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Rho Guanine Nucleotide Exchange Factor 4 (Arhgef4) Deficiency Enhances Spatial and Object Recognition Memory

Yoo KS, Lee K, Lee YS, Oh WJ, Kim HK

  • KMID: 2508470
  • Exp Neurobiol.
  • 2020 Oct;29(5):334-343.
  • doi: 10.5607/en20049
Guanine nucleotide exchange factors (GEFs) play multiple functional roles in neurons. In a previous study, we reported that Arhgef4 (Rho guanine nucleotide exchange factor 4) functioned as a negative regulator...
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Theracurmin Ameliorates Cognitive Dysfunctions in 5XFAD Mice by Improving Synaptic Function and Mitigating Oxidative Stress

Kim J, Kim J, Huang Z, Goo N, Bae HJ, Jeong Y, Park HJ, Cai M, Cho K, Jung SY, Bae SK, Ryu JH

As the elderly population is increasing, Alzheimer's disease (AD) has become a global issue and many clinical trials have been conducted to evaluate treatments for AD. As these clinical trials...
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Visuospatial Dysfunction in Patients With the Right Vestibular Neuritis

Jeon SH, Kim KW, Shin HJ, Shin BS, Seo MW, Oh SY

Acute vestibular neuritis (VN) is characterized by acute/subacute vertigo with spontaneous nystagmus and unilateral loss of semicircular canal function. Vestibular system in human is represented in the brain bilaterally with...
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Pre-Mild Cognitive Impairment: Can Visual Memory Predict Who Rapidly Convert to Mild Cognitive Impairment?

Seo EH, Kim H, Choi KY, Lee KH, Choo IH

OBJECTIVE: Little is known about the natural course of pre-mild cognitive impairment (pre-MCI) and predictors to MCI. We followed-up individuals with pre-MCI and cognitively normal (CN) elders to identify neuropsychological...
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The Development and Validation of Memory Tasks Using Smart Devices for School Aged Children

Shin MS, Lee J, Eo Y, Oh S, Lee J, Kim I, Hong C

OBJECTIVES: The aim of this study was to develop auditory-verbal and visual-spatial memory tasks using smart devices for children aged 8 to 10 years and examine their validity. METHODS: One-hundred and...
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Effects of (−)-Sesamin on Memory Deficits in MPTP-lesioned Mouse Model of Parkinson's Disease

Zhao TT, Shin KS, Lee MK

This study investigated the effects of (−)-sesamin on memory deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model of Parkinson's disease (PD). MPTP lesion (30 mg/kg/day, 5 days) in mice showed memory deficits...
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The effects of superior cervical ganglionectomy on the ability of spatial memory using radial arm maze in the rats

Cho EJ, Park CM

  • KMID: 2169195
  • Anesth Pain Med.
  • 2011 Jan;6(1):54-58.
BACKGROUND: Stress, elevated sympathetic nervous system, glucocorticoid concentration affect learning and memory. The aim of this study was to evaluate the effects of superior cervical ganglionectomy on the spatial memory...
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Cognitive Dysfunction and Improvement after Antidepressant Treatment in Patients with Non-Psychotic Major Depressive Disorder in Mild to Moderate Severity: A Prospective Study

Lee KU, Cho SM, Park JI

  • KMID: 2287418
  • Korean J Psychopharmacol.
  • 2008 Sep;19(5):283-292.
OBJECTIVE: This study was conducted to evaluate the impairment of cognitive functions, which include verbal and visual memory, visuospatial function, and executive function, and also to investigate if there is...
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The Morris Water Maze Performance in Androgenized Female Rats: Sexual Dimorphisms in Spatial Memory and Effects of Testosterone

Shin SH, Park JM, Jung WY, Park MI, Seo YN, Kim SG, Kang CJ

  • KMID: 2341340
  • J Korean Neuropsychiatr Assoc.
  • 2007 Sep;46(5):518-522.
OBJECTIVES: It is widely accepted that gonadal steroids are involved in organization and activation of sexual dimorphism in the brain areas related with spatial learning. This study aimed to test...
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Correlation between Head Circumference and Visuospatial Ability of Elderly in Community

Kim KR, Lee KS, Hong CH, Cheong HK, Oh BH

  • KMID: 2334059
  • J Korean Geriatr Psychiatry.
  • 2007 Dec;11(2):83-90.
OBJECTIVES: The aim of this study is to find out the correlation between head circumference and visuospatial function of the elderly in community. METHODS: A total of 463 subjects (170 men...
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Correlation between Serum Estrogen and Spatial Memory in Peripartal Rats

Park MS, Park JM, Shin SH, Han KW, Kim MJ, Kim SG

  • KMID: 2341229
  • J Korean Neuropsychiatr Assoc.
  • 2006 Sep;45(5):453-458.
OBJECTIVES: This study was designed to find possible effect of pregnancy and parturition on spatial memory, especially in relation to levels of estrogen during the third trimester and postpartal period...
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Association of Schizophrenia with Pathological Aging : A Behavioral and Histological Study Using Animal Model

Cheon JS, Oh BH, Chang HI

  • KMID: 1834625
  • J Korean Soc Biol Psychiatry.
  • 1998 Jun;5(1):83-94.
OBJECTIVES: Phencyclidine(PCP) or PCP-like substances such as ketamine have been know to rekindle the cognitive dysfunction in schizophrenia. The aims of this study were to identify whether PCP-like substances can...
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