- Neuroprotective potential of imatinib in global ischemia-reperfusion-induced cerebral injury: possible role of Janus-activated kinase 2/signal transducer and activator of transcription 3 and connexin 43
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Wang J, Bai T, Wang N, Li H, Guo X
- KMID: 2466565
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):11-18.
- doi: 10.4196/kjpp.2020.24.1.11
The present study was aimed to explore the neuroprotective role of imatinib in global ischemia-reperfusion-induced cerebral injury along with possible mechanisms. Global ischemia was induced in mice by bilateral carotid... -
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- Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad
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Kang JH, Jang YS, Lee HJ, Lee CY, Shin DY, Oh SH
- KMID: 2470020
- Lab Anim Res.
- 2019 Dec;35(4):221-229.
- doi: 10.1186/s42826-019-0030-0
Signal transducer and activator of transcription 3 (STAT3) modulates a variety of genes involved in the regulation of critical functions, including cell proliferation, differentiation, apoptosis, angiogenesis, metastasis, and immunity. For... -
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- Effects of rosmarinic acid on immunoregulatory activity and hepatocellular carcinoma cell apoptosis in H22 tumor-bearing mice
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Cao W, Mo K, Wei S, Lan X, Zhang W, Jiang W
- KMID: 2461043
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):501-508.
- doi: 10.4196/kjpp.2019.23.6.501
Rosmarinic acid (RA) is a natural polyphenolic compound that exists in many medicinal species of Boraginaceae and Lamiaceae. The previous studies have revealed that RA had therapeutic effects on hepatocellular... -
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- Anticancer Activity of Tubulosine through Suppression of Interleukin-6-Induced Janus Kinase 2/Signal Transducer and Activation of Transcription 3 Signaling
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Kim BH, Yi EH, Li YC, Park IC, Park JY, Ye SK
- KMID: 2458858
- J Breast Cancer.
- 2019 Sep;22(3):362-374.
- doi: 10.4048/jbc.2019.22.e34
PURPOSE: The chemical structure of tubulosine has been known since the mid-1960s. However, little is known about its biological and pharmacological functions. The aim of this study was to investigate... -
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- Effect of STAT3 on Lysophosphatidic Acid-Induced Oral Cancer Cell Invasion
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Song ZH, Cho KH, Kim JY, Lee HY
- KMID: 2451792
- J Dent Hyg Sci.
- 2019 Jun;19(2):141-146.
- doi: 10.17135/jdhs.2019.19.2.141
BACKGROUND: Oral cancer has a high incidence worldwide and has been closely associated with smoking, alcohol, and infection by the human papillomavirus. Metastasis is highly important for oral cancer survival.... -
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- Phase I Dose-Finding Study of OPB-111077, a Novel STAT3 Inhibitor, in Patients with Advanced Hepatocellular Carcinoma
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Yoo C, Kang J, Lim HY, Kim JH, Lee MA, Lee KH, Kim TY, Ryoo BY
- KMID: 2464398
- Cancer Res Treat.
- 2019 Apr;51(2):510-518.
- doi: 10.4143/crt.2018.226
PURPOSE: The signal transducer and activator of transcription 3 (STAT3) signaling pathway might be a promising therapeutic target for hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This study was a multicenter, open-label,... -
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- Anti-Migration and Anti-Invasion Effects of Curcumin via Suppression of Fascin Expression in Glioblastoma Cells
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Park KS, Yoon SY, Park SH, Hwang JH
- KMID: 2444791
- Brain Tumor Res Treat.
- 2019 Apr;7(1):16-24.
- doi: 10.14791/btrt.2019.7.e28
BACKGROUND: The natural compound curcumin was known to inhibit migration and invasion of glioblastoma (GBM) cells. Fascin, a kind of actin-binding proteins, is correlated with migration and invasion of GBM... -
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- Porphyromonas gingivalis lipopolysaccharide stimulates vascular smooth muscle cell migration through signal transducer and activator of transcription 3-mediated matrix metalloproteinase-9 expression
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Kim Y, Park JY, Park HJ, Kim MK, Kim YI, Bae SK, Kim HJ, Bae MK
- KMID: 2446937
- Int J Oral Biol.
