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The Feasibility of Using Biomarkers Derived from Circulating Tumor DNA Sequencing as Predictive Classifiers in Patients with Small-Cell Lung Cancer

Feng Y, Liu Y, Yuan M, Dong G, Zhang H, Zhang T, Chang L, Xia X, Li L, Zhu H, Xing P, Wang H, Shi Y, Wang Z, Hu X

Purpose To investigate the feasibility of biomarkers based on dynamic circulating tumor DNA (ctDNA) to classify small cell lung cancer (SCLC) into different subtypes. Materials and Methods Tumor and longitudinal...
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Unexpected Presence of Blastocystis Subtype 1-3 DNA in Human Vaginal and Sperm Samples Coinfected with Trichomonas vaginalis

Villalobos G, Sanchez-Aguillon F, Carmona-Maldonado MV, Gonzalez-Arenas NR, Lopez-Escamilla E, Hernandez-Castro R, Romero-Valdovinos M, Martinez-Flores WA, Ramirez-Hinojosa JP, Maravilla P, Martinez-Hernandez F

There have been few reports on extra-enteric infections by Blastocystis STs and none have been molecularly identified in samples from human reproductive organs. We report for the first time the...
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Nano-BTA: A New Strategy for Intravesical Delivery of Botulinum Toxin A

Liu Q, Liao L

Botulinum neurotoxin subtype A (BoNT-A) has been part of the urology treatment arsenal since it was first used in the treatment of detrusor-sphincter dyssynergia more than 30 years ago. BoNT-A...
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Recent updates on the classification of hepatoblastoma according to the International Pediatric Liver Tumors Consensus

Jeong SU, Kang HJ

Hepatoblastoma is the most common pediatric liver malignancy and usually occurs within the first 3 years of life. In recent years, the overall incidence of hepatoblastoma has exhibited the greatest...
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Improving siRNA design targeting nucleoprotein gene as antiviral against the Indonesian H5N1 virus

Hartawan R, Pujianto DA, Dharmayanti NLPI, Soebandrio A

Background: Small interfering RNA technology has been considered a prospective alternative antiviral treatment using gene silencing against influenza viruses with high mutations rates. On the other hand, there are no reports...
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Soluble ACE2 and TMPRSS2 Levels in the Serum of Asthmatic Patients

Lee JH, Lee CE, Yoo Y, Shin E, An J, Park SY, Song WJ, Kwon HS, Cho YS, Moon HB, Kim TB

Background: Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine subtype 2 (TMPRSS2) are key proteins mediating viral entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although gene expressions of...
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Clinical Characteristics of Early Onset Cutaneous Malignant Melanoma in Korea

Lee EH, Lee SH, Park KD, Jang YH, Lee WJ, Lee SJ, Kim JY

  • KMID: 2522534
  • Korean J Dermatol.
  • 2021 Nov;59(9):659-668.
Background: Cutaneous malignant melanoma (CMM) develops mainly in the elderly, although it is often seen in young patients and in clinical practice. However, there are few studies on the clinical...
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Up-to-date Knowledge on the Pathological Diagnosis of Hepatocellular Carcinoma

Nahm JH, Park YN

Hepatocellular carcinoma (HCC) has heterogeneous molecular and pathological features and biological behavior. Large-scale genetic studies of HCC were accumulated, and a pathological-molecular classification of HCC was proposed. Approximately 35% of...
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Psychological Characteristics of Each Type According to Defense Mechanisms in Depression: Implications of Borderline Personality Organization Theory

Kim BR, Jeong HS, Jo Sh, Yun SH, Kim HG, Koo BH

Objectives: In this study, we divided the types of depression, focusing on defense mechanisms based on psychodynamic theory, and then explored the clinical and psychological characteristics of each group. Methods:...
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A Study of the Clinical Features of Rosacea and a Comparison of Its Classifications

Lim JS, Kwon ES, Myung KB, Cheong SH

  • KMID: 2520801
  • Korean J Dermatol.
  • 2021 Sep;59(8):624-633.
Background: Rosacea is a common chronic inflammatory skin disease, which primarily affects the central face. In 2002, the National Rosacea Society (NRS) committee developed the first diagnostic criteria for rosacea,...
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Cortical Thickness and Surface Area Abnormalities in Bipolar I and II Disorders

