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Reverse vaccinology approach for the identification and characterization of outer membrane proteins of Shigella flexneri as potential cellular- and antibody-dependent vaccine candidates

Leow CY, Kazi A, Hisyam Ismail CMK, Chuah C, Lim BH, Leow CH, Banga Singh KK

PURPOSE: In the developing world, bacillary dysentery is one of the most common communicable diarrheal infections. There are approximately 169 million cases of shigellosis reported worldwide. The disease is transmitted...
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Multiplex PCR Based Epidemiological Study for the Causes of Acute Diarrheal Disease in Adults Living in Jeju Island

Lee K, Kim DS, Chong MS

BACKGROUND: We attempted to determine the characteristics of diarrheal pathogens according to species, seasonal variations, and patient age using multiplex PCR for the epidemiologic study of diarrheal disease in Jeju...
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Genotypic Diversity of Multidrug Resistant Shigella species from Iran

Zamanlou S, Rezaee MA, Aghazadeh , Ghotaslou , Nave HH, Khalili Y

BACKGROUND: In many developing countries, shigellosis is endemic and also occurs in epidemics and treatment of multidrug-resistant (MDR) isolates are important. The aims of this study were to determine the...
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Functional Prediction of Hypothetical Proteins from Shigella flexneri and Validation of the Predicted Models by Using ROC Curve Analysis

Gazi MA, Mahmud S, Fahim SM, Kibria MG, Palit P, Islam MR, Rashid H, Das S, Mahfuz M, Ahmeed T

Shigella spp. constitutes some of the key pathogens responsible for the global burden of diarrhoeal disease. With over 164 million reported cases per annum, shigellosis accounts for 1.1 million deaths...
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Anti-Bacterial Effect of Lactobacillus rhamnosus Cell-Free Supernatant Possessing Lysozyme Activity Against Pathogenic Bacteria

Lee J, Lim H, Kim M

Recently, there has been a growing demand for natural preservatives because of increased consumer interest in health. In this study, we produced Lactobacillus rhamnosus cell-free supernatant (LCFS) and evaluated and...
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Infection of human intestinal epithelial cells by invasive bacteria activates NF-κB and increases ICAM-1 expression through NOD1

Shin WG, Park BJ, Lee SJ, Kim JG

BACKGROUND/AIMS: Nucleotide-binding oligomerization domain 1 (NOD1) is required for primary intestinal epithelial cells (IECs) to respond to natural mucopeptides secreted by gram-negative bacteria. Infection of human IECs with invasive bacteria...
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Characterization of Extended-Spectrum β-Lactamase Genes of Shigella flexneri Isolates With Fosfomycin Resistance From Patients in China

Liu Y, Cheng Y, Yang H, Hu L, Cheng J, Ye Y, Li J

BACKGROUND: The emergence of fosfomycin resistance and extended-spectrum β-lactamase (ESBL) genes is a serious threat to public health and a new challenge in shigellosis treatment. The purpose of this study...
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Profiling of Virulence-associated Factors in Shigella Species Isolated from Acute Pediatric Diarrheal Samples in Tehran, Iran

Yaghoubi S, Ranjbar R, Dallal MM, Fard SY, Shirazi MH, Mahmoudi M

OBJECTIVES: The genus Shigella comprises the most infectious and diarrheagenic bacteria causing severe diseases, mostly in children under five years of age. This study aimed to detect nine virulence genes...
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Clinical Characteristics and Ultrasonographic Findings of Acute Bacterial Enterocolitis in Children

Chun P, Lim TJ, Hwang EH, Mun SW, Lee YJ, Park JH

PURPOSE: This study clarified the bacterial pathogens currently causing acute infectious enterocolitis (AIE) in children and evaluated the clinical characteristics and ultrasonographic findings according to the different pathogens. METHODS: Medical records...
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Genome Sequencing Analysis of Atypical Shigella flexneri Isolated in Korea

Kim NO, Na HY, Jung SM, Chung GT, Kawk HS, Hong S

OBJECTIVES: An atypical Shigella flexneri strain with a plural agglutination pattern [i.e., reacting not only with serum samples containing type antigen II but also with serum samples containing group antigens...
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The clinical features and infectious etiologies of acute diarrhea in immunocompromised hosts

