Skip Navigation
Skip to contents
Results by Year

View Wide

Filter

ARTICLE TYPE

more+
SELECT FILTER
 
Close

PUBLICATION DATE

63 results
Display

The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis

Go S, Kang M, Kwon SP, Jung M, Jeon OH, Kim BS

BACKGROUND Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phenotype (SASP). Senescent cells are often...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Luteolin inhibits H2O2 -induced cellular senescence via modulation of SIRT1 and p53

Zhu RZ, Li BS, Gao SS, Seo JH, Choi BM

Luteolin, a sort of flavonoid, has been reported to be involved in neuroprotective function via suppression of neuroinflammation. In this study, we investigated the protective effect of luteolin against oxidative...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Synergistic Tumoricidal Effects of Alpha-Lipoic Acid and Radiotherapy on Human Breast Cancer Cells via HMGB1

Choi HS, Kim JH, Jang SJ, Yun JW, Kang KM, Jeong H, Ha IB, Jeong BK

Purpose Radiotherapy (RT) is one of main strategies of cancer treatment. However, some cancer cells are resistant to radiation-induced cell death, including apoptosis. Therefore, alternative approaches targeting different anti-tumor mechanisms...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Pathogenesis and prevention of skin aging

Cho S

Background: As global life expectancy increases, an interest in maintaining health and beauty in old age has increased. As a barrier organ, the skin is an ideal model for studying...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Late Passage Cultivation Induces Aged Astrocyte Phenotypes in Rat Primary Cultured Cells

Bang M, Gonzales EL, Shin CY, Kwon KJ

Astrocytes play various important roles such as maintaining brain homeostasis, supporting neurons, and secreting inflammatory mediators to protect the brain cells. In aged subjects, astrocytes show diversely changed phenotypes and...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Culturing at Low Cell Density Delays Cellular Senescence of Human Bone Marrow-Derived Mesenchymal Stem Cells in Long-Term Cultures

Kim SN, Choi B, Lee CJ, Moon JH, Kim MK, Chung E, Song SU

Background and Objectives: Mesenchymal stem cells (MSCs) have immense therapeutic potential for treating intractable and immune diseases. They also have applications in regenerative medicine in which distinct treatments do not...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression

Hwang CY, Han YH, Lee SM, Cho SM, Yu DY, Kwon KS

Background: Sestrin2 (Sesn2) is involved in the maintenance of metabolic homeostasis and aging via modulation of the 5' AMP-activated protein kinase-mammalian target of rapamycin (AMPK-mTOR) pathway. Methods: Wild-type and Sesn2...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Bone Marrow-Derived Mesenchymal Stem Cells Isolated from Patients with Cirrhosis and Healthy Volunteers Show Comparable Characteristics

Lim YL, Eom YW, Park SJ, Hong T, Kang SH, Baik SK, Park KS, Kim MY

Background and Objectives: Autologous or allogeneic bone marrow-derived mesenchymal stem cells (BMSCs) have been applied in clinical trials to treat liver disease. However, only a few studies are comparing the...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Ultraviolet B-induced Senescence Model Using Corneal Fibroblasts and the Anti-aging Effect of Angiogenin

Sung SM, Lee SJ, Lee KW, Kim JC

Purpose: To establish a corneal-fibroblast senescence model induced by ultraviolet B (UVB) exposure and to investigate the anti-senescence effect of angiogenin (ANG). Methods: Fibroblasts were exposed to UVB (1 mJ/cm 2...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Effect of Cyclosporine A-induced Senescence on Cultured Human Corneal Endothelial Cells

Jang YK, Chung TY, Shin YJ

Purpose: To investigate the in vitro effect of cyclosporine A (CsA)-induced senescence on human corneal endothelial cells (HCECs). Methods: HCECs were cultured and incubated with 0-100 µM CsA. Senescence-associated β–galactosidase (SA-β-gal)...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Cellular Senescence in Pterygium

Kim JH, Lee SJ, Lee KW, Kim JC

Purpose: To determine cellular senescence in pterygium by studying the expression of senescence-related markers. Methods: Impression cytology was performed on 28 eyes of 28 patients diagnosed with pterygium or pinguecula from...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Effect of Hydrogen Sulfide on the Oxidative Stress and Senescence inTrabecular Meshwork Cells

Park HJ, Kim YY, Kim JW

Purpose: To investigate the effects of hydrogen sulfide (H2S) on the senescence and oxidative stress of cultured human trabecular meshwork cells (HTMCs). Methods: After inducing oxidative stress with 200 μM hydrogen peroxide...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Cellular Senescence in Arterial Diseases

Shimizu I, Minamino T

Cell-proliferation potency is limited, as cells cannot proceed through the cell cycle continually. Instead, they eventually show an irreversible arrest of proliferation, commonly referred to as cellular senescence. Following the...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Methyl-CpG Binding Protein 2 in Alzheimer Dementia

Kim B, Choi Y, Kim HS, Im HI

Despite decades of research on Alzheimer disease, understanding the complexity of the genetic and molecular interactions involved in its pathogenesis remains far from our grasp. Methyl-CpG Binding Protein 2 (MeCP2)...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes

Bang M, Kim DG, Gonzales E, Kwon KJ, Shin CY

Brain aging is an inevitable process characterized by structural and functional changes and is a major risk factor for neurodegenerative diseases. Most brain aging studies are focused on neurons and...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Angiotensin II Type 1 Receptor Blocker, Fimasartan, Reduces Vascular Smooth Muscle Cell Senescence by Inhibiting the CYR61 Signaling Pathway

Kim I, Park CS, Lee HY

BACKGROUND AND OBJECTIVES: Angiotensin II (Ang II) has been suggested to accelerate vascular senescence, however the molecular mechanism(s) remain unknown. METHODS: We cultured human coronary artery smooth muscle cells (hCSMCs) and...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes

Bang M, Ryu O, Kim DG, Mabunga DF, Cho KS, Kim Y, Han SH, Kwon KJ, Shin CY

Brain aging induces neuropsychological changes, such as decreased memory capacity, language ability, and attention; and is also associated with neurodegenerative diseases. However, most of the studies on brain aging are...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer

Wang Z, Gao J, Zhou J, Liu H, Xu C

OBJECTIVE: Poly (ADP-ribose) polymerase (PARP) is an important molecule in the early stress response of DNA damage, which is involved in DNA damage repair and cellular senescence. Olaparib, as PARP...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
The role of senescence of bone marrow cells in acute kidney injury

Lee J, Ko YS, Lee HY, Yang J, Oh S, Jo SK, Cho W, Kim MG

BACKGROUND: The prevalence of acute kidney injury (AKI) in elderly patients has grown considerably. Age-associated changes in the immune system can be one of the critical factors determining AKI outcomes....
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Effect of Chronic Benzalkonium Chloride Exposure on Senescence in Trabecular Meshwork Cells

Park J, Lee SJ, Lee KW, Kim JC

PURPOSE: To determine the possible effects of chronic exposure of low dose benzalkonium chloride (BAK) on trabecular meshwork cells, and to characterize the pathways involved in the effects. METHODS: Trabecular meshwork...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close

Go to Top

Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr