- Unpredicted Severe Toxicity after 5-Fluorouracil Treatment due to Dihydropyrimidine Dehydrogenase Deficiency
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Baek JH, Kim JG, Kim SN, Kim DH, Sohn SK, Hong YJ, Lee KB
- KMID: 1782251
- Korean J Intern Med.
- 2006 Mar;21(1):43-45.
- doi: 10.3904/kjim.2006.21.1.43
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU). Thus, patients with a DPD deficiency are at risk of developing severe 5-FU-associated toxicity. A... -
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