- A case of 17 alpha-hydroxylase deficiency
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Kim SM, Rhee JH
- KMID: 1879368
- Clin Exp Reprod Med.
- 2015 Jun;42(2):72-76.
- doi: 10.5653/cerm.2015.42.2.72
17alpha-hydroxylase and 17,20-lyase are enzymes encoded by the CYP17A1 gene and are required for the synthesis of sex steroids and cortisol. In 17alpha-hydroxylase deficiency, there are low blood levels of... -
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- Limited Expression of Cytochrome P450 17alpha-Hydroxylase/17,20-Lyase in Prostate Cancer Cell Lines
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Jeong CW, Yoon CY, Jeong SJ, Hong SK, Byun SS, Lee SE
- KMID: 2315445
- Korean J Urol.
- 2011 Jul;52(7):494-497.
PURPOSE: Cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17A1) is a key enzyme in the androgen biosynthesis pathway. CYP17A1 has been focused on because of the promising results of a potent CYP17A1 inhibitor in... -
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- Functional Identification of Compound Heterozygous Mutations in the CYP17A1 Gene Resulting in Combined 17α-Hydroxylase/17,20-Lyase Deficiency
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Mo EY, Lee JY, Kim SY, Kim MJ, Kim ES, Lee S, Han JH, Moon SD
- KMID: 2447032
- Endocrinol Metab.
- 2018 Sep;33(3):413-422.
- doi: 10.3803/EnM.2018.33.3.413
BACKGROUND: We previously reported a patient with congenital adrenal hyperplasia (CAH) with compound heterozygous mutations in the cytochrome P450 17A1 (CYP17A1) gene. One allele had a p.His373Leu and the other... -
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- Association of the CYP17 gene polymorphism with the risk of advanced endometriosis in Korean women
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Hur SE, Kim MK, Lee SR, Lee JY, Moon HS, Chung HW
- KMID: 2128068
- Korean J Obstet Gynecol.
- 2005 Mar;48(3):695-700.
OBJECTIVE: To investigate whether polymorphism of CYP17 gene is associated with the risk of advanced endometriosis in Korean women. METHODS: The 194 endometriosis patients and 209 controls were enrolled. Blood samples... -
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- Association of the CYP17 gene polymorphism with the risk of PCOS in Korean women
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Lee JY, Cha YJ, Hur SE, Lee SJ, Sohn IS, Kim SN, Sung YA, Chung HW
- KMID: 2272611
- Korean J Obstet Gynecol.
- 2005 May;48(5):1306-1312.
OBJECTIVE: To investigate whether polymorphism of CYP17 gene is associated with the risk of polycystic ovary syndrome (PCOS) in Korean women. METHODS: The 86 PCOS patients and 75 controls were enrolled.... -
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- The role of angiotensin II to regulation of steroidogenic pathway in human ovarian follicle
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Lee HY, Ko DS, Kim HJ, Oh SO, Park WI, Hong SY, Shin JH, Lee JY, Cha BH
- KMID: 2077669
- Korean J Obstet Gynecol.
- 2006 Sep;49(9):1934-1940.
OBJECTIVE: The exact mechanism of angiotensin II to steroidogenesis is still speculative in spite of many researches especially in human and these were performed indirectly with serum or follicular fluid.... -
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- Adult granulosa cell tumors of the ovary: a retrospective study of 30 cases with respect to the expression of steroid synthesis enzymes
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Kitamura S, Abiko K, Matsumura , Nakai H, Akimoto Y, Tanimoto H, Konishi I
- KMID: 2413425
- J Gynecol Oncol.
- 2017 Jul;28(4):e31.
- doi: 10.3802/jgo.2017.28.e31
OBJECTIVE: Some, but not all, granulosa cell tumors are characterized by estrogen production. This study was designed to determine whether there are clinical or pathological variations in granulosa cell tumors... -
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- Genetic polymorphism of CYP17 and breast cancer risk in Korean women
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Shin MH, Lee KM, Yang JH, Nam SJ, Kim JW, Yoo KY, Park SK, Noh DY, Ahn SH, Kim B, Kang D
- KMID: 1033096
- Exp Mol Med.
- 2005 Feb;37(1):11-17.
CYP17 gene is involved in steroidogenesis and steroid metabolism. Epidemiologic results on the association between the CYP17 polymorphism and breast cancer risk have been inconsistent. We examined the association between... -
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