- Enhanced Protein Expression of Signal Transducer and Activator of Transcription 3 and Protein Kinase Substrate p36 in Hepatocellular Carcinoma
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Han H, Jang SH, Park CK
- KMID: 1472616
- Korean J Pathol.
- 2009 Oct;43(5):393-399.
- doi: 10.4132/KoreanJPathol.2009.43.5.393
BACKGROUND: Signal transducers and activators of transcription 3 (STAT3) and protein kinase substrate p36 may be involved in cell proliferation, differentiation and growth. METHODS: Immunohistochemistry for STAT3 and p36 was performed... -
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- STAT3, a Poor Survival Predicator, Is Associated with Lymph Node Metastasis from Breast Cancer
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Chen Y, Wang J, Wang X, Liu X, Li H, Lv Q, Zhu J, Wei B, Tang Y
- KMID: 2374543
- J Breast Cancer.
- 2013 Mar;16(1):40-49.
PURPOSE: The aim of this study is to explore signal transducer and activator of transcription 3 (STAT3) expression in breast cancer and to analyze the detailed mechanism that STAT3 contributes... -
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- The Clinical Significance of STAT3 and STAT5 Activation in Renal Cell Carcinoma
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Oh SY, Kim TH, Myung SC, Kim YS
- KMID: 2293481
- Korean J Urol.
- 2004 May;45(5):403-409.
PURPOSE: Cytokines, hormones and growth factors use signal transducers and activators of transcription (STAT) signaling pathways to control various biological responses, including development, differentiation, cell proliferation and survival. STAT3 and... -
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- Effect of STAT3 on Lysophosphatidic Acid-Induced Oral Cancer Cell Invasion
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Song ZH, Cho KH, Kim JY, Lee HY
- KMID: 2451792
- J Dent Hyg Sci.
- 2019 Jun;19(2):141-146.
- doi: 10.17135/jdhs.2019.19.2.141
BACKGROUND: Oral cancer has a high incidence worldwide and has been closely associated with smoking, alcohol, and infection by the human papillomavirus. Metastasis is highly important for oral cancer survival.... -
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- Modulation of the caveolin-3 localization to caveolae and STAT3 to mitochondria by catecholamine-induced cardiac hypertrophy in H9c2 cardiomyoblasts
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Jeong K, Kwon H, Min C, Pak Y
- KMID: 1088597
- Exp Mol Med.
- 2009 Apr;41(4):226-235.
- doi: 10.3858/emm.2009.41.4.025
We investigated the effect of phenylephrine (PE)- and isoproterenol (ISO)-induced cardiac hypertrophy on subcellular localization and expression of caveolin-3 and STAT3 in H9c2 cardiomyoblast cells. Caveolin-3 localization to plasma membrane... -
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- Sinensetin Inhibits Interleukin-6 in Human Mast Cell - 1 Via Signal Transducers and Activators of the Transcription 3 (STAT3) and Nuclear Factor Kappa B (NF-κB) Pathways
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Chae HS, Kim YM, Chin YW
- KMID: 2376491
- Nat Prod Sci.
- 2017 Mar;23(1):1-4.
- doi: 10.20307/nps.2017.23.1.1
Sinensetin, a pentamethoxyflavone, is known to exert various pharmacological activities including anti-angiogenesis, anti-diabetic and anti-inflammatory activities. However, its effects on the human mast cell - 1 (HMC-1) mediated inflammatory mechanism... -
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- STAT3 expression is associated with poor survival in non-elderly adult patients with newly diagnosed multiple myeloma
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Jung SH, Ahn SY, Choi HW, Shin MG, Lee SS, Yang DH, Ahn JS, Kim YK, Kim HJ, Lee JJ
- KMID: 2405066
- Blood Res.
- 2017 Dec;52(4):293-299.
- doi: 10.5045/br.2017.52.4.293
BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is not only a key signaling molecule in the regulation of growth but is also involved in malignant transformation. We investigated... -
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- Activated Rac1 regulates the degradation of IκBα and the nuclear translocation of STAT3–NFκB complexes in starved cancer cells
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Kim SJ, Yoon S
- KMID: 2361518
- Exp Mol Med.
- 2016 May;48(5):e231.
- doi: 10.1038/emm.2016.17
In several human tumors, signal transducer and activator of transcription 3 (STAT3) and nuclear factor κB (NFκB) are activated and interact; how these STAT3–NFκB complexes are transported to the nucleus... -
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- Withaferin-A Inhibits Colon Cancer Cell Growth by Blocking STAT3 Transcriptional Activity
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Choi BY, Kim BW
- KMID: 2380869
- J Cancer Prev.
- 2015 Sep;20(3):185-192.
- doi: 10.15430/JCP.2015.20.3.185
BACKGROUND: Withania somnifera (known as Ashwagandha) is a medicinal plant used in the ayurvedic medicines in India. Withaferin-A, a withanolide derived from the leaf extract of W. somnifera, has been... -
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- Porphyromonas gingivalis lipopolysaccharide stimulates vascular smooth muscle cell migration through signal transducer and activator of transcription 3-mediated matrix metalloproteinase-9 expression
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Kim Y, Park JY, Park HJ, Kim MK, Kim YI, Bae SK, Kim HJ, Bae MK
- KMID: 2446937
- Int J Oral Biol.
- 2019 Mar;44(1):20-26.
- doi: 10.11620/IJOB.2019.44.1.20
Periodontal diseases have been associated with the development of cardiovascular diseases. Accumulating evidences have indicated that Porphyromonas gingivalis, a major periodontopathic pathogen, plays a critical role in the pathogenesis of... -
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- Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad
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Kang JH, Jang YS, Lee HJ, Lee CY, Shin DY, Oh SH
- KMID: 2470020
- Lab Anim Res.
