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Oxytocin produces thermal analgesia via vasopressin-1a receptor by modulating TRPV1 and potassium conductance in the dorsal root ganglion neurons

Han RT, Kim HB, Kim YB, Choi K, Park GY, Lee PR, Lee J, Kim HY, Park CK, Kang Y, Oh SB, Na HS

Recent studies have provided several lines of evidence that peripheral administration of oxytocin induces analgesia in human and rodents. However, the exact underlying mechanism of analgesia still remains elusive. In...
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Incarceration of Spinal Nerve Root through Incidental Durotomy as a Cause of Sciatica

Kim YJ

Incidental durotomies are a frequent complication during spinal surgery. Cerebrospinal fluid (CSF) leakage from a dural tear may be visually apparent intraoperatively, but occasionally, a tear may not be recognized...
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Inhibiting Vascular Endothelial Growth Factor in Injured Intervertebral Discs Attenuates Pain-Related Neuropeptide Expression in Dorsal Root Ganglia in Rats

Sato J, Inage K, Miyagi M, Sakuma Y, Yamauchi K, Koda M, Furuya T, Nakamura J, Suzuki M, Kubota G, Oikawa Y, Sainoh T, Fujimoto K, Shiga Y, Abe K, Kanamoto H, Inoue M, Kinoshita , Norimoto M, Umimura T, Takahashi , Ohtori S, Orita S

STUDY DESIGN: An experimental animal study. PURPOSE: To evaluate effects of anti-vascular endothelial growth factor (VEGF) on the content and distribution of the calcitonin gene-related peptide (CGRP) in the dorsal ganglia...
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Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root Ganglion Neurons Innervating the Rat Stomach

Li M, Xue L, Zhu HY, Wang H, Xu X, Zhang PA, Wu G, Xu GY

  • KMID: 2387838
  • J Neurogastroenterol Motil.
  • 2017 Jul;23(3):464-476.
  • doi: 10.5056/jnm16161
BACKGROUND/AIMS: Gastric hypersensitivity contributes to abdominal pain in patients with functional dyspepsia. Recent studies showed that hormones induced by stress are correlated with visceral hypersensitivity. However, the precise mechanisms underlying...
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Enhanced Expression of TREK-1 Is Related with Chronic Constriction Injury of Neuropathic Pain Mouse Model in Dorsal Root Ganglion

Han HJ, Lee SW, Kim GT, Kim EJ, Kwon B, Kang D, Kim HJ, Seo KS

Neuropathic pain is a complex state showing increased pain response with dysfunctional inhibitory neurotransmission. The TREK family, one of the two pore domain K+ (K2P) channel subgroups were focused among...
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The Usefulness of Selective Spinal Nerve Root Block in Neuropathic Pain Patients with Radiculopathy

Shim DM, Kim TK, Song SY, Kim CS, Kwon BT, Jeon YD

PURPOSE: This study was conducted in order to evaluate effect and efficiency of selective spinal nerve root block for neuropathic pain patients with lower leg radiating pain. MATERIALS AND METHODS: A...
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Management of Patients with L2 Spinal Nerve Root Block Who Are Suffering from Low Back and Referred Pain

Ahn DK, Lee S, Kim TW, Hong SW, Jung WS

STUDY DESIGN: Prospective clinical study. OBJECTIVES: The aim of the study was to verify the effectiveness of L2 spinal nerve root block for patients who are suffering from low back pain...
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Identification of Differentially Expressed Genes by Gabapentin in Cultured Dorsal Root Ganglion in a Rat Neuropathic Pain Model

Heo JH, Lee SH, Chang KH, Han EH, Lee SG, Choi DW, Kim SW

  • KMID: 1502514
  • Biomol Ther.
  • 2013 Mar;21(2):126-131.
Neuropathic pain is a chronic pain disorder caused by nervous system lesions as a direct consequence of a lesion or by disease of the portions of the nervous system that...
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Pulsed Radiofrequency of Lumbar Dorsal Root Ganglia for Treatment of Chronic Inguinal Herniorrhaphy Pain: A case report

Kang SH, Han HJ, Kim WY, Kim DY, Moon DE

Inguinal hernia repair can result in paresthesia and/or pain in the inguinal region. Pharmacological and surgical management often yield inconsistent results associated with considerable risks and side effects. Radiofrequency thermocoagulation...
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Expression Profile of Tumor Endothelial Marker 7 and a Putative Ligand in the Rat Spinal Cord and Dorsal Root Ganglion

Wang L, Lee KY, Park HT, Kang DS

STUDY DESIGN: To analyze the expression profile of tumor endothelial marker 7 (TEM7) in the spinal cord and dorsal root ganglion (DRG). PURPOSE: To investigate the expression profile of TEM7...
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The Effect on Fos Expression in Rat Spinal Cord following Stimulation to Dorsal Root Ganglion by Pulsed Radiofrequency

