- Long Non-Coding RNA TUG1 Attenuates Insulin Resistance in Mice with Gestational Diabetes Mellitus via Regulation of the MicroRNA-328-3p/SREBP-2/ERK Axis
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Tang X, Qin Q, Xu W, Zhang X
- KMID: 2540523
- Diabetes Metab J.
- 2023 Mar;47(2):267-286.
- doi: 10.4093/dmj.2021.0216
Background: Long non-coding RNAs (lncRNAs) have been illustrated to contribute to the development of gestational diabetes mellitus (GDM). In the present study, we aimed to elucidate how lncRNA taurine upregulated... -
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- Systematic Target Screening Revealed That Tif302 Could Be an OffTarget of the Antifungal Terbinafine in Fission Yeast
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Lee S, Nam M, Lee AR, Lee J, Woo J, Kang NS, Balupuri A, Lee M, Kim SY, Ro H, Choi YW, Kim DU, Hoe KL
- KMID: 2513492
- Biomol Ther.
- 2021 Mar;29(2):234-247.
- doi: 10.4062/biomolther.2020.166
We used a heterozygous gene deletion library of fission yeasts comprising all essential and non-essential genes for a microarray screening of target genes of the antifungal terbinafine, which inhibits ergosterol... -
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- Effects of a Portfolio-Mediterranean Diet and a Mediterranean Diet with or without a Sterol-Enriched Yogurt in Individuals with Hypercholesterolemia
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Ferro Y, Mazza E, Salvati M, Santariga E, Giampà S, Spagnuolo R, Doldo P, Pujia R, Coppola A, Gazzaruso C, Pujia A, Montalcini T
- KMID: 2503260
- Endocrinol Metab.
- 2020 Jun;35(2):298-307.
- doi: 10.3803/EnM.2020.35.2.298
Background: A growing number of functional foods have been proposed to reduce cholesterol levels and the Portfolio Diet, which includes a combination of plant sterols, fibres, nuts, and soy protein,... -
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- β-Sitosterol treatment attenuates cognitive deficits and prevents amyloid plaque deposition in amyloid protein precursor/presenilin 1 mice
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Ye JY, Li L, Hao QM, Qin Y, Ma CS
- KMID: 2466568
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):39-46.
- doi: 10.4196/kjpp.2020.24.1.39
Alzheimer's disease (AD) is the most common neurodegenerative disorder causing dementia worldwide, and is mainly characterized by aggregated β-amyloid (Aβ). Increasing evidence has shown that plant extracts have the potential... -
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- Quercetin induces cell death in cervical cancer by reducing O-GlcNAcylation of adenosine monophosphate-activated protein kinase
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Ali A, Kim MJ, Kim MY, Lee HJ, Roh GS, Kim HJ, Cho GJ, Choi WS
- KMID: 2430195
- Anat Cell Biol.
- 2018 Dec;51(4):274-283.
- doi: 10.5115/acb.2018.51.4.274
Hyper-O-GlcNAcylation is a general feature of cancer which contributes to various cancer phenotypes, including cell proliferation and cell growth. Quercetin, a naturally occurring dietary flavonoid, has been reported to reduce... -
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- Hyperlipidemic Inhibitory Effects of Phellinus pini in Rats Fed with a High Fat and Cholesterol Diet
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Im KH, Choi J, Baek SA, Lee TS
- KMID: 2428815
- Mycobiology.
- 2018 Jun;46(2):159-167.
- doi: 10.1080/12298093.2018.1461316
This study evaluated the in vitro and in vivo hypolipidemic effects of the medicinal mushroom Phellinus pini. The methanol extract (ME) of the fruiting body of Ph. pini was active... -
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- Corn silk extract improves cholesterol metabolism in C57BL/6J mouse fed high-fat diets
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Cha JH, Kim SR, Kang HJ, Kim MH, Ha AW, Kim WK
- KMID: 2434084
- Nutr Res Pract.
- 2016 Oct;10(5):501-506.
- doi: 10.4162/nrp.2016.10.5.501
BACKGROUND/OBJECTIVES: Corn silk (CS) extract contains large amounts of maysin, which is a major flavonoid in CS. However, studies regarding the effect of CS extract on cholesterol metabolism is limited.... -
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- High-Density Lipoprotein, Lecithin: Cholesterol Acyltransferase, and Atherosclerosis
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Ossoli A, Pavanello , Calabresi
- KMID: 2308851
- Endocrinol Metab.
- 2016 Jun;31(2):223-229.
- doi: 10.3803/EnM.2016.31.2.223
Epidemiological data clearly show the existence of a strong inverse correlation between plasma high-density lipoprotein cholesterol (HDL-C) concentrations and the incidence of coronary heart disease. This relation is explained by... -
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- Sitosterolemia: a review and update of pathophysiology, clinical spectrum, diagnosis, and management
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Yoo EG
- KMID: 2161300
- Ann Pediatr Endocrinol Metab.
- 2016 Mar;21(1):7-14.
- doi: 10.6065/apem.2016.21.1.7
Sitosterolemia is an autosomal recessive disorder characterized by increased plant sterol levels, xanthomas, and accelerated atherosclerosis. Although it was originally reported in patients with normolipemic xanthomas, severe hypercholesterolemia have been... -
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- Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk
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Jin L, Lin Z, Xu A
- KMID: 2383311
- Diabetes Metab J.
