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Skin Barrier Dysfunction in the Scalp, Nails, and Lips in Patients with Atopic Dermatitis

Lee CY, Jeong KH, Shin MK

  • KMID: 2506583
  • Korean J Dermatol.
  • 2020 Sep;58(8):525-529.
Background: Atopic dermatitis is a chronic, inflammatory disease affecting the skin including the scalp, nails, and lips. One of the main pathogenesis of atopic dermatitis is skin barrier impairment. Transepidermal...
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The Efficacy and Safety of Zinc-alpha-2 Glycoprotein (ZAG) Containing Moisturizer in Atopic Dermatitis

Kim SM, Chu H, Lee KH, Park CO

  • KMID: 2508886
  • Korean J Dermatol.
  • 2020 Nov;58(9):575-582.
Background: Patients with atopic dermatitis (AD) are vulnerable to xerosis due to impaired skin barrier function, which makes moisturizing essential. Recently, zinc-alpha-2 glycoprotein (ZAG) has appeared to modulate the skin...
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Enrichment of Short-Chain Ceramides and Free Fatty Acids in the Skin Epidermis, Liver, and Kidneys of db/db Mice, a Type 2 Diabetes Mellitus Model

Kim M, Jeong H, Lee B, Cho Y, Yoon WK, Cho A, Kwon G, Nam KT, Ha H, Lim KM

Patients with diabetes mellitus (DM) often suffer from diverse skin disorders, which might be attributable to skin barrier dysfunction. To explore the role of lipid alterations in the epidermis in...
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Activated Leukocyte Cell Adhesion Molecule Modulates Th2 Immune Response in Atopic Dermatitis

Oh MS, Hong JY, Kim MN, Kwak EJ, Kim SY, Kim EG, Lee KE, Kim YS, Jee HM, Kim SH, Sol IS, Park CO, Kim KW, Sohn MH

PURPOSE: Activated leukocyte cell adhesion molecule (ALCAM), a member of the immunoglobulin superfamily, is highly expressed on dendritic cells. ALCAM and its receptor CD6 are co-stimulatory molecules in the immunological...
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Comparison of Clinical Features according to FLG Mutation in Korean Atopic Dermatitis Patients

Lee H, Wang HY, Lee H, Choi EH

  • KMID: 2457686
  • Korean J Dermatol.
  • 2019 Aug;57(7):363-370.
BACKGROUND: Mutation in the gene encoding filaggrin (FLG) is a major predisposing factor for atopic dermatitis (AD), in association with distinct features such as increased allergic sensitization, higher severity, and...
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A Clinical Study on the Association between Sensitive Skin and Acne in Patients with Acne

Choi W, Myung KB, Hahn HJ, Cheong SH

  • KMID: 2457685
  • Korean J Dermatol.
  • 2019 Aug;57(7):355-362.
BACKGROUND: Acne is a common inflammatory skin disease that involves the seborrheic area, developing not only in adolescence but also in adulthood. Abnormal epidermal barrier function in acne is reported...
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Clinical Characteristics and Genetic Variations in Early-Onset Atopic Dermatitis Patients

Kim BJ, Wang HY, Lee H, Lee SY, Hong SJ, Choi EH

BACKGROUND: Hereditary factors contribute to atopic dermatitis (AD) development. We developed the reverse blot hybridization assay (REBA) kit to simultaneously detect variations in skin barrier- and immune response-related genes prevalent...
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Differences in Genetic Variations Between Treatable and Recalcitrant Atopic Dermatitis in Korean

Jun M, Wang HY, Lee S, Choi E, Lee H, Choi EH

PURPOSE: Variations in barrier- or immune response-related genes are closely related to the development of atopic dermatitis (AD). This study was designed to identify genetic variations and clinical features to...
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Kinetin Improves Barrier Function of the Skin by Modulating Keratinocyte Differentiation Markers

An S, Cha HJ, Ko JM, Han H, Kim SY, Kim KS, Lee SJ, An IS, Kim S, Youn HJ, Ahn KJ, Kim SY

BACKGROUND: Kinetin is a plant hormone that regulates growth and differentiation. Keratinocytes, the basic building blocks of the epidermis, function in maintaining the skin barrier. OBJECTIVE: We examined whether kinetin induces...
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Skin Barrier Recovery by Protease-Activated Receptor-2 Antagonist Lobaric Acid

