- Memantine Improves Cognitive Function and Alters Hippocampal and Cortical Proteome in Triple Transgenic Mouse Model of Alzheimer's Disease
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Zhou X, Wang L, Xiao W, Su Z, Zheng C, Zhang Z, Wang Y, Xu B, Yang X, Hoi MP
- KMID: 2451074
- Exp Neurobiol.
- 2019 Jun;28(3):390-403.
- doi: 10.5607/en.2019.28.3.390
Memantine is a non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonist clinically approved for moderate-to-severe Alzheimer's disease (AD) to improve cognitive functions. There is no report about the proteomic alterations induced by memantine... -
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- Stage specific transcriptome analysis of liver tissue from a crossbred Korean Native Pig (KNP × Yorkshire)
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Kumar H, Srikanth K, Park W, Lee KT, Choi BH, Kim JM, Lim D, Park JE
- KMID: 2435748
- J Biomed Transl Res.
- 2018 Dec;19(4):116-124.
- doi: 10.12729/jbtr.2018.19.4.116
Korean Native Pig (KNP) has a uniform black coat color, excellent meat quality, white colored fat, solid fat structure and good marbling. However, its growth performance is low, while the... -
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- Molecular cloning and characterization of porcine ribosomal protein L21
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Sun WS, Chun JL, Kim DH, Ahn JS, Kim MK, Hwang IS, Kwon DJ, Hwang S, Lee JW
- KMID: 2398513
- J Vet Sci.
- 2017 Dec;18(4):531-540.
- doi: 10.4142/jvs.2017.18.4.531
Ribosomal protein L21 (RPL21) is a structural component of the 60S subunit of the eukaryotic ribosome. This protein has an important role in protein synthesis and the occurrence of hereditary... -
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- Modulating cellular balance of Rps3 mono-ubiquitination by both Hel2 E3 ligase and Ubp3 deubiquitinase regulates protein quality control
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Jung Y, Kim HD, Yang HW, Kim HJ, Jang CY, Kim J
- KMID: 2396795
- Exp Mol Med.
- 2017 Nov;49(11):e390.
- doi: 10.1038/emm.2017.128
When a ribosome complex is stalled during the translation elongation process in eukaryotes, the mono-ubiquitination of Rps3 has recently been shown to be critical to ribosome quality control. We have... -
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- Large-Scale in-House Cell-Based Assay for Evaluating the Serostatus in Patients with Neuromyelitis Optica Spectrum Disorder Based on New Diagnostic Criteria
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Kim Y, Kim G, Kong BS, Lee JE, Oh YM, Hyun JW, Kim SH, Joung A, Kim BJ, Choi K, Kim HJ
- KMID: 2376019
- J Clin Neurol.
- 2017 Apr;13(2):175-180.
- doi: 10.3988/jcn.2017.13.2.175
BACKGROUND AND PURPOSE: The detection of aquaporin 4-IgG (AQP4-IgG) is now a critical diagnostic criterion for neuromyelitis optica spectrum disorder (NMOSD). To evaluate the serostatus of NMOSD patients based on... -
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- Current insights into inherited bone marrow failure syndromes
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Chung NG, Kim M
- KMID: 2353160
- Korean J Pediatr.
- 2014 Aug;57(8):337-344.
Inherited bone marrow failure syndrome (IBMFS) encompasses a heterogeneous and complex group of genetic disorders characterized by physical malformations, insufficient blood cell production, and increased risk of malignancies. They often... -
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- Incidence of Erythromycin Resistance Genes, erm(B) and mef(A), in Streptococci Isolated from Dental Plaques of Koreans
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Kim YH, Lee SY
- KMID: 1431095
- Int J Oral Biol.
- 2013 Jun;38(2):61-65.
Erythromycin is a macrolide antibiotic and inhibits bacterial protein synthesis by stimulating the dissociation of the peptidyl-tRNA molecule from the ribosomes during elongation. The use of macrolides has increased dramatically... -
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- Solitary Fibrous Tumor of the Conjunctiva with Heretofore Undescribed Pathologic Findings
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Kim NR, Ro JY, Shin KH, Paik HJ, An JS, Ha SY
- KMID: 1443740
- Korean J Pathol.
- 2011 Jun;45(3):315-318.
- doi: 10.4132/KoreanJPathol.2011.45.3.315
A 37-year-old female presented with a conjunctival mass discovered 3 years prior. An excisional biopsy revealed a patternless proliferation of round and spindle-shaped cells with an eosinophilic fibrillary cytoplasm and... -
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- Recent Methodological Approaches to Human Microbiome
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Bae JW
- KMID: 1449857
- J Bacteriol Virol.
- 2011 Mar;41(1):1-7.
- doi: 10.4167/jbv.2011.41.1.1
Human body is one of the most complex and diverse microbial ecosystem in which various microbes are living together with their hosts. Starting with Louis Pasteur's postulation that human health... -
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- Rapamycin-Induced Abundance Changes in the Proteome of Budding Yeast
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Shin CS, Chang YJ, Lee HG, Huh WK
- KMID: 2166467
- Genomics Inform.