- 2016 Feb;40(1):22-31.
- doi: 10.4093/dmj.2016.40.1.22
Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on energy metabolism and insulin sensitivity. Besides its antiobese and antidiabetic activity, FGF21 also possesses the protective effects... -
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- Hypocholesterolemic metabolism of dietary red pericarp glutinous rice rich in phenolic compounds in mice fed a high cholesterol diet
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Park Y, Park EM, Kim EH, Chung IM
- KMID: 2313789
- Nutr Res Pract.
- 2014 Dec;8(6):632-637.
- doi: 10.4162/nrp.2014.8.6.632
BACKGROUND/OBJECTIVES: The purpose of the current study was to investigate the effect of red pericarp glutinous rice rich in polyphenols (Jakwangchalbyeo, red rice) on serum and hepatic levels of cholesterol... -
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- Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells
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Kim YM, Song I, Seo YH, Yoon G
- KMID: 2169308
- Endocrinol Metab.
- 2013 Dec;28(4):297-308.
- doi: 10.3803/EnM.2013.28.4.297
BACKGROUND: Enhanced lipogenesis plays a critical role in cell senescence via induction of expression of the mature form of sterol regulatory element binding protein 1 (SREBP1), which contributes to an... -
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- Fibrin glue increases the cell survival and the transduced gene product secretion of the ceiling culture-derived adipocytes transplanted in mice
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Aoyagi Y, Kuroda M, Asada S, Bujo H, Tanaka S, Konno S, Tanio M, Ishii I, Aso M, Saito Y
- KMID: 1109405
- Exp Mol Med.
- 2011 Mar;43(3):161-167.
- doi: 10.3858/emm.2011.43.3.021
The development of clinically applicable scaffolds is important for the application of cell transplantation in various human diseases. The aims of this study are to evaluate fibrin glue in a... -
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- Over-expression of Liver X Receptor-alpha(LXR alpha by TO901317 Exaggerated the Production of Mesangial Matrix
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Chin HJ, Fu YY, Song YR, Lee ES, Lee YM, Kim SG, Na KY, Kim S, Chae DW
- KMID: 2253063
- Korean J Nephrol.
- 2010 Mar;29(2):189-197.
PURPOSE: To provide the insight into the role of LXR alpha on the progression of diabetic nephropathy, we measured the production of extracellular matrix in the cultured mesangial cells treated... -
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- Sterol-independent repression of low density lipoprotein receptor promoter by peroxisome proliferator activated receptor gamma coactivator-1alpha (PGC-1alpha)
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Jeong JH, Cho S, Kim Pak Y
- KMID: 756233
- Exp Mol Med.
- 2009 Jun;41(6):406-416.
- doi: 10.3858/emm.2009.41.6.046
Peroxisome proliferator activated receptor (PPAR) gamma coactivator-1alpha (PGC-1alpha) may be implicated in cholesterol metabolism since PGC-1alpha co-activates estrogen receptor alpha (ERalpha) transactivity and estrogen/ERalpha induces the transcription of LDL receptor... -
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- Inhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes
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An S, Jang YS, Park JS, Kwon BM, Paik YK, Jeong TS
- KMID: 1094120
- Exp Mol Med.
- 2008 Aug;40(4):407-417.
- doi: 10.3858/emm.2008.40.4.407
We investigated the mechanism of spontaneous cholesterol efflux induced by acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibition, and how an alteration of cholesterol metabolism in macrophages impacts on that in HepG2 cells.... -
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- The Effect of Inulin Supplementation on Blood Lipid Levels, and Fecal Excretion of Bile Acid and Neutral Sterol in Korean Postmenopausal Women
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Lee EY, Kim YY, Jang KH, Kang SA, Choue R
- KMID: 2269785
- Korean J Nutr.
- 2004 Jun;37(5):352-363.
Lipid-lowering effects of the inulin have been demonstrated in animal, yet attempts to reproduce similar effects in humans have generated conflicting results. In this study, the lipid-lowering potential of inulin... -
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- The effect of plant sterol on serum cholesterol in patients with hypercholesterolemia
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Shin MJ, Rim SJ, Jang Y, Choi D, Kang SM, Cho SY, Kim SS, Kim D, Song K, Chung N
- KMID: 2029589
- Korean Circ J.
- 2001 Oct;31(10):1027-1033.
- doi: 10.4070/kcj.2001.31.10.1027
BACKGROUND AND OBJECT: Phytosterols(Plant sterols) have been known to reduce serum cholesterol concentrations by inhibiting absorption of both dietary and biliary cholesterol from the small intestines. However, the hypocholesterolemic effect... -
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- Thr-6Pro missense mutation in human lysosomal acid lipase (LAL) gene in patients with familial hypercholesterolemia in Korea
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Hwang HS, Hwang JH, Kim HS, Kim NK, Kim SJ, Lee CC, Chung KW
- KMID: 1540016
- J Genet Med.
- 1998 Dec;2(2):65-70.
Lysosomal acid lipase (LAL) plays a central role in the intracellular degradation of neutral lipids derived from plasma lipoproteins. In this study, we investigated the missense mutation within exon 2... -
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