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Role of NEAT1/MiR-9-5p/SLC26A2 Pathway on Human Airway Smooth Muscle Cell

Wang X, Xu R, Chi D, Dai C, Sheng M

Purpose: Asthma is a serious inflammatory disease of the respiratory system in which airway smooth muscle cells (ASMCs) play a key role. This study aimed to investigate the expression of...
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Impaired Colonic Contractility and Intestinal Permeability in Symptomatic Uncomplicated Diverticular Disease

Altomare A, Gori M, Cocca S, Carotti S, Francesconi M, Ribolsi M, Emerenziani S, Perrone G, Morini S, Cicala M, Guarino MPL

  • KMID: 2514687
  • J Neurogastroenterol Motil.
  • 2021 Apr;27(2):292-301.
  • doi: 10.5056/jnm20110
Background/Aims Impaired intestinal motility seems to play a crucial role in symptomatic uncomplicated diverticular disease (SUDD), although the mechanism is not clear. The aim of the present study is to explore...
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Modulation of Vascular Smooth Muscle Cell Phenotype by High Mobility Group AT-Hook 1

Jung Y, Lee HS, Ha JM, Jin SY, Kum HJ, Vafaeinik F, Ha HK, Song SH, Kim CD, Bae SS

Objective: The purpose of this study is to examine the effect of high mobility group AT-hook 1 (HMGA1) on the phenotyptic change of vascular smooth muscle cells (VSMCs). Methods: Gene silencing...
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The proper concentrations of dextrose and lidocaine in regenerative injection therapy: in vitro study

Woo MS, Park J, Ok SH, Park M, Sohn JT, Cho MS, Shin IW, Kim YA

Background: Prolotherapy is a proliferation therapy as an alternative medicine. A combination of dextrose solution and lidocaine is usually used in prolotherapy. The concentrations of dextrose and lidocaine used in...
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Gamma-aminobutyric acid-salt attenuated high cholesterol/high salt diet induced hypertension in mice

Son M, Oh S, Lee HS, Choi J, Lee BJ, Park JH, Park CH, Son KH, Byun K

Excessive salt intake induces hypertension, but several gamma-aminobutyric acid (GABA) supplements have been shown to reduce blood pressure. GABAsalt, a fermented salt by L. brevis BJ20 containing GABA was prepared...
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Disseminated Peritoneal Leiomyomatosis with Atypical Features and Comorbid Uterine STUMP: a Case Report and Review of the Literature

Ryu Kh, Lee EJ, Chang YW, Hong SS, Hwang Jy, Oh Es, Nam BD, Choi Ih, Lee HP

Disseminated peritoneal leiomyomatosis (DPL) is a very rare benign disease, characterized by multiple solid subperitoneal or peritoneal smooth muscle nodules in abdominopelvic cavity and malignant transformation is extremely rare. Also,...
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Activation of AMPK by Telmisartan Decreases Basal and PDGF-stimulated VSMC Proliferation via Inhibiting the mTOR/p70S6K Signaling Axis

Hwang YJ, Park JH, Cho DH

Background: Telmisartan, an angiotensin II type 1 receptor blocker (ARB), is widely used to treat hypertension by blocking the renin-angiotensin-aldosterone system. Although abnormal proliferation of vascular smooth muscle cells (VSMCs)...
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Incorporation of Smooth Muscle Cells Derived from HumanAdipose Stem Cells on Poly(Lactic-co-Glycolic Acid) Scaffoldfor the Reconstruction of Subtotally Resected Urinary Bladderin Athymic Rats

Salem SA, Rashidbenam Z, Jasman MH, Ho CCK, Sagap I, Singh R, Yusof MR, Zainuddin ZM, Idrus RBH, Ng MH

BACKGROUND: The urinary tract can be affected by both congenital abnormalities as well as acquired disorders, such ascancer, trauma, infection, inflammation, and iatrogenic injuries, all of which may lead to...
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Inhibition of Smooth Muscle Cell Proliferation and Migration by a Talin Modulator Attenuates Neointimal Formation after Femoral Arterial Injury

Lim IR, Kim C, Jung JW, Kim JH, Hong SJ

Background and Objectives: Vascular smooth muscle cell (SMC) proliferation and migration play a critical role in neointimal formation. Focal adhesion is involved in cell proliferation and migration, and talin is...
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Regulatory Effects of O-GlcNAcylation in Vascular Smooth Muscle Cells on Diabetic Vasculopathy

