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Analgesic Effect of Toll-like Receptor 4 Antagonistic Peptide 2 on Mechanical Allodynia Induced with Spinal Nerve Ligation in Rats

Yin Y, Park H, Lee SY, Lee WH, Song HJ, Kim J, Kim DW, Hong J

Neuroinflammation is one of the key mechanisms of neuropathic pain, which is primarily mediated by the Toll-like receptor 4 (TLR4) signaling pathways in microglia. Therefore, TLR4 may be a reasonable...
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Spinal Nerve Position and Morphometric Analysis with Silicon Molds in the Cadaveric Lumbar Intervertebral Foramen

Kwon S

The intervertebral foramen is formed by two adjacent vertebrae and an intervertebral disc. Previous studies examining the foramen have been performed using various methods. The author obtained characteristics of the...
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Incarceration of Spinal Nerve Root through Incidental Durotomy as a Cause of Sciatica

Kim YJ

Incidental durotomies are a frequent complication during spinal surgery. Cerebrospinal fluid (CSF) leakage from a dural tear may be visually apparent intraoperatively, but occasionally, a tear may not be recognized...
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A Rare Case of Aggressive Melanotic Schwannoma Occurred in Spinal Nerve of a 59-Year-Old Male

Choi SE, Cha YJ, Kim J, Cha H, Seo J, Kuh SU, Kim SJ, Kim SH

Melanotic schwannoma (MS) is a rare variant of nerve sheath neoplasm that shows ultrastructural and immunophenotypical features of Schwann cells but also has cytoplasmic melanosomes and is reactive for melanocytic...
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The Effects of Comprehensive Education Program on Anxiety, Uncertainty and Athletic Performance of Patients undergo Spinal Nerve Block

Kim SH, Lee ES

PURPOSE: Purpose of the study was to identify the effect of the Comprehensive Education Program (CEP) on intraprocedure anxiety, post-procedure uncertainty and athletic performance of back strengthening of patients undergo...
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The Synergistic Effect of Intrathecally Administered Dexmedetomidine and Ketorolac on Mechanical Allodynia in Rats with Spinal Nerve Ligation

Cheong YK, Kim YD, Lee JH, Ham HD, Choi SW, Park SJ

OBJECTIVES: This research was carried out to identify the synergistic effect of dexmedetomidine and ketorolac on neuropathic pain alleviation. METHODS: The anti-allodynic effect of intrathecal dexmedetomidine and ketorolac was investigated in...
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The time-course and RNA interference of TNF-alpha, IL-6, and IL-1beta expression on neuropathic pain induced by L5 spinal nerve transection in rats

Choi BM, Lee SH, An SM, Park DY, Lee GW, Noh GJ

BACKGROUND: The objective of this study was to investigate the time-course of the expression of TNF-alpha, IL-6, and IL-1beta after L5 spinal nerve transection (SNT), and to determine the effect...
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Management of Patients with L2 Spinal Nerve Root Block Who Are Suffering from Low Back and Referred Pain

Ahn DK, Lee S, Kim TW, Hong SW, Jung WS

STUDY DESIGN: Prospective clinical study. OBJECTIVES: The aim of the study was to verify the effectiveness of L2 spinal nerve root block for patients who are suffering from low back pain...
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The effect of intrathecal curcumin on mechanical allodynia in rats after L5 spinal nerve ligation

Lee JH, Kim YD, Jung HC, Cheong YK

No abstract available.
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Synergistic anti-allodynic effect between intraperitoneal thalidomide and morphine on rat spinal nerve ligation-induced neuropathic pain

Lee HG, Kim WM, Yoon MH, Park AR, Choi JI

BACKGROUND: Thalidomide has been recognized as having an anti-allodynic effect against neuropathic pain induced by spinal nerve ligation. Its clinical beneficial effects are mainly derived from its immune-modulating property, which...
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A Case of Ancient Schwannoma Masquerading as Originating from Cervical Spinal Nerve

Yoon TM, Kim HD, Lee JK, Lim SC

  • KMID: 1922234
  • Korean J Otorhinolaryngol-Head Neck Surg.
  • 2007 Jul;50(7):643-645.
Schwannoma is a benign, solitary, and slow growing tumor which may arise from the nerve sheath of the peripheral, sympathetic, and cranial nerves. Ancient schwannoma is a rare variant of...
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Effect of Administering Freund's Complete Adjuvant to Spinal Nerves on the Development of Allodynia in the Rat