- 2019 Mar;44(1):20-26.
- doi: 10.11620/IJOB.2019.44.1.20
Periodontal diseases have been associated with the development of cardiovascular diseases. Accumulating evidences have indicated that Porphyromonas gingivalis, a major periodontopathic pathogen, plays a critical role in the pathogenesis of... -
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- MiR-506 Promotes Natural Killer Cell Cytotoxicity against Human Hepatocellular Carcinoma Cells by Targeting STAT3
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Su Z, Ye X, Shang L
- KMID: 2428274
- Yonsei Med J.
- 2019 Jan;60(1):22-29.
- doi: 10.3349/ymj.2019.60.1.22
PURPOSE: It is well documented that natural killer (NK) cytotoxicity against hepatocellular carcinoma (HCC) cells is impaired in HCC, which might account for the failure of anti-tumor immune response. miRNAs... -
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- Aryl Hydrocarbon Receptor Ligands Indoxyl 3-sulfate and Indole-3-carbinol Inhibit FMS-like Tyrosine Kinase 3 Ligand-induced Bone Marrow-derived plasmacytoid Dendritic Cell Differentiation
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Hwang WB, Kim DJ, Oh GS, Park JH
- KMID: 2424201
- Immune Netw.
- 2018 Oct;18(5):e35.
- doi: 10.4110/in.2018.18.e35
Aryl hydrocarbon receptor (AhR) regulates both innate and adaptive immune responses by sensing a variety of small synthetic and natural chemicals, which act as its ligands. AhR, which is expressed... -
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- Effects of Oncostatin M on Invasion of Primary Trophoblasts under Normoxia and Hypoxia Conditions
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Wie JH, Ko HS, Choi SK, Park IY, Kim A, Kim HS, Shin JC
- KMID: 2428915
- Yonsei Med J.
- 2018 Sep;59(7):879-886.
- doi: 10.3349/ymj.2018.59.7.879
PURPOSE: To investigate the effect of oncostatin M (OSM) on protein expression levels and enzymatic activities of matrix metalloprotainase (MMP)-2 and MMP-9 in primary trophoblasts and the invasiveness thereof under... -
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- Cripto Enhances Proliferation and Survival of Mesenchymal Stem Cells by Up-Regulating JAK2/STAT3 Pathway in a GRP78-Dependent Manner
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Yun S, Yun CW, Lee JH, Kim S, Lee SH
- KMID: 2421724
- Biomol Ther.
- 2018 Sep;26(5):464-473.
- doi: 10.4062/biomolther.2017.099
Cripto is a small glycosylphosphatidylinositol-anchored signaling protein that can detach from the anchored membrane and stimulate proliferation, migration, differentiation, vascularization, and angiogenesis. In the present study, we demonstrated that Cripto... -
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- T Cell-Specific Knockout of STAT3 Ameliorates Dextran Sulfate Sodium-Induced Colitis by Reducing the Inflammatory Response
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Kwon SH, Seo EB, Lee SH, Cho CH, Kim SJ, Kim SJ, Kim HR, Ye SK
- KMID: 2419775
- Immune Netw.
- 2018 Aug;18(4):e30.
- doi: 10.4110/in.2018.18.e30
Signal transducer and activator of transcription 3 (STAT3) has a crucial role in various autoimmune disorders including, inflammatory bowel disease (IBD). Our previous study demonstrated that STAT3 activation by IL-6... -
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- STAT3 expression is associated with poor survival in non-elderly adult patients with newly diagnosed multiple myeloma
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Jung SH, Ahn SY, Choi HW, Shin MG, Lee SS, Yang DH, Ahn JS, Kim YK, Kim HJ, Lee JJ
- KMID: 2405066
- Blood Res.
