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Prolonged oral sildenafil use-induced Mondor disease: a case report

Chung HS, Mun YH

Penile Mondor disease (MD) is a palpable, painful, subcutaneous induration caused by superficial dorsal penile vein thrombosis. We report a case of penile MD that was suspected to be related...
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The Frequency-Dependence of Pre- and Postganglionic Nerve Stimulation of Pig and Rat Bladder

Kitney D, Crook J, Chakrabarty B, Kanai A, Vahabi B, Lovick T, Fry C

Purpose: The urinary bladder generates phasic contractions via action potentials generated in pre- and then postganglionic neurons. Whilst the frequency-dependence of postganglionic neurons to generate contractions has been quantified, the...
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Subarachnoid Hemorrhage Caused by Aneurysm Rupture after Ingestion of Sildenafil

Song YM

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The effect of two phosphodiesterase inhibitors on bone healing in mandibular fractures (animal study in rats)

MalekiGorji M, Golestaneh A, Razavi SM

Objectives: Despite advances in maxillofacial surgery, impaired bone healing remains a concern for surgical teams. Many studies have evaluated the effects of sildenafil and pentoxifylline on bone healing. However, their...
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A Case Report of Cyanopsia after Taking Sildenafil

Lee CH, Yoon JS, Ji E

The emergence of phosphodiesterase (PDE) 5 inhibitors gave rise to the solution for erectile dysfunction, starting with the development of sildenafil. Although their efficacy in treating erectile dysfunction has been...
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No Causal Link between Phosphodiesterase Type 5 Inhibition and Melanoma

Wang JZ, Le S, Alexanian , Boddu S, Merleev A, Marusina A, Maverakis

PURPOSE: To examine the association between phosphodiesterase type 5 (PDE5) inhibitor use and melanoma by 1) conducting a systematic review of observational studies; and 2) determining if low PDE5A gene...
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A Case of Sexual Enhancer Induced Fixed Drug Eruption

Lee SK, Kim DJ, Suh JH, Kim MS, Lee UH

  • KMID: 2436688
  • Korean J Dermatol.
  • 2018 May;56(4):269-272.
Fixed drug eruption is a commonly reported mucocutaneous drug eruption. A 61-year-old male presented to our clinic with a complaint of an itchy round erythematous patch on the left hand...
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A Case of a Visual Field Defect with Optical Coherence Tomography Changes after Sildenafil Citrate Overdose

Park HS, Yang JY, Lee J

PURPOSE: A case of a transient visual field defect and a change in spectral-domain optical coherence tomography (SD-OCT) after an overdose of sildenafil citrate is described. CASE SUMMARY: A 67-year-old male...
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Large Atrial Septal Defect Closure in a Patient with Severe Pulmonary Arterial Hypertension

Supomo S, Hartopo AB, Anggrahini DW, Darmawan H, Dinarti LK

Patients with an atrial septal defect (ASD) and severe pulmonary arterial hypertension (PAH) are considered ineligible for defect closure surgery because of the risk of right ventricular decompensation and death...
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Comparison of pharmacokinetic characteristics of sildenafil citrate chewable tablets and film-coated tablets in healthy male subjects

Yoo H, Cho SM, Choi YW, Lee HJ, Kwon JH, Kim SW, Kim JW, Lee S, Hong JH

UI14SDF100CW is a chewable tablet of sildenafil citrate, which was developed to improve compliance through convenience of administration. The purpose of this study was to compare the pharmacokinetic (PK) properties...
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A Rare Case of Viagra Induced Toxic Encephalopathy

Jeong SY, Jeon SJ, Kim YR, Choi SS, Kwak HS

Viagra has been prescribed worldwide to treat men with erectile dysfunction. Clinical trials have shown that Viagra may cause various kinds of adverse effects include some central nervous system (CNS)...
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The effect of sildenafil on right ventricular remodeling in a rat model of monocrotaline-induced right ventricular failure

Bae HK, Lee H, Kim KC, Hong YM

PURPOSE: Pulmonary arterial hypertension (PAH) leads to right ventricular failure (RVF) as well as an increase in pulmonary vascular resistance. Our purpose was to study the effect of sildenafil on...
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Population pharmacokinetics and inter-laboratory variability of sildenafil and its metabolite after oral administration in Korean healthy male volunteers

Youn S, Park WS, Park GJ, Jang DY, Bae SH, Han S, Yim DS

This study was to clarify population pharmacokinetics (PK) of sildenafil and its metabolite, N-desmethyl sildenafil (NDS) in Korean healthy male population using a pooled data from multiple clinical trials in...
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Sildenafil Ameliorates Advanced Glycation End Products-Induced Mitochondrial Dysfunction in HT-22 Hippocampal Neuronal Cells

Sung SK, Woo JS, Kim YH, Son DW, Lee SW, Song GS

OBJECTIVE: Accumulation of advanced glycation end-products (AGE) and mitochondrial glycation is importantly implicated in the pathological changes of the brain associated with diabetic complications, Alzheimer disease, and aging. The present...
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Flibanserin for Treating Hypoactive Sexual Desire Disorder

Sang JH, Kim TH, Kim SA

There have been several products developed for male sexual dysfunction. However, developing agents for female sexual dysfunction is lagging behind for various reasons. Sildenafil citrate (Viagra) and Tadalafil (Cialis), which...
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A Case of Transient Color Anomaly and Persistent Visual Field Defect after Sildenafil Citrate Overdose

Kim P, Kim SY

PURPOSE: Sildenafil citrate, is an oral tablet demonstrating efficacy for maintaining an erection in males with erectile dysfunction by inhibiting phosphodiesterase type 5 (PDE5). In the present study, we report...
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Comparison of Prostaglandin E1 and Sildenafil Citrate Administration on Skin Flap Survival in Rats

Choi JA, Lee KC, Kim MS, Kim SK

BACKGROUND: Alprostadil and sildenafil are known vasodilators used independently to improve flap survival in animal models. In this study, we investigate whether these agents act synergistically to decrease flap necrosis...
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Diffuse Alveolar Hemorrhage Confirmed by Bronchoalveolar Lavage in a Patient with Hemoptysis after Sildenafil Use for Erectile Dysfunction

Moon KM, Jung SY, Han MS, Cho Y, Rah YM, Kim JW

A 81-year-old man was referred for respiratory failure by emergency medical technicians. He admitted at intensive care unit for ventilator treatment. Several hours before admission, he took sildenafil 100 mg...
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Aggravation of Hepatopulmonary Syndrome after Sildenafil Treatment in a Patient with Coexisting Portopulmonary Hypertension

Chung S, Lee K, Chang SA, Kim DK

Hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PPHTN) are complications of portal hypertension and cirrhosis. Their pathophysiological mechanisms clearly differ. HPS is characterized by a defect in arterial oxygenation induced by...
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Sildenafil Inhibits Advanced Glycation End Products-induced sFlt-1 Release Through Upregulation of Heme Oxygenase-1

Jeong JH, Kim HG, Choi OH

OBJECTIVES: We examined the effect of sildenafil citrate on advanced glycation end products (AGEs)-induced soluble fms-like tyrosine kinase 1 (sFlt-1) release in JEG-3 choriocarcinoma cells. METHODS: Cells were incubated with control...
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