Park JY, Hwang JH

BACKGROUND: Spinal nerve ligation injury causes a neuropathic pain syndrome that includes allodynia. Neuropathic pain is also induced by Freund's complete adjuvant (FCA)-induced inflammation. This study was designed to examine...
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Change in the Expression of p75 Neurotrophin Receptor and TRPV1 in the Spinal Cord and Dorsal Root Ganglion after an Injury to the Spinal Nerves in Rats

Cho JL, Kang CN, Kim TS, Park YS, Baik DJ, Hwang SJ

  • KMID: 2398743
  • J Korean Orthop Assoc.
  • 2006 Aug;41(4):711-720.
PURPOSE: To determine the relationship between change in the expression of the p75 neurotrophin receptor (NTR) and transient receptor potential vanilloid 1 (TRPV1) after a spinal nerve injury with time. MATERIALS...
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Role of Peripheral Glutamate Receptors to Mechanical Hyperalgesia following Nerve Injury or Antidromic Stimulation of L5 Spinal Nerve in Rats with the Previous L5 Dorsal Rhizotomy

Jang JH, Nam TS, Yoon DM, Leem JW, Paik GS

BACKGROUND: Peripheral nerve injury leads to neuropathic pain, including mechanical hyperalgesia (MH). Nerve discharges produced by an injury to the primary afferents cause the release of glutamate from both central...
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Segmental Zoster Paresis Showing Spinal Nerve Roots Involvement on Gadolinium-Enhanced MRI

Choi JH, Ahn SH, Park YE, Kim DS

  • KMID: 1572464
  • J Korean Neurol Assoc.
  • 2006 Jun;24(3):274-277.
Segmental zoster paresis is a focal, asymmetric limb weakness caused by a herpes zoster infection. It is a rare complication of herpes zoster and the exact pathogenesis is uncertain. However,...
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Effects of 3-aminobenzamide (3-AB) on the alterations in primary afferent and spinal neurons induced by spinal nerve injury in rats.

Cho WJ, Cho HS, Hwang SJ, Baik DJ, Lee SE, Kim TS, Cho JR

  • KMID: 1575171
  • J Korean Orthop Res Soc.
  • 2006 Apr;9(1):76-88.
PURPOSE: The authors studied the effect of the 3-AB, an inhibitor of poly(ADP-ribose)polymerase (PARP), on the changes of primary afferents and spinal cord after spinal nerve injury. METHOD: The L5 and...
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Spinal Nerve Root Compression by Acute Inflammatory Granuloma after Spine Surgery: A case report

Kim DH, Hwang DS

This report describes a case of spinal nerve root compression due to an acute inflammatory granuloma after lumbar surgery. A 39 year-old man with a history of increasing back pain...
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Selective Spinal Nerve Block for the Treatment of Lumbar Spinal Stenosis that indicated Operation

Lee KH, Chung CW, Moon CW, Yoo JM, Choi JK, Kim YS

  • KMID: 2106153
  • J Korean Orthop Assoc.
  • 2005 Jun;40(3):321-325.
PURPOSE: This study evaluated the effectiveness of a selective nerve root block (SNRB) for a lumbar spinal stenosis (LSS) that indicated surgery. MATERIALS AND METHODS: Twenty-one LSS patients, who were...
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The Triple Entrapment Syndrome of the 5th Lumbar Spinal Nerve

Jang JS, Lee SH

  • KMID: 1956351
  • J Korean Neurosurg Soc.
  • 2005 Apr;37(4):258-262.
OBJECTIVE: The 5th lumbar spinal nerve can be entrapped in the intraspinal zone, foraminal zone, and the extraforaminal zone simultaneously. The failure to recognize that the nerve root can be...
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The Mechanical Antiallodynic Effect of Intrathecal Lamotrigine in Rats with Spinal Nerve Ligation

Song JG, Jun IG, Kwon MY, Park JY

BACKGROUND: A nerve ligation injury may produce a tactile allodynia. The effects of intrathecally delivered lamotrigine on allodynia induced due to fifth and sixth lumbar spinal nerves ligation in rats,...
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