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Therapeutic Effect of a Novel Chimeric Molecule Targeting Both Somatostatin and Dopamine Receptors on Growth Hormone-Secreting Pituitary Adenomas

Kim J, Oh JH, Harlem H, Culler MD, Ku CR, Lee EJ

BACKGROUND: Acromegaly is a rare disease primarily caused by growth hormone (GH)-secreting pituitary adenomas, and its treatment is costly. Moreover, some patients are unresponsive to treatment. Hence, there are increasing...
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Medical Treatment with Somatostatin Analogues in Acromegaly: Position Statement

Chin SO, Ku CR, Kim BJ, Kim SW, Park KH, Song KH, Oh S, Yoon HK, Lee EJ, Lee JM, Lim JS, Kim JH, Kim KJ, Jin HY, Kim DJ, Lee KA, Moon SS, Lim DJ, Shin DY, Kim SH, Kwon MJ, Kim HY, Kim JH, Kim DS, Kim CH

Acromegaly is a chronic disorder caused by excessive growth hormone (GH) secretion. In most cases, the excess GH originates from GH-producing pituitary adenomas. Surgery is the preferred first-line treatment for...
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Medical Treatment with Somatostatin Analogues in Acromegaly: Position Statement

Chin SO, Ku CR, Kim BJ, Kim SW, Park KH, Song KH, Oh S, Yoon HK, Lee EJ, Lee JM, Lim JS, Kim JH, Kim KJ, Jin HY, Kim DJ, Lee KA, Moon SS, Lim DJ, Shin DY, Kim SH, Kwon MJ, Kim HY, Kim JH, Kim DS, Kim CH

The Korean Endocrine Society (KES) published clinical practice guidelines for the treatment of acromegaly in 2011. Since then, the number of acromegaly cases, publications on studies addressing medical treatment of...
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Incidental Detection of Parathyroid Adenoma on Somatostatin Receptor PET/CT and Incremental Role of ¹⁸F-Fluorocholine PET/CT in MEN1 Syndrome

Arora S, Damle NA, Passah A, Yadav MP, Ballal S, Aggarwal V, Gupta Y, Kumar P, Tripathi M, Bal C

Multiple endocrine neoplasia type 1 (MEN1) syndrome is characterized by combined occurrence of tumors of endocrine glands including the parathyroid, the pancreatic islet cells, and the anterior pituitary gland. Parathyroid...
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Up-regulation of NHE8 by somatostatin ameliorates the diarrhea symptom in infectious colitis mice model

Lei X, Cai L, Li X, Xu H, Geng C, Wang C

Na⁺/H⁺ exchangers (NHEs) have been shown to be involved in regulating cell volume and maintaining fluid and electrolyte homeostasis. Pooled evidences have suggested that loss of Na⁺/H⁺ exchanger isoform 8...
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Antitumor Effects of Somatostatin Analogs in Gastroenteropancreatic Neuroendocrine Tumors

Cho JH

No abstract available.
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Outcome of Endoscopic Transsphenoidal Surgery in Combination with Somatostatin Analogues in Patients with Growth Hormone Producing Pituitary Adenoma

Zhou T, Wang F, Meng X, Ba J, Wei S, Xu B

OBJECTIVE: To determine the efficacy of endoscopic surgery in combination with long-acting somatostatin analogues (SSAs) in treating patients with growth hormone (GH)-secreting pituitary tumor. METHODS: We performed retrospective analysis of 133...
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Changes in Somatostatin Receptor mRNA Levels by G Protein Mutation in GH3 Cells Which Show Responsiveness to Growth Hormone-Releasing Hormone

Kim EH, Sohn SJ, Lee MA, Seo SH, Ju SH, Lee D, Chung HJ, Jung JC, Park SJ

BACKGROUNDS: GH3 cells lack growth hormone(GH)-releasing hormone(GHRH) receptors. In this study, GH3 cells permanently transfected with human GHRH receptor cDNA(GH3-GHRHR cells), were established in order to examine the effects of...
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Regulation of L-type Calcium Channel Current by Somatostatin in Guinea-Pig Gastric Myocytes

Kim YC, Sim JH, Lee SJ, Kang TM, Kim SJ, Kim SR, Youn SJ, Lee SJ, Xu WX, So I, Kim KW

  • KMID: 2285316
  • Korean J Physiol Pharmacol.
  • 2005 Apr;9(2):103-108.
To study the direct effect of somatostatin (SS) on calcium channel current (IBa) in guinea-pig gastric myocytes, IBa was recorded by using whole-cell patch clamp technique in single smooth muscle...
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Differential Expression of Somatostatin Receptor Subtype 2 in Dorsal Root Ganglia after Ischemic Injury in the Rat

Noh KC, Chung YK, Yoo JH, Jang WS, Lee JD, Won MH

  • KMID: 1901405
  • J Korean Orthop Assoc.
  • 2004 Dec;39(7):736-744.
PURPOSE: The somatostatin has been suggested to play a role in the transmission of neurotransmitters and the modulation of pain. Therefore, this study was carried out to investigate the spatial...
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Immunoreactivity of Somatostatin Receptor Subtype 2 in Dorsal Root Ganglia in the Rat

Noh KC, Chung YK, Yoo JH, Park JS, Lee JD, Kang MC, Won MH, Kang TC, Park SK

  • KMID: 2106037
  • J Korean Orthop Assoc.
  • 2004 Feb;39(1):88-93.
PURPOSE: Somatostatin has been suggested to play a role in the transmission of neurotransmitters and in the modulation of pain. Of the different subtypes of somatostatin receptors 2, sstr2A and...
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Somatostatin Receptor