Lee JY, Kim YN, Kim N, Cho KS, Park JY

OBJECTIVES: The acute diarrhea is a common complaint among immunocompromised hosts, and may cause life threatening event. The infectious etiologies vary depending on virus, bacteria, and parasites. The most common...
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Intestinal Parasitic Infections and Environmental Water Contamination in a Rural Village of Northern Lao PDR

Ribas A, Jollivet C, Morand S, Thongmalayvong B, Somphavong S, Siew CC, Ting PJ, Suputtamongkol S, Saensombath V, Sanguankiat S, Tan BH, Paboriboune P, Akkhavong , Chaisiri K

A field survey studying intestinal parasites in humans and microbial pathogen contamination at environment was performed in a Laotian rural village to identify potential risks for disease outbreaks. A parasitological...
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High Frequency of Enteric Protozoan, Viral, and Bacterial Potential Pathogens in Community-Acquired Acute Diarrheal Episodes: Evidence Based on Results of Luminex Gastrointestinal Pathogen Panel Assay

Hawash YA, Ismail KA, Almehmadi

Infectious diarrhea is endemic in most developing countries. We aimed to investigate the protozoan, viral, and bacterial causes of acute diarrhea in Taif, Saudi Arabia. A cross-sectional prospective 1-year study...
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Long-term Clinical Course of Post-infectious Irritable Bowel Syndrome After Shigellosis: A 10-year Follow-up Study

Youn YH, Kim HC, Lim HC, Park JJ, Kim JH, Park H

  • KMID: 2327955
  • J Neurogastroenterol Motil.
  • 2016 Jul;22(3):490-496.
  • doi: 10.5056/jnm15157
BACKGROUND/AIMS: A limited number of studies are available regarding the long-term natural history of post-infectious irritable bowel syndrome (PI-IBS). We aimed to investigate the long-term clinical course of PI-IBS. METHODS: A...
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Clinical and microbiologic characteristics of vulvovaginitis in Korean prepubertal girls, 2009-2014: a single center experience

Kim H, Chai SM, Ahn EH, Lee MH

OBJECTIVE: To update information on the clinical and microbiologic characteristics of pediatric vulvovaginitis in Korean prepubertal girls. METHODS: A total of 120 girls (aged 0 to 9 years) with culture-confirmed pediatric...
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Prevalence of Bacteria in the Nationwide Survey of Stool Culture Performed in 2015, Korea.

Choi WH, Byun JH, Kim S

BACKGROUND: The spectrum of bacteria causing diarrhea is highly affected by geographic area, sanitation, travel, food consumption, and previous antibiotic use. A nationwide databank for stool cultures is undeveloped. The...
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Infection of Extended-Spectrum β-Lactamase Producing Shigella flexneri in Children Attending a Childcare Center in Korea

Nam EW, Lee KS, Kim J, Yoo CK

Shigella is a common cause of bacterial enteritis worldwide. Shigella sonnei accounts for 90% of Shigella infections and Shigella flexneri is rarely reported in Korea. Although the incidence of Shigella...
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rpoB gene sequencing for phylogenetic analysis of avian pathogenic Escherichia coli

Kwon HJ, Seong WJ, Kim TE, Won YJ, Kim JH

The present study was conducted to determine the full rpoB and eight house-keeping gene sequences of 78 and 35, respectively, avian pathogenic E. coli (APEC) strains. Phylogenetic comparison with 66...
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Evaluation of the Impact of Automated Specimen Inoculation, Using Previ Isola, on the Quality of and Technical Time for Stool Cultures

Mischnik A, Trampe M, Zimmermann S

BACKGROUND: This study was designed as a quasi-experiment to evaluate automatic inoculation of fecal specimens, using the automated specimen inoculator Previ Isola (bioMerieux, France). METHODS: We evaluated the quality of cultures,...
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Identification of Bacterial Flora on Cellular Phones of Dentists

Kwon YW, Lee SY

  • KMID: 1727431
  • Int J Oral Biol.
  • 2014 Sep;39(3):137-143.
Dental professionals are repeatedly exposed to many microorganisms present in both blood and saliva. Thus, dental professionals are at a greater risk of acquiring and spreading infections, and the implementation...
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