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Relationship between the Expression of Sodium Iodide Symporter and the Findings of 99mTc-MIBI Scintimammography in the Primary Breast Cancer

Seok JW, Kim SJ, Kwak HS, Lee CH, Kim IJ, Kim YK, Bae YT, Kim DS

  • KMID: 1614101
  • Korean J Nucl Med.
  • 2002 Dec;36(6):325-332.
No abstract available.
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Sodium Iodide Symporter (NIS) in the Management of Patients with Thyroid Carcinoma

Chung JK, Kim HW, Youn H, Cheon GJ

Although radioiodine has been applied in thyroid diseases including carcinoma for over 70 years, it was only in 1996 that the basic molecular mechanism of iodine uptake was identified. Iodide...
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Sodium Iodide Symporter and the Radioiodine Treatment of Thyroid Carcinoma

Chung JK, Youn HW, Kang JH, Lee HY, Kang KW

  • KMID: 2051960
  • Nucl Med Mol Imaging.
  • 2010 Apr;44(1):4-14.
Since the specific accumulation of iodide in thyroid was found in 1915, radioiodine has been widely applied to diagnose and treat thyroid cancer. Iodide uptake occurs across the membrane of...
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Updates of Radioiodine Treatment for Graves' Disease

Jeong SY

Radioiodine (RAI) has been used for the treatment of hyperthyroidism and is usually administered orally as sodium iodide (I-131) in solution or a capsule. However, this results in RAI being...
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Expression of Human Sodium Iodide Symporter mRNA in Papillary Thyroid Carcinoma

Kim HK, Ahn IM, Kim YI, Kim ES, Park HS, Park KY, Hong SJ

  • KMID: 2142204
  • J Korean Soc Endocrinol.
  • 1998 Jun;13(2):181-188.
BACKGROUND: The sodium iodide symporter(NIS) is a plasma membrane protein which is respoasibIe for iodide transport into thyroid cell. The cDNA sequence of NIS has recently been cloned from rat...
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Effect of LiCl on Iodine Kinetics in Thyroid Cancer Cell Lines Transduced by Recombinant Adenovirus Containing Sodium Iodide Symporter(NIS) Gene

Kim WB, Song JY, Han SM, Yeo JS, Lee HR, Shong YK, Moon DH

  • KMID: 2331172
  • J Korean Soc Endocrinol.
  • 2003 Apr;18(2):166-176.
BACKGROUND: Lithium is known to increase the retention of iodide in the thyroid gland, or in well differentiated thyroid cancer tissue. The effects of lithium on the function of the...
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Sunitinib-induced hypothyroidism

Kim SW

  • KMID: 2257384
  • Korean J Med.
  • 2009 Jan;76(1):33-36.
Sunitinib malate is a multi-targeted tyrosine kinase inhibitor used for gastrointestinal stromal tumor and renal cell carcinoma. It is also under phase II trial for use in advanced colon cancer,...
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Iododerma Following Radioactive Iodine Ablation of the Thyroid for Thyroid Cancer

Suh KS, Park JB, Han SH, Kim ST, Jang MS

  • KMID: 2038554
  • Korean J Dermatol.
  • 2013 Jan;51(1):53-56.
Iododerma is a rare cutaneous eruption that occurs after oral, parenteral or topical administration of iodides. Acneiform papulopustular lesions are the most common skin reactions of iododerma and erythematous, vesiculobullous,...
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Clinical Significance of Human Sodium Iodide Symporter mRNA Expressions in Primary and Metastatic Papillary Thyroid Carcinoma

Lee SJ, Park HJ, Lee EJ, Kim HY, Koh JK, Park KY, Kim SB, Gong GY, Hong SJ, Ahn IM, Kim SH

  • KMID: 2199508
  • J Korean Soc Endocrinol.
  • 1999 Sep;14(3):514-519.
BACKGROUND: The iodide transport into thyroid cells is an essential step in the biosynthesis of thyroid hormones. The sodium iodide symporter (NIS) which is responsible for iodide transport was cloned...
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Radioactive Iodine-Refractory Differentiated Thyroid Cancer and Redifferentiation Therapy

Liu J, Liu Y, Lin Y, Liang J

The retained functionality of the sodium iodide symporter (NIS) expressed in differentiated thyroid cancer (DTC) cells allows the further utilization of post-surgical radioactive iodine (RAI) therapy, which is an effective...
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RAI Treatment of Distant Metastasis of Thyroid Cancer

Kang KW

For the distant metastasis of differentiated thyroid cancers, such as papillary thyroid carcinoma, follicular thyroid carcinoma, and Hurthle cell carcinoma, radioiodine therapy is one of the standard treatment methods after...
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Molecular Imaging Using Sodium Iodide Symporter (NIS)