Kim E, Sohn S, Lee M, Park H, Jung J, Park S

  • KMID: 2200376
  • J Korean Soc Endocrinol.
  • 2003 Aug;18(4):342-355.
No abstract available.
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Modulation of Pituitary Somatostatin Receptor Subtype (sst1-5) mRNA Levels by Growth Hormone (GH) -Releasing Hormone in Purified Somatotropes

Park S, Park H, Lee M, Sohn S, Kim E, Jung J, Frohman LA, Kineman RD

  • KMID: 2285276
  • Korean J Physiol Pharmacol.
  • 2003 Apr;7(2):79-84.
We have previously reported that expression of the somatostatin receptor subtypes, sst1-5, is differentially regulated by growth hormone (GH) -releasing hormone (GHRH) and forskolin (FSK), in vitro. GHRH binds to...
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A prospective randomized controlled clinical trial comparing the effects of somatostatin and vasopressin for control of acute variceal bleeding in patients with liver cirrhosis

Lee HY, Lee HJ, Lee SM, Kim JH, Kweon SW, Lee BS, Kim NJ

  • KMID: 1866910
  • Korean J Med.
  • 2002 May;62(5):497-503.
BACKGROUND: Acute variceal bleeding is one of serious complications of liver cirrhosis that has an attendant mortality of approximately 60% during two years and a variety of treatments like balloon...
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Gene Expression of the Somatostatin Receptors, Gi2 alpha and Pit-1 alpha in GH3 Cells Permanently Transfected with a Mutant Gs alpha Gene

Park CY, Yang IM, Kim EH, Sohn SJ, Ryu MS, Woo JT, Kim SW, Kim JW, Kim YS, Choi YK, Park SJ

  • KMID: 2199910
  • J Korean Soc Endocrinol.
  • 2002 Apr;17(2):170-182.
BACKGROUND: Cyclic AMP stimulates the expression of the somatostatin (SRIF) receptor (sst1-5) and human growth hormone (GH)-secreting pituitary tumors with the gsp oncogene which increases intracellular cAMP levels, and shows...
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Gene Expression of Somatostatin Receptor (Subtype 2 & 5), Gi2 alpha and Pit-1 in GH-secreting Pituitary Adenomas

Ryu MS, Yang IM, Park CY, Woo JT, Kim SW, Kim JW, Kim YS, Choi YK, Kim EH, Park SJ, Kim KG

  • KMID: 2199901
  • J Korean Soc Endocrinol.
  • 2002 Apr;17(2):158-169.
BACKGROUND: Mutation of Gs protein subunit (gsp oncogene), detected in about 30~40% of growth hormone (GH)-secreting pituitary tumors, is associated with an increased long-acting somatostatin analog octreotide sensitivity. However, the...
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Comparison of Somatostatin and Vasopressin in the Control of Acute Esophageal Variceal Hemorrhage: A Prospective Randomized Trial

Chon CY, Jeong JI, Paik YH, Lee CK, Choe BH, Lee KS, Moon BS, Han KH, Moon YM, Kim DK

  • KMID: 2083057
  • Korean J Hepatol.
  • 2000 Dec;6(4):468-473.
BACKGROUND/AIMS: Although endoscopic band ligation or injection sclerotherapy are the current standard therapies for bleeding esophageal varices, the best method for initial control is unclear. The aim of this prospective...
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Effect of Acute Hyperglycemia - and Isoproterenol - induced Hypothalamic Somatostatin Release on the Thyroid Hormone Releasing Hormone - induced Thyroid Stimulating Hormone Secretion

Park CY, Yang IM, Oh SJ, Kim DY, Woo JT, Kim SW, Kim JW, Kim YS, Choi YK

  • KMID: 2199723
  • J Korean Soc Endocrinol.
  • 2000 Oct;15(4-5):486-492.
BACKGROUND: Acute hyperglycemia stimulates somatostatin (SRIH) release from the hypothalamus, and which in turn suppress growth hormone (GH) secretion and thyroid stimulating hormone (TSH) from the anterior pituitary gland. Beta-adrenergic...
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The Experience of Somatostatin Analogue in Various Pancreatic Diseases

Kim HY, Lee SS, Shin YR, Jun BM, Pyo SI, Park HJ, You KS, Seo DW, Lee SK, Kim MH, Min YI

  • KMID: 1857612
  • Korean J Gastroenterol.
  • 2000 Jun;35(6):784-789.
BACKGROUND/AIMS: Octreotide, long-acting analogue of somatostatin, has been used for symptomatic carcinoid syndrome and vasoactive intestinal peptide-producing tumors. In pancreatic diseases, however, the effect of octreotide has not been settled...
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A Case of Pancreatic Ascites Controlled with Somatostatin Analogue (Octreotide)

Pyo SI, Kim SY, Shin JH, Na BS, Jung SH, Park ET, Yoo KS, Lim BC, Seo DW, Lee SK, Kim MH, Min YI

  • KMID: 2240375
  • Korean J Gastroenterol.
  • 2000 Apr;35(4):517-521.
Pancreatic ascites has the characteristics of highly proteinaceous, amylase-rich intraperitoneal fluid. It usually occurs as a result of rupture of a pseudocyst or disruption of main pancreatic duct during the course of...
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