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Brain Factor-7® improves learning and memory deficits and attenuates ischemic brain damage by reduction of ROS generation in stroke in vivo and in vitro

Noh Y, Lee JW, Hong J, Kim SS, Ahn JH, Lee TK, Kim B, Won MH

Brain Factor-7® (BF-7), silk fibroin peptide, is known to be effective in improvement of memory and learning ability. In this study, the effects of BF-7 (10 mg/kg, p.o., pre-treatment for 7 days...
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MiR-212 Attenuates MPP+-Induced Neuronal Damage by Targeting KLF4 in SH-SY5Y Cells

Song Y, Liu Y, Chen X

PURPOSE: Parkinson's disease (PD) is a common age-dependent neurodegenerative disease. MiR-212 has been demonstrated to exert protective effects in several neurological disorders. The present study aimed to investigate the role...
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ATP13A2/PARK9 Deficiency Neither Cause Lysosomal Impairment Nor Alter alpha-Synuclein Metabolism in SH-SY5Y Cells

Bae EJ, Lee C, Lee HJ, Kim S, Lee SJ

Parkinson's disease is a multifactorial disorder with several genes linked to the familial types of the disease. ATP13A2 is one of those genes and encode for a transmembrane protein localized...
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Neuroprotective effects of resveratrol on 6-hydroxydopamine-induced damage of SH-SY5Y cell line

Chang GC, Kim HC, Wie MB

  • KMID: 1700783
  • Korean J Vet Res.
  • 2014 Mar;54(1):1-6.
Parkinson's disease is known to exhibit progressive degeneration of the dopaminergic neurons in the substantia nigra via inhibition of glutathione metabolism. It is well known that 6-Hydroxydopamine (6-OHDA) induces Parkinson's...
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Protective efficacy of an Ecklonia cava extract used to treat transient focal ischemia of the rat brain

Kim JH, Lee NS, Jeong YG, Lee JH, Kim EJ, Han SY

Phlorotannins (marine algal polyphenols) have been reported to exhibit beneficial biological activities, serving as both antioxidants and anti-inflammatory agents. Among marine algae, Ecklonia cava, a member of the Laminariaceae, is...
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Naringin Protects against Rotenone-induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells

Kim HJ, Song JY, Park HJ, Park HK, Yun DH, Chung JH

Rotenone, a mitochondrial complex I inhibitor, can induce the pathological features of Parkinson's disease (PD). In the present study, naringin, a grapefruit flavonoid, inhibited rotenone-induced cell death in human neuroblastoma...
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Enhancement of Arsenic Trioxide (As2O3)-Mediated Apoptosis Using Berberine in Human Neuroblastoma SH-SY5Y Cells

Kim DW, Ahan SH, Kim TY

OBJECTIVE: Arsenic trioxide (As2O3) has been used as an anticancer agent in traditional Chinese medicine for thousand years and berberine is an isoquinoline alkaloid present that has indicated significant antimicrobial...
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Effects of LED irradiation on the expression of apoptosis-related molecules in human SH-SY5Y neuroblastoma cells

Cho KS, Ryu SY, Choi HR

  • KMID: 2005233
  • J Korean Assoc Oral Maxillofac Surg.
  • 2007 Feb;33(1):1-10.
To verify the inhibitory or protective effects of light-emitting diode(LED) irradiation on apoptotic cell death induced by CoCl2, human SH-SY5Y cells were treated with CoCl2 and LED were used to...
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Stimulus-dependent Differential Regulation of JNK1 and JNK3 by JIP1 Scaffold Protein in Human Neuroblastoma, SH-SY5Y

Yu YM, Lee KW, Lee JK

  • KMID: 2224481
  • Korean J Anat.
  • 2006 Feb;39(1):47-53.
Activation of c-Jun N-terminal kinase (JNK) is associated with a wide range of disparate cellular responses to extracellular stimuli. In mammals, three JNK isoforms are known, and their differential regulation...
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Receptor Activation is Not the Main Rescue Mechanism of Morphine in Peroxynitrite-Induced Death of Human Neuroblastoma SH-SY5Y Cells

Son Y, Ahn JY, Choi YS, Song YK, Yoon JS, Kim TY, Cheong YP

BACKGROUND: In the present study, we examined the effect of morphine on NO- and peroxynitrite-induced cell death using a human neuroblastoma SH-SY5Y cell line which abundantly expresses micro, delta and...
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Effects of Morphine on Free Radical-induced Apoptosis of Human Neuroblastoma SH-SY5Y Cells

Ha JR, Cheong YP, Kim J, Choi DH, Lee CS, Son Y, Kim TY, Song YK, Yoon JS

BACKGROUND: The effect of opioids on nitric oxide (NO)- and peroxynitrite-induced neuronal cell death is largely unknown. In the present study, we examined the effect of morphine on NO-...
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Effects of dopamine and haloperidol on morphine-induced CREB and AP-1 DNA binding activities in differentiated SH-SY5Y human neuroblastoma cells

Kim SK, Kwon GY

  • KMID: 2071825
  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):671-676.
In the present study, we first examined whether the changes in the DNA binding activities of the transcription factors, cAMP response element binding protein (CREB) and activator protein-1 (AP-1) mediate the long-term effects...
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The c-myc expression on the opioid tolerance in human neuroblastoma SH-SY5Y cells

Kim SK, Park CK, Kwon GY, Suh SI

  • KMID: 2285187
  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):691-697.
The mechanisms underlying opiate tolerance and dependence are not fully understood. We used human neuroblastoma SH-SY5Y cells as a model system for studying effects of morphine tolerance and withdrawal on c-myc induction and...
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