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Catalpol Inhibits Tregs-to-Th17 Cell Transdifferentiation by Up-Regulating Let-7g-5p to Reduce STAT3 Protein Levels

Di Y, Zhang M, Chen Y, Sun R, Shen M, Tian F, Yang P, Qian F, Zhou L

Purpose: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, and Th17 cells are key factors in the pathogenesis of human inflammatory conditions, such as RA. Catalpol (CAT), a component...
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CBX7 Rejuvenates Late Passage Dental Pulp Stem Cells by Maintaining Stemness and Pro-angiogenic Ability

Wu Y, Li B, Yu D, Zhou Z, Shen M, Jiang F

BACKGROUND: Ever-growing tissue regeneration causes pressing need for large population of stem cells. However, extensive cell expansion eventually leads to impaired regenerative potentials. In this study, chromobox protein homolog 7...
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The Association between Dairy Intake and Breast Cancer in Western and Asian Populations: A Systematic Review and Meta-Analysis

Zang J, Shen M, Du S, Chen T, Zou S

PURPOSE: To date, studies investigating the association between dairy consumption and breast cancer in women have produced conflicting results. As diet is an important, modifiable factor affecting cancer development, the...
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Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity

Shen M, Zhang L, Lee KM, Vermeulen , Hosgood HD, Li G, Yin S, Rothman N, Chanock S, Smith MT, Lan Q

Benzene, a recognized hematotoxicant and carcinogen, can damage the human immune system. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and benzene hematotoxicity...
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