Seo JH, Byeon WT, Kwon YB, Sim YJ

  • KMID: 2324592
  • J Korean Acad Rehabil Med.
  • 2007 Aug;31(4):387-393.
OBJECTIVE: To reconfirm the relationship between the Fos expression and the pulsed radiofrequency which very few articles have reported. METHOD: Thirty-four male Sprague-Dawely rats were enrolled: 8 for lumbar 3rd dorsal...
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Long Term Results of Microsurgical Dorsal Root Entry Zonotomy for Intractable Pain Associated with Brachial Plexus Injury

Park YB, Kim SH, Kim SW, Chang CH, Ahn SH, Jang SH

  • KMID: 2339823
  • J Korean Neurosurg Soc.
  • 2006 Sep;40(3):143-147.
OBJECTIVE: Brachial plexus injury can produce a intractable chronic neuropathic pain. This study was undertaken to assess the long term outcome of microsurgical dorsal root entry zonotomy(MDT). METHODS: Between October 1997...
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Change in the Expression of p75 Neurotrophin Receptor and TRPV1 in the Spinal Cord and Dorsal Root Ganglion after an Injury to the Spinal Nerves in Rats

Cho JL, Kang CN, Kim TS, Park YS, Baik DJ, Hwang SJ

  • KMID: 2398743
  • J Korean Orthop Assoc.
  • 2006 Aug;41(4):711-720.
PURPOSE: To determine the relationship between change in the expression of the p75 neurotrophin receptor (NTR) and transient receptor potential vanilloid 1 (TRPV1) after a spinal nerve injury with time. MATERIALS...
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Segmental Zoster Paresis Showing Spinal Nerve Roots Involvement on Gadolinium-Enhanced MRI

Choi JH, Ahn SH, Park YE, Kim DS

  • KMID: 1572464
  • J Korean Neurol Assoc.
  • 2006 Jun;24(3):274-277.
Segmental zoster paresis is a focal, asymmetric limb weakness caused by a herpes zoster infection. It is a rare complication of herpes zoster and the exact pathogenesis is uncertain. However,...
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The most appropriate antimitotic treatment of Ara-C in schwann cell-enriched culture from dorsal root ganglia of new born rat

Kim SM, Jahng JW, Lee JH

  • KMID: 2190357
  • J Korean Assoc Oral Maxillofac Surg.
  • 2006 Feb;32(1):42-51.
Schwann cell, one of important components of peripheral nervous system, interact with neurons to mutually support the growth and replication of embryonal nerves and to maintain the different functions of...
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Spinal Nerve Root Compression by Acute Inflammatory Granuloma after Spine Surgery: A case report

Kim DH, Hwang DS

This report describes a case of spinal nerve root compression due to an acute inflammatory granuloma after lumbar surgery. A 39 year-old man with a history of increasing back pain...
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Stereotactic S5 Dorsal Root Ganglionotomy Using Radiofrequency Lesion Generation: A case report

Kim IS, Bang KS, Lee JB, Hong SJ, Shin KM

Dorsal root ganglionotomy of the S5 nerve is useful for pain around the coccyx. The S5 dorsal root ganglion lies behind the sacrum at a level 1 cm caudal...
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Differential Expression of Somatostatin Receptor Subtype 2 in Dorsal Root Ganglia after Ischemic Injury in the Rat

Noh KC, Chung YK, Yoo JH, Jang WS, Lee JD, Won MH

  • KMID: 1901405
  • J Korean Orthop Assoc.
  • 2004 Dec;39(7):736-744.
PURPOSE: The somatostatin has been suggested to play a role in the transmission of neurotransmitters and the modulation of pain. Therefore, this study was carried out to investigate the spatial...
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Clinical Results of Radiofrequency Dorsal Root Entry Zone Coagulation for Paraplegic Pain

Lim SH, Kang JK, Kim YS

  • KMID: 1822217
  • J Korean Neurosurg Soc.
  • 2004 Aug;36(2):125-129.
OBJECTIVE: Dorsal root entry zone(DREZ) operation has been the most common surgical treatment for paraplegic pain in the past, but the results differ according to the patients. In this study,...
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Epidural Hyaluronic Acid in a Rat Model of Chronic Dorsal Root Ganglion Compression

Jeon YT, Hwang JW, Lim YJ, Kim YC, Lee SC

BACKGROUND: Hyaluronic acid (HA) is a naturally occurring polysaccharide that has been shown to be beneficial in various clinical settings, such as in opthalmic surgery or for intra-articular injections. This...
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