC) in cirrhotic patients at the highest-risk of HCC, and to...
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