- 2019 Dec;35(4):221-229.
- doi: 10.1186/s42826-019-0030-0
Signal transducer and activator of transcription 3 (STAT3) modulates a variety of genes involved in the regulation of critical functions, including cell proliferation, differentiation, apoptosis, angiogenesis, metastasis, and immunity. For... -
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- Anti-Migration and Anti-Invasion Effects of Curcumin via Suppression of Fascin Expression in Glioblastoma Cells
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Park KS, Yoon SY, Park SH, Hwang JH
- KMID: 2444791
- Brain Tumor Res Treat.
- 2019 Apr;7(1):16-24.
- doi: 10.14791/btrt.2019.7.e28
BACKGROUND: The natural compound curcumin was known to inhibit migration and invasion of glioblastoma (GBM) cells. Fascin, a kind of actin-binding proteins, is correlated with migration and invasion of GBM... -
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- Marked Increase of Circulating Double-Negative gammadelta T Cells in a Patient With Hydroa Vacciniforme-Like Lymphoma
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Shin SY, Park CH, Cho D, Kim HJ, Kim SH
- KMID: 2373540
- Ann Lab Med.
- 2016 May;36(3):268-270.
- doi: 10.3343/alm.2016.36.3.268
No abstract available. -
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- Role of STAT3 Phosphorylation in Ethanol-Mediated Proliferation of Breast Cancer Cells
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Narayanan , Nandabalan SK, Baddireddi LS
- KMID: 2308962
- J Breast Cancer.
- 2016 Jun;19(2):122-132.
- doi: 10.4048/jbc.2016.19.2.122
PURPOSE: In this study, we investigated the molecular mechanism involved in ethanol (EtOH)-mediated proliferation of breast cancer cells. METHODS: EtOH concentration was optimized by studying its effect on cell proliferation in... -
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- MiR-506 Promotes Natural Killer Cell Cytotoxicity against Human Hepatocellular Carcinoma Cells by Targeting STAT3
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Su Z, Ye X, Shang L
- KMID: 2428274
- Yonsei Med J.
- 2019 Jan;60(1):22-29.
- doi: 10.3349/ymj.2019.60.1.22
PURPOSE: It is well documented that natural killer (NK) cytotoxicity against hepatocellular carcinoma (HCC) cells is impaired in HCC, which might account for the failure of anti-tumor immune response. miRNAs... -
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- Janus Kinase 2 Inhibitor AG490 Inhibits the STAT3 Signaling Pathway by Suppressing Protein Translation of gp130
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Seo IA, Lee HK, Shin YK, Lee SH, Seo SY, Park JW, Park HT
- KMID: 2071662
- Korean J Physiol Pharmacol.
- 2009 Apr;13(2):131-138.
- doi: 10.4196/kjpp.2009.13.2.131
The binding of interleukin-6 (IL-6) cytokine family ligands to the gp130 receptor complex activates the Janus kinase (JAK)/ signal transducer and activator of transcription 3 (STAT3) signal transduction pathway,... -
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- T Cell-Specific Knockout of STAT3 Ameliorates Dextran Sulfate Sodium-Induced Colitis by Reducing the Inflammatory Response
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Kwon SH, Seo EB, Lee SH, Cho CH, Kim SJ, Kim SJ, Kim HR, Ye SK
- KMID: 2419775
- Immune Netw.
- 2018 Aug;18(4):e30.
- doi: 10.4110/in.2018.18.e30
Signal transducer and activator of transcription 3 (STAT3) has a crucial role in various autoimmune disorders including, inflammatory bowel disease (IBD). Our previous study demonstrated that STAT3 activation by IL-6... -
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- Effects of Oncostatin M on Invasion of Primary Trophoblasts under Normoxia and Hypoxia Conditions
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Wie JH, Ko HS, Choi SK, Park IY, Kim A, Kim HS, Shin JC
- KMID: 2428915
- Yonsei Med J.
- 2018 Sep;59(7):879-886.
- doi: 10.3349/ymj.2018.59.7.879
PURPOSE: To investigate the effect of oncostatin M (OSM) on protein expression levels and enzymatic activities of matrix metalloprotainase (MMP)-2 and MMP-9 in primary trophoblasts and the invasiveness thereof under... -
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- Methyl 9-Oxo-(10E,12E)-octadecadienoate Isolated from Fomes fomentarius Attenuates Lipopolysaccharide-Induced Inflammatory Response by Blocking Phosphorylation of STAT3 in Murine Macrophages
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Choe JH, Yi YJ, Lee MS, Seo DW, Yun BS, Lee SM
- KMID: 2312829
- Mycobiology.
- 2015 Sep;43(3):319-326.
- doi: 10.5941/MYCO.2015.43.3.319
Fomes fomentarius is a fungus of the Polyporaceae family and is used in traditional oriental therapies. Although the anti-inflammatory activities of this species have been previously reported, the identity of... -
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- Neuroprotective potential of imatinib in global ischemia-reperfusion-induced cerebral injury: possible role of Janus-activated kinase 2/signal transducer and activator of transcription 3 and connexin 43
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Wang J, Bai T, Wang N, Li H, Guo X
- KMID: 2466565
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):11-18.
- doi: 10.4196/kjpp.2020.24.1.11
The present study was aimed to explore the neuroprotective role of imatinib in global ischemia-reperfusion-induced cerebral injury along with possible mechanisms. Global ischemia was induced in mice by bilateral carotid... -
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