Byon CH, Kim SW

Vascular complications from uncontrolled hyperglycemia are the leading cause of death in patients with diabetes mellitus. Previous reports have shown a strong correlation between hyperglycemia and vascular calcification, which increases...
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Cumulative Effects of Constituents from the Mushroom Calvatia nipponica on the Contractility of Penile Corpus Cavernosum Smooth Muscle

Lee S, Kim MJ, Lee BS, Ryoo R, Kim HK, Kim KH

Calvatia nipponica, a puffball mushroom (Agaricaceae), is thought to be an aphrodisiac, as this mushroom is traditionally known to improve sexual function in males. As part of the systematic study...
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Effects of 17β-Estradiol on the Plasminogen Activator System in Vascular Smooth Muscle Cells Treated with Lysophophatidylcholine

Yoon BK, Kang YH, Oh WJ, Lee DY, Kim DK, Kessel B, Kang CD

Objectives: When administered soon after menopause, hormone therapy can prevent coronary heart diseases in women. To explore the mechanism underlying the cardioprotective actions of estrogen, we investigated the effects of...
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17β-Estradiol Inhibits Lysophosphatidylcholine-Induced Apoptosis in Cultured Vascular Smooth Muscle Cells

Yoon BK, Kang YH, Oh WJ, Roh CR, Kim DK, Kang CD

Objectives: Coronary heart disease (CHD) risk increases in women after menopause, but menopausal hormone therapy (MHT) helps prevent CHD if started early after menopause. To explore the mechanism underlying the...
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Computed Tomography-Based Preoperative Simulation System for Pedicle Screw Fixation in Spinal Surgery

Wi W, Park SM, Shin BS

Background: A preoperative planning system facilitates improving surgical outcomes that depend on the experience of the surgeons, thanks to real-time interaction between the system and surgeons. It visualizes intermediate surgical...
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Dendropanax morbifera Extract Inhibits Intimal Hyperplasia in Balloon-Injured Rat Carotid Arteries by Modulating Phenotypic Changes in Vascular Smooth Muscle Cells

Lim L, Jo J, Yoon SP, Jang I, Ki YJ, Choi DH, Song H

The plant Dendropanax morbifera Léveille is effective folk medicines for the treatment of several conditions, such as infectious diseases, skin diseases, and other illnesses. Although the inhibitory effects of D....
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The function of zinc in the primary vascular smooth muscle cell proliferation in rats

Cho YE, Kwun IS

Purpose: The vascular smooth muscle cells (VSMCs) in mature animals have implicated to play a major role in the progression of cardiovascular diseases such as atherosclerosis. This study aimed at...
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Clinically relevant concentrations of dexmedetomidine may reduce oxytocin-induced myometrium contractions in pregnant rats

Kim DJ, Ki YJ, Jang BH, Kim S, Kim SH, Jung KT

Background: Recently, there have been some trials to use dexmedetomidine in the obstetric field but concerns regarding the drug include changes in uterine contractions after labor. We aimed to evaluate...
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Decreased inward rectifier and voltage-gated K⁺ currents of the right septal coronary artery smooth muscle cells in pulmonary arterial hypertensive rats

Kim SE, Yin MZ, Kim HJ, Vorn R, Yoo HY, Kim SJ

In vascular smooth muscle, K⁺ channels, such as voltage-gated K⁺ channels (Kv), inward-rectifier K⁺ channels (Kir), and big-conductance Ca²⁺-activated K⁺ channels (BK(Ca)), establish a hyperpolarized membrane potential and counterbalance the...
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Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway

Kim SG, Sung JY, Kim JR, Choi HC

Aging is one of the risk factors for the development of cardiovascular diseases. During the progression of cellular senescence, cells enter a state of irreversible growth arrest and display resistance...
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Anti-malarial Drugs Reduce Vascular Smooth Muscle Cell Proliferation via Activation of AMPK and Inhibition of Smad3 Signaling

Lee H, Han JH, Kim S, Kim S, Cho DH, Woo CH

OBJECTIVE: The aim of this study was to investigate the effects of 2 anti-malarial drugs, chloroquine (CQ) and hydroxychloroquine (HCQ), on inhibition of vascular smooth muscle cell (VSMC) proliferation both...
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