Woo Y, Kang W, Kang Y, Kim A, Han KM, Tae WS, Ham BJ

Objective Although bipolar II disorder (BD II) is not simply a mitigated form of bipolar I disorder (BD I), their neurobiological differences have not been elucidated. The present study aimed...
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Korean Medication Algorithm Project for Depressive Disorder 2021 (II): The Subtypes of Depression

Park YM, Seo JS, Woo YS, Bahk WM, Kim W, Jeong JH, Shim SH, Lee JG, Jang SH, Wang SM, Jung MH, Sung HM, Choo LH, Yoon BH, Lee SY, Jon DI, Min KJ

Objectives The Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) was developed in 2002 and revised in 2006, 2012, 2017. In 2021, the fifth edition was published. This edition reflected new...
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Dynamic Contrast Enhanced MRI and Intravoxel Incoherent Motion to Identify Molecular Subtypes of Breast Cancer with Different Vascular Normalization Gene Expression

Tsai WC, Chang KM, Kao KJ

Objective: To assess the expression of vascular normalization genes in different molecular subtypes of breast cancer and to determine whether molecular subtypes with a higher vascular normalization gene expression can...
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Characteristics of Impulsive and Premeditated Aggression Subtypes in Patients with Schizophrenia in South Korea Who Committed a Crime

Kim M, Jo Y, Lee TY, Lim KO, Kwon JS

Objectives: Although the characteristics of different aggression subtypes provide important information in establishing treatment and prevention strategies in schizophrenia patients, limited information is available about the characteristics of the aggressive...
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A Case of Lymphocyte-Rich Hepatocellular Carcinoma in a Patient Who Was Treated for Colon Cancer

Song JW, Chun HS, Lee JS, Lee HW, Kim BK, Kim SU, Park JY, Ahn SH, Park YN, Han DH, Kim DY

Hepatocellular carcinoma (HCC) primarily originates in the liver with hepatic differentiation. However, HCCs are not homogenous, and approximately 35% of HCC cases are classified as histopathological variants that present distinct...
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The nature of triple-negative breast cancer classification and antitumoral strategies

Kim S, Kim DH, Lee W, Lee YM, Choi SY, Han K

Identifying the patterns of gene expression in breast cancers is essential to understanding their pathophysiology and developing anticancer drugs. Breast cancer is a heterogeneous disease with different subtypes determined by...
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Development of reverse transcription loop-mediated isothermal amplification assays for point-of-care testing of avian influenza virus subtype H5 and H9

Zhang S, Shin J, Shin S, Chung YJ

Avian influenza (AIV) outbreaks can induce fatal human pulmonary infections in addition to economic losses to the poultry industry. In this study, we aimed to develop a rapid and sensitive...
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Cockroach as a Vector of Blastocystis sp. is Risk for Golden Monkeys in Zoo

Ma L, Zhang Y, Qiao H, Li S, Wang H, Zhang N, Zhang X

Blastocystis sp. is a kind of protozoa living in the intestinal tract of human and animals, which will cause intestinal diseases such as diarrhea, abdominal distension and vomiting. This paper...
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Analysis of HIV RNA Genotypes and Quantitative Values of HIV NAT Reactive Blood Donations

Kang Jw, Kang Jw, Ko DH, Youn M, Kwon SY

Background: The Korean Red Cross adopted HIV NAT for blood donor screening in 2005 using a minipool assay. In June 2012, the NAT system was replaced with the individual assay....
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Molecular Detection and Subtyping of Human Blastocystis and the Clinical Implications: Comparisons between Diarrheal and Non-diarrheal Groups in Korean Populations

Kim MJ, Won EJ, Kim SH, Shin JH, Chai JY

Blastocystis has recently been recognized as the most common eukaryotic microbe of the human gut. We investigated the prevalence of Blastocystis and their subtypes in diarrheal and non-diarrheal groups and...
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