Joo YA, Chung H, Yoon S, Park JI, Lee JE, Myung CH, Hwang JS

Atopic dermatitis (AD) results from gene and environment interactions that lead to a range of immunological abnormalities and breakdown of the skin barrier. Protease-activated receptor 2 (PAR2) belongs to a...
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Skin Barrier Function Is Not Impaired and Kallikrein 7 Gene Polymorphism Is Frequently Observed in Korean X-linked Ichthyosis Patients Diagnosed by Fluorescence in Situ Hybridization and Array Comparative Genomic Hybridization

Lee NR, Yoon NY, Jung M, Kim JY, Seo SJ, Wang HY, Lee H, Sohn YB, Choi EH

X-linked ichthyosis (XLI) is a recessively inherited ichthyosis. Skin barrier function of XLI patients reported in Western countries presented minimally abnormal or normal. Here, we evaluated the skin barrier properties...
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Application of Topical Acids Improves Atopic Dermatitis in Murine Model by Enhancement of Skin Barrier Functions Regardless of the Origin of Acids

Lee NR, Lee HJ, Yoon NY, Kim D, Jung M, Choi EH

BACKGROUND: The acidic pH of the stratum corneum (SC) is important for epidermal permeability barrier homeostasis. Acidification of the skin surface has been suggested as a therapeutic strategy for skin...
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The Effect of Mometasone Furoate Cream on Skin Barrier Function in Patients with Allergic Contact Dermatitis

So BJ, Park JB, Chun SH, Son SW

  • KMID: 2246081
  • Korean J Dermatol.
  • 2015 Jun;53(5):347-350.
BACKGROUND: It is unclear how the usage of topical steroid agents affects skin barrier function. OBJECTIVE: In order to follow up on previous research into this topic, we sought to investigate...
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Epidermal Permeability Barrier Defects and Barrier Repair Therapy in Atopic Dermatitis

Lee HJ, Lee SH

Atopic dermatitis (AD) is a multifactorial inflammatory skin disease perpetuated by gene-environmental interactions and which is characterized by genetic barrier defects and allergic inflammation. Recent studies demonstrate an important role...
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Pathogenesis of atopic dermatitis

Choi EH, Yoon NY

Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease with severe pruritus, and the first step of atopic march since it often precedes asthma or allergic rhinitis. Since its...
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Wet-work Exposure: A Main Risk Factor for Occupational Hand Dermatitis

Behroozy A, Keegel TG

Wet-work can be defined as activities where workers have to immerse their hands in liquids for >2 hours per shift, or wear waterproof (occlusive) gloves for a corresponding amount of...
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Stimulation of keratinocyte differentiation by extract of combined medicinal plant

Li XM, Choi DK, Lim SK, Ahn IS, Kim DI, Piao YJ, Kim CD, Lee JH

Skin is the outermost organ and acts as a barrier between the organism and environment. Skin protects the organism from environmental insults, such as chemicals, pathogens, and UV light. Much...
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Mutations in the Filaggrin are Predisposing Factor in Korean Children With Atopic Dermatitis

Yu HS, Kang MJ, Jung YH, Kim HY, Seo JH, Kim YJ, Lee SH, Kim HJ, Kwon JW, Kim BJ, Yu J, Hong SJ

PURPOSE: Filaggrin (FLG) is a key protein that facilitates the terminal differentiation of the epidermis and the formation of the skin barrier. Recent studies showed that atopic dermatitis (AD) associates...
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Clinical use of a ceramide-based moisturizer for treating dogs with atopic dermatitis

Jung JY, Nam EH, Park SH, Han SH, Hwang CY

In humans, skin barrier dysfunction is thought to be responsible for enhanced penetration of allergens. Similar to conditions seen in humans, canine atopic dermatitis (CAD) is characterized by derangement of...
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Atopic dermatitis and skin barrier dysfunction

Kim H, Shin JU, Lee KH

Atopic dermatitis is a chronic relapsing eczematous dermatosis, which usually starts in childhood, and various causes are intricately associated with the development of the disease. Recently, various abnormalities in barrier...
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