- 2017 Dec;52(4):293-299.
- doi: 10.5045/br.2017.52.4.293
BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is not only a key signaling molecule in the regulation of growth but is also involved in malignant transformation. We investigated... -
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- Functional Defects in Type 3 Innate Lymphoid Cells and Classical Monocytes in a Patient with Hyper-IgE Syndrome
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Chang Y, Kang SY, Kim J, Kang HR, Kim HY
- KMID: 2400640
- Immune Netw.
- 2017 Oct;17(5):352-364.
- doi: 10.4110/in.2017.17.5.352
Hyper-IgE syndrome (HIES) is a very rare primary immune deficiency characterized by elevated serum IgE levels, recurrent bacterial infections, chronic dermatitis, and connective tissue abnormalities. Autosomal dominant (AD) HIES involves... -
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- Heme Oxygenase-1 Induction and Anti-inflammatory Actions of Atractylodes macrocephala and Taraxacum herba Extracts Prevented Colitis and Was More Effective than Sulfasalazine in Preventing Relapse
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Han KH, Park JM, Jeong M, Han YM, Go EJ, Park J, Kim H, Han JG, Kwon O, Hahm KB
- KMID: 2389354
- Gut Liver.
- 2017 Sep;11(5):655-666.
- doi: 10.5009/gnl16496
BACKGROUND/AIMS: In inflammatory bowel disease (IBD), repeated bouts of remission and relapse occur in patients and can impose a risk of colitis-associated cancer. We hypothesized that plant extracts of Atractylodes... -
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- Sinensetin Inhibits Interleukin-6 in Human Mast Cell - 1 Via Signal Transducers and Activators of the Transcription 3 (STAT3) and Nuclear Factor Kappa B (NF-κB) Pathways
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Chae HS, Kim YM, Chin YW
- KMID: 2376491
- Nat Prod Sci.
- 2017 Mar;23(1):1-4.
- doi: 10.20307/nps.2017.23.1.1
Sinensetin, a pentamethoxyflavone, is known to exert various pharmacological activities including anti-angiogenesis, anti-diabetic and anti-inflammatory activities. However, its effects on the human mast cell - 1 (HMC-1) mediated inflammatory mechanism... -
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- Procaine Attenuates Pain Behaviors of Neuropathic Pain Model Rats Possibly via Inhibiting JAK2/STAT3
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Li D, Yan Y, Yu L, Duan Y
- KMID: 2351672
- Biomol Ther.
- 2016 Sep;24(5):489-494.
- doi: 10.4062/biomolther.2016.006
Neuropathic pain (NPP) is the main culprit among chronic pains affecting the normal life of patients. Procaine is a frequently-used local anesthesia with multiple efficacies in various diseases. However, its... -
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- Role of STAT3 Phosphorylation in Ethanol-Mediated Proliferation of Breast Cancer Cells
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Narayanan , Nandabalan SK, Baddireddi LS
- KMID: 2308962
- J Breast Cancer.
- 2016 Jun;19(2):122-132.
- doi: 10.4048/jbc.2016.19.2.122
PURPOSE: In this study, we investigated the molecular mechanism involved in ethanol (EtOH)-mediated proliferation of breast cancer cells. METHODS: EtOH concentration was optimized by studying its effect on cell proliferation in... -
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- STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9
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Ko HS, Park BJ, Choi SK, Kang HK, Kim A, Kim HS, Park IY, Shin JC
- KMID: 2374099
- Yonsei Med J.
- 2016 May;57(3):761-768.
- doi: 10.3349/ymj.2016.57.3.761
PURPOSE: Our previous studies have shown that oncostatin M (OSM) promotes trophoblast invasion activity through increased enzyme activity of matrix metalloproteinase (MMP)-2 and -9. We further investigated OSM-induced intracellular signaling... -
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