Cho JY

  • KMID: 2078807
  • Korean J Nucl Med.
  • 2004 Apr;38(2):152-160.
Radioiodide uptake in thyroid follicular epithelial cells, mediated by a plasma membrane transporter, sodium iodide symporter (NIS), provides a first step mechanism for thyroid cancer detection by radioiodide injection and...
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Comparison of Human Sodium/Iodide Symporter (hNIS) Gene Expressions between Lentiviral and Adenoviral Vectors in Rat Mesenchymal Stem Cells

Park SY, Kim SJ, Lee WW, Lee H, Kim HJ, Chung JK, Kim SE

  • KMID: 2051952
  • Nucl Med Mol Imaging.
  • 2008 Oct;42(5):394-400.
PURPOSE: Quantitative comparison of transgene expression within stem cells between lentivirus and adenovirus-mediated delivery systems has not been reported. Here, we evaluated the human sodium iodide symporter (hNIS) gene expression...
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Development of Dual Reporter System of Mutant Dopamine 2 Receptor (D2R) and Sodium Iodide Symporter (NIS) Transgenes

Hwang DW, Lee DS, Kang JH, Chang YS, Kim YH, Jeong JM, Chung JK, Lee MC

  • KMID: 1990860
  • Korean J Nucl Med.
  • 2004 Aug;38(4):294-299.
PURPOSE: Both human NIS and mutant D2R transgenes are proposed as reporting system in transplanted cell tracking. Using hepatoma cell lines, we constructed a dual reporter system containing human sodium-iodide...
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Sodium Iodide Symporter and Phosphatase and Tensin Homolog Deleted on Chromosome Ten Expression in Cholangiocarcinoma Analysis with Clinicopathological Parameters

Kim JH, Han SY, Lee SW, Baek YH, Kim HY, Kim JH, Jeong JS, Roh YH, Kim YH, Park BH, Kwon HJ, Cho JH, Nam KJ

  • KMID: 2053502
  • Gut Liver.
  • 2012 Jul;6(3):374-380.
BACKGROUND/AIMS: This study was performed to investigate the correlation of sodium iodide symporter (NIS) expression with the functionality and loss of phosphatase and tensin homolog deleted on chromosome ten (PTEN)...
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The Effect of Tanespimycin (17-AAG) on Radioiodine Accumulation in Sodium-Iodide Symporter Expressing Cells

Yu KH, Youn H, Song MG, Lee DS, Chung JK

  • KMID: 1427732
  • Nucl Med Mol Imaging.
  • 2012 Dec;46(4):239-246.
PURPOSE: The heat shock protein 90 inhibitor, tanespimycin, is an anticancer agent known to increase iodine accumulation in normal and cancerous thyroid cells. Iodine accumulation is regulated by membrane proteins...
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Enhanced Effect of Iodide - Uptake in Thyroid Carcinoma Cells by Infecting Adenovirus - Human Sodium Iodide Symporter (Ad - hNIS)

Park KK, Jin JS, Lee SJ, Park JY, Lee HR, Moon DH, Ahn IM, Chang HS

  • KMID: 2199730
  • J Korean Soc Endocrinol.
  • 2000 Oct;15(4-5):522-531.
BACKGROUND: The sodium-iodide-symporter (NIS) is a plasma membrane glycoprotein with 13 putative transmembrane domains, which is responsible for concentrating iodide into the thyroid by an active transport and provides the...
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Bilateral Renal Metastasis of Hürthle Cell Thyroid Cancer with Discordant Uptake Between I-131 Sodium Iodide and F-18 FDG

Claimon A, Suh M, Cheon GJ, Lee DS, Kim EE, Chung JK

Renal metastasis of thyroid cancer is extremely rare. We report the case of a 62-year-old woman with Hürthle cell thyroid cancer (HCTC) with lungs, bones, and bilateral kidneys metastases. The...
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In Vitro Radionuclide Therapy and In Vivo Scintigraphic Imaging of Alpha-Fetoprotein-Producing Hepatocellular Carcinoma by Targeted Sodium Iodide Symporter Gene Expression

Kim KI, Lee YJ, Lee TS, Song I, Cheon GJ, Lim SM, Chung JK, Kang JH

  • KMID: 1427701
  • Nucl Med Mol Imaging.
  • 2013 Mar;47(1):1-8.
PURPOSE: This study aimed to develop a gene expression targeting method for specific imaging and therapy of alpha-fetoprotein (AFP)-producing hepatocellular carcinoma (HCC) cells, using an adenovirus vector containing the human...
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Radioiodine Therapy of Liver Cancer Cell Following Tissue Specific Sodium Iodide Symporter Gene Transfer and Assessment of Therapeutic Efficacy with Optical Imaging

Jang BK, Lee YL, Lee YJ, Ahn SJ, Ryu MJ, Yoon SM, Lee SW, Yoo J, Cho JY, Lee J, Ahn BC

  • KMID: 2051951
  • Nucl Med Mol Imaging.
  • 2008 Oct;42(5):383-393.
PURPOSE: Cancer specific killing can be achieved by therapeutic gene activated by cancer specific promotor. Expression of sodium iodide symporter (NIS) gene causes transportation and concentration ofiodide into the cell,...
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