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Engineered Extracellular Vesicles as a Targeted Delivery Platform for Precision Therapy

Sun Y, Sun F, Xu W, Qian H

Extracellular vesicles (EVs)-based cell-free strategy has shown therapeutic potential in tissue regeneration. Due to their important roles in intercellular communications and their natural ability to shield cargos from degradation, EVs...
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N6-Methyladenosine Methyltransferase METTL3 Alleviates Diabetes-Induced Testicular Damage through Modulating TUG1/Clusterin Axis

Tian Y, Xiao YH, Sun C, Liu B, Sun F

Background: The present study investigated the regulatory effects of N6-methyladenosine (m6A) methyltransferase like-3 (METTL3) in diabetes-induced testicular damage. Methods: In vivo diabetic mice and high glucose (HG) treated GC-1 spg cells...
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Generation of Urothelial Cells from Mouse-Induced Pluripotent Stem Cells

Zhang D, Sun F, Yao H, Wang D, Bao X, Wang J, Wu J

Background and Objectives: The search for a suitable alternative for urethral defect is a challenge in the field of urethral tissue engineering. Induced pluripotent stem cells (iPSCs) possess multipotential for...
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A Comparative Study of the Effects of Different Decellularization Methods and Genipin-Cross-Linking on the Properties of Tracheal Matrices

Zhong Y, Jiang A, Sun F, Xiao Y, Gu Y, Wu L, Zhang Y, Shi H

BACKGROUND: Different decellularization methods can affect the integrity and the biomechanical and biocompatible properties of the tracheal matrix. Natural cross-linking with genipin can be applied to improve those properties. The...
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