- 2009 Dec;7(4):203-207.
The target of rapamycin (TOR) signaling pathway conserved from yeast to human plays critical roles in regulation of eukaryotic cell growth. It has been shown that TOR pathway is involved... -
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- Aminoglycoside Resistance in Gram-negative Bacilli
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Park YJ
- KMID: 1469953
- Korean J Clin Microbiol.
- 2009 Jun;12(2):57-61.
- doi: 10.5145/KJCM.2009.12.2.57
Aminoglycosides are one of the clinically relevant antibiotics. They kill bacteria by binding to bacterial 30S subunit of ribosome. Resistance to aminoglycosides occurs by three different mechanisms: 1. Production of... -
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- Emergence of macrolide resistance and clinical use of macrolide antimicrobials in children
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Choi EH
- KMID: 2280307
- Korean J Pediatr.
- 2008 Oct;51(10):1031-1037.
- doi: 10.3345/kjp.2008.51.10.1031
Macrolide antimicrobial agents including erythromycin, roxithromycin, clarithromycin, and azithromycin are commonly used in the treatment of respiratory tract infections in children. Newer macrolides that have structural modifications of older drug... -
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- Dual Expression of Two Transgenes Introduced by Lentiviral Vectors
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Park SJ, Choi SJ, Park JY, Lee KH
- KMID: 1574120
- J Bacteriol Virol.
- 2005 Jun;35(2):157-164.
Lentiviruses can infect mitotic and non-dividing cells owing to the karyophilic properties of their pre-integrating complex, which allow its active import through the nucleopore. Thus lentiviral vectors derived from human... -
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- Development of Dual Reporter System of Mutant Dopamine 2 Receptor (D2R) and Sodium Iodide Symporter (NIS) Transgenes
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Hwang DW, Lee DS, Kang JH, Chang YS, Kim YH, Jeong JM, Chung JK, Lee MC
- KMID: 1990860
- Korean J Nucl Med.
- 2004 Aug;38(4):294-299.
PURPOSE: Both human NIS and mutant D2R transgenes are proposed as reporting system in transplanted cell tracking. Using hepatoma cell lines, we constructed a dual reporter system containing human sodium-iodide... -
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- Expression of Sodium/iodide Symporter Transgene in Neural Stem Cells
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Kim YH, Lee DS, Kang JH, Lee YJ, Chung JK, Lee MC
- KMID: 1590238
- Korean J Nucl Med.
- 2004 Feb;38(1):99-108.
PURPOSE: The ability to noninvasively track the migration of neural progenitor cells would have significant clinical and research implications. We generated stably transfected F3 human neural progenitor cells with human... -
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- In vitro Effect of Kalopanaxsaponin A on the Ultrastructure of Trichomonas vaginalis
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Kim DJ, Cho YJ, Chu JP
- KMID: 2285148
- Infect Chemother.
- 2003 Dec;35(6):446-453.
BACKGROUND: T. vaginalis is a pathogenic protozoa infecting genitourinary tract. Metronidazole is a drug of choice to treat T. vaginalis infection. However, because of appearance of metronidazole- resistant T. vaginalis,... -
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- Establishement of Antibody Selection by Ribosome Display
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Lee MS, Kwon MH, Kim KH, Park S, Shin HJ, Kim HI
- KMID: 1615313
- Immune Netw.
- 2003 Sep;3(3):219-226.
- doi: 10.4110/in.2003.3.3.219
BACKGROUND: Phage display is the most widely used technique among display methods to produce monoclonal antibody fragment with a specific binding activity. Having a large library for efficient antibody display/selection... -
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- In vitro Effect of Sophora flavescens on the Ultrastructure of Trichomonas vaginalis Donne
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Choi WG, Cho YJ, Chu JP
- KMID: 2082960
- Korean J Infect Dis.
- 2002 Aug;34(4):248-254.
BACKGROUND: Trichomonas vaginalis is a pathogenic protozoa infecting human genitourinary tract. Metronidazole is currently the drug of choice to treat T. vaginalis infection. However, because of the side effects and... -
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- A Study on Ciliogenesis of Tracheal Epithelium in Human Fetus
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Kwon SH, Lee SE, Nam KI, Ahn KY, Bae CS, Park SS
- KMID: 1559317
- Korean J Anat.
- 2002 Aug;35(4):343-354.
Ciliogenesis was investigated in the tracheal epithelium of human fetus at mid trimester of gestation (15~22 weeks), and the substructure of basal body was studied with serial, cross sections. The ciliogenic cells... -
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- Electron Microscopic Studies on the Effects of Retinoic Acid on Palatogenesis in Fetal Rats
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Kim WK, Woo BS, Nam YS, Paik DJ, Youn J, Bae SM, Chung HS
- KMID: 2376084
- Korean J Phys Anthropol.
- 2001 Sep;14(3):249-258.
Retinoic acid (RA) is widely used to treat the dermatologic disorders, such as acne and psoriasis, but its usage is limited because of teratogenic effects. Moreover